Cell type dependent transcription regulation by chick homeodomain proteins.

Abstract:

:Five chick homeodomain proteins (CHOXs), CHOX-1.7, -1.1, -1.4, -4.2 and -2.6, had different transcription-regulating activities in a chick cultured cell line, LMH. In particular, CHOX-1.7 highly activated transcription when NP6 was used as the target site whereas CHOX-1.4 did not. This was mainly due to differences in the activation domains since both proteins bound to NP with almost the same affinities in vitro. In LMH cells, they competitively acted on target gene transcription. Moreover, the strength of the CHOX-1.4 activation domain depended on the cell type. These findings suggest that the effect on a target gene is determined by a combination of CHOXs and cell types.

journal_name

Mech Dev

authors

Sasaki H,Yamamoto M,Kuroiwa A

doi

10.1016/0925-4773(92)90012-9

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

25-36

issue

1-2

eissn

0925-4773

issn

1872-6356

pii

0925-4773(92)90012-9

journal_volume

37

pub_type

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