Expression of the novel basic-helix-loop-helix transcription factor cMespo in presomitic mesoderm of chicken embryos.

abstract：:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

journal_title：Mechanisms of development

authors： Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

更新日期：2000-08-01 00:00:00

abstract：:In many animals, germline progenitors are kept undifferentiated to give rise to germline stem cells (GSCs), enabling continuous production of gametes throughout animal life. In the Drosophila ovary, GSCs arise from a subset of primordial germ cells (PGCs) that stay undifferentiated even after gametogenesis has started...

journal_title：Mechanisms of development

authors： Matsuoka S,Hiromi Y,Asaoka M

更新日期：2013-04-01 00:00:00

abstract：:Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. In RA resistant RAC65 cells, RAR beta 2 induction is b...

journal_title：Mechanisms of development

authors： Shen S,van der Saag PT,Kruijer W

更新日期：1993-03-01 00:00:00

abstract：:The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from v...

journal_title：Mechanisms of development

authors： Blanchette M,Daneman R

更新日期：2015-11-01 00:00:00

abstract：:DCC (deleted in colon cancer), Neogenin and UNC-5 are all members of the immunoglobulin superfamily of transmembrane receptors which are believed to play a role in axon guidance by binding to their ligands, the Netrin/UNC-40 family of secreted molecules (Cell. Mol. Life Sci. 56 (1999) 62; Curr. Opin. Genet. Dev. 7 (19...

journal_title：Mechanisms of development

authors： Hjorth JT,Gad J,Cooper H,Key B

更新日期：2001-11-01 00:00:00

abstract：:Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in ca...

journal_title：Mechanisms of development

authors： Liu Y,Lin Z,Liu M,Liao H,Chen Y,Zhang X,Chan HC,Zhou B,Rao L,Sun H

更新日期：2020-09-01 00:00:00

abstract：:Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detec...

journal_title：Mechanisms of development

authors： Close R,Toro S,Martial JA,Muller M

更新日期：2002-10-01 00:00:00

abstract：:A hallmark of germline cells throughout the animal kingdom is their ability to execute meiosis. However, despite its prime importance, little is known about how germline progenitors acquire this ability. In Drosophila, the primordial germ cells (PGCs) are characterized by the inheritance of germ plasm, which contains ...

journal_title：Mechanisms of development

authors： Mukai M,Hayashi Y,Kitadate Y,Shigenobu S,Arita K,Kobayashi S

更新日期：2007-08-01 00:00:00

abstract：:Skeletal muscle regeneration requires processes different from developmental myogenesis. One important difference is a requirement of inflammatory reactions prior to regenerative myogenesis, by which injured muscle fibers must be eliminated to make new myotubes. In this study, we show that efficient elimination of inj...

journal_title：Mechanisms of development

authors： Nishimura D,Sakai H,Sato T,Sato F,Nishimura S,Toyama-Sorimachi N,Bartsch JW,Sehara-Fujisawa A

更新日期：2015-02-01 00:00:00

abstract：:During early vertebrate development, a series of neuromeres divides the central nervous system from the forebrain to the spinal cord. Here we examine in more detail the expression of Wnt-3, a member of the Wnt gene family of secreted proteins, in the developing diencephalon, in comparison to the expression of the home...

journal_title：Mechanisms of development

authors： Salinas PC,Nusse R

更新日期：1992-12-01 00:00:00

abstract：:BMP2, like its Drosophila homologue dpp, is an important signaling molecule for specification of cardiogenic mesoderm in vertebrates. Here, we analyzed the time-course of BMP2-requirement for early heart formation in whole chick embryos and in explants of antero-lateral plate mesoderm. Addition of Noggin to explants i...

journal_title：Mechanisms of development

authors： Schlange T,Andrée B,Arnold HH,Brand T

更新日期：2000-03-01 00:00:00

abstract：:Hsp47 is a heat-shock protein which interacts with newly synthesize procollagen chains in the endoplasmic reticulum (ER) of collagen-secreting cells and is thought to assist in procollagen triple helix assembly and subsequent transport to the cis-Golgi. This is supported by studies which have reported that genes encod...

journal_title：Mechanisms of development

authors： Lele Z,Krone PH

更新日期：1997-01-01 00:00:00

abstract：:Three homeobox genes, one from Drosophila melanogaster (Drosophila Hmx gene) and two from mouse (murine Hmx2 and Hmx3) were isolated and the full-length cDNAs and corresponding genomic structures were characterized. The striking homeodomain similarity encoded by these three genes to previously identified genes in sea ...

journal_title：Mechanisms of development

authors： Wang W,Lo P,Frasch M,Lufkin T

更新日期：2000-12-01 00:00:00

abstract：:The existence of a common endodermal progenitor cell to both pancreas and liver is suggested by anatomy of the development of pancreatic and liver buds in embryogenesis. Here we review the large body of evidence that pancreas to liver and liver to pancreas cell differentiation can also occur in adult life. The publish...

journal_title：Mechanisms of development

authors： Grompe M

更新日期：2003-01-01 00:00:00

abstract：:Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can aff...

journal_title：Mechanisms of development

authors： Renault AD,Starz-Gaiano M,Lehmann R

更新日期：2002-12-01 00:00:00

abstract：:Fetal liver is the major embryonic hematopoietic organ and is extrinsically colonized by circulating hematopoietic stem cells (HSCs). Integrin beta-1 expression on HSCs is crucial for colonization, suggesting that interaction of Integrin beta-1 with extra-cellular matrix (ECM) factors promotes HSC adherence to fetal l...

journal_title：Mechanisms of development

authors： Sugiyama D,Kulkeaw K,Mizuochi C

更新日期：2013-02-01 00:00:00

abstract：:The fork head domain-containing gene family (Fox) comprises over 20 members in mammals and is defined by a conserved 110 amino-acid motif containing a winged helix structure DNA-binding domain. The members of this gene family have been implicated as key regulators of embryogenesis, cell cycling, cell lineage restricti...

journal_title：Mechanisms of development

authors： Tribioli C,Robledo RF,Lufkin T

更新日期：2002-10-01 00:00:00

abstract：:All body pigment cells in vertebrates are derived from the neural crest. In fish the neural crest can generate up to six different types of pigment cells, as well as various non-pigmented derivatives. In mouse and zebrafish, extensive collections of pigmentation mutants have enabled dissection of many aspects of pigme...

journal_title：Mechanisms of development

authors： Kelsh RN,Inoue C,Momoi A,Kondoh H,Furutani-Seiki M,Ozato K,Wakamatsu Y

更新日期：2004-07-01 00:00:00

abstract：:Mammalian Krüppel-like transcription factors include 12 zinc finger proteins (KLF1-12) that are involved in regulation of cell proliferation and differentiation during morphogenesis and development (Trends Biochem. Sci., 24 (1999) 236). Structural considerations have segregated KLF6 and KLF7 into a separate sub-group,...

journal_title：Mechanisms of development

authors： Laub F,Aldabe R,Ramirez F,Friedman S

更新日期：2001-08-01 00:00:00

abstract：:The gene tprd, which contains three tetratricopeptide domains, has been recently localized in the Down syndrome (DS) chromosomal region 1. We have cloned a cDNA encoding part of the murine ortholog of tprd and used it to characterize the expression pattern of this gene during development and at the adult stage. At E8....

journal_title：Mechanisms of development

authors： Lopes C,Rachidi M,Gassanova S,Sinet PM,Delabar JM

更新日期：1999-06-01 00:00:00

abstract：:In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

journal_title：Mechanisms of development

authors： Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

更新日期：2001-07-01 00:00:00

abstract：:Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitor cells (OPCs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. However, for oligoden...

journal_title：Mechanisms of development

authors： Hashimoto R,Hori K,Owa T,Miyashita S,Dewa K,Masuyama N,Sakai K,Hayase Y,Seto Y,Inoue YU,Inoue T,Ichinohe N,Kawaguchi Y,Akiyama H,Koizumi S,Hoshino M

更新日期：2016-05-01 00:00:00

abstract：:Using in situ hybridization on whole-mounts and sections of mouse embryos we have visualized the pattern of expression for the Eph receptor ligand ephrin-A5. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral...

journal_title：Mechanisms of development

authors： Zarbalis K,Wurst W

更新日期：2000-05-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:DCoH, the dimerization cofactor of the HNF-1 homeodomain proteins (hepatocyte nuclear factor-1alpha and beta), is involved in gene expression by associating with these transcription factors. The protein also called PCD for pterin-4alpha-carbinolamine dehydratase is a bifunctional factor as it catalyzes also the regene...

journal_title：Mechanisms of development

authors： Pogge v Strandmann E,Senkel S,Ryffel GU

更新日期：2000-03-01 00:00:00

abstract：:Dystroglycan is a transmembrane receptor protein that provides a structural linkage between extracellular matrix components and cytoskeletal proteins. It was originally characterized as a member of dystrophin associated protein complex in muscle but, unlike other proteins of this complex, mutations in the dystroglycan...

journal_title：Mechanisms of development

authors： Lunardi A,Dente L

更新日期：2002-12-01 00:00:00

abstract：:Homeodomain transcription factor CnNK-2 seems to play a major role in foot formation in Hydra. Recently, we reported in vitro evidence indicating that CnNK-2 has autoregulatory features and regulates expression of the morphogenetic peptide pedibin. We proposed that CnNK-2 and pedibin synergistically orchestrate foot d...

journal_title：Mechanisms of development

authors： Siebert S,Thomsen S,Reimer MM,Bosch TC

更新日期：2005-09-01 00:00:00

abstract：:Characterizing endogenous protein expression, interaction and function, this study identifies in vivo interactions and competitive balance between N-cadherin and E-cadherin in developing avian (Gallus gallus) neural and neural crest cells. Numerous cadherin proteins, including neural cadherin (Ncad) and epithelial cad...

journal_title：Mechanisms of development

authors： Rogers CD,Sorrells LK,Bronner ME

更新日期：2018-08-01 00:00:00

abstract：:In the Drosophila embryo, a subset of muscles require expression and function of the RYK subfamily RTK gene derailed (drl) for correct attachment. We have isolated a second RYK homolog, doughnut (dnt), from Drosophila. The DNT protein exhibits 60% amino acid identity to DRL, and is structurally as similar to the mamma...

journal_title：Mechanisms of development

authors： Oates AC,Bonkovsky JL,Irvine DV,Kelly LE,Thomas JB,Wilks AF

更新日期：1998-11-01 00:00:00

abstract：:Vertebrates display striking left-right asymmetries in the placement of internal organs, which are concealed by a seemingly bilaterally symmetric body plan. The establishment of asymmetries about the left-right axis occurs early during embryo development and requires the concerted and sequential action of several epig...

journal_title：Mechanisms of development

authors： Raya A,Izpisua Belmonte JC

更新日期：2004-09-01 00:00:00