Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila.

abstract：:The runt gene plays an important role in the genetic hierarchy that generates the segmented body pattern during the early stages of Drosophila embryogenesis. We studied mRNA expression in mutant embryos in order to investigate the regulation of runt transcription during these stages. We used sensitive whole-mount in s...

journal_title：Mechanisms of development

authors： Klingler M,Gergen JP

更新日期：1993-09-01 00:00:00

abstract：:In Drosophila, the homeotic gene Distal-less (Dll) has a fundamental role in the establishment of the identity of ventral appendages such as the leg and antenna. This study reports the expression pattern of Dll in the genital disc, the requirement of Dll activity for the development of the terminalia and the activatio...

journal_title：Mechanisms of development

authors： Gorfinkiel N,Sánchez L,Guerrero I

更新日期：1999-08-01 00:00:00

abstract：:A-kinase anchoring proteins (AKAPs) are a heterogeneous family of scaffolding proteins that regulate the compartmentalization of signaling components, in particular that of the broad specificity kinase PKA. Here we describe the identification of a new member of this gene family, termed Xenopus gravin-like (Xgl), which...

journal_title：Mechanisms of development

authors： Klingbeil P,Frazzetto G,Bouwmeester T

更新日期：2001-02-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:Haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious male fertility problems, from oligospermia to complete azoospermia. CHD5 is a chromatin-remodeling nuclear protein expressed almost exclusively ...

journal_title：Mechanisms of development

authors： Zhuang T,Hess RA,Kolla V,Higashi M,Raabe TD,Brodeur GM

更新日期：2014-02-01 00:00:00

abstract：:We have recently identified a new G protein-coupled receptor, msr/apj, whose transcripts are detected in the endothelium of the primary blood vessels and the newly forming heart (Mech. Dev. 1999;84:199). Its expression during formation of the embryonic vasculature incited us to investigate whether expression of the re...

journal_title：Mechanisms of development

authors： Saint-Geniez M,Masri B,Malecaze F,Knibiehler B,Audigier Y

更新日期：2002-01-01 00:00:00

abstract：:The odd-skipped (odd) gene encodes a zinc finger protein that represses other segmentation genes in the early Drosophila embryo. Though odd is initially expressed in a striped pattern that reflects its function within the segmentation hierarchy, it is also expressed in a variety of patterns during later stages of embr...

journal_title：Mechanisms of development

authors： Ward EJ,Coulter DE

更新日期：2000-09-01 00:00:00

abstract：:The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' pho...

journal_title：Mechanisms of development

authors： Karandikar UC,Trott RL,Yin J,Bishop CP,Bidwai AP

更新日期：2004-03-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:We examined the roles of Notch signaling and fibroblast growth factors (FGFs) in the gliogenesis of mouse mesencephalic neural crest cells. The present study demonstrated that Notch activation or FGF treatment promotes the differentiation of glia expressing glial fibrillary acidic protein. Notch activation or FGF2 exp...

journal_title：Mechanisms of development

authors： Ijuin K,Nakanishi K,Ito K

更新日期：2008-05-01 00:00:00

abstract：:The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes...

journal_title：Mechanisms of development

authors： Gómez-Skarmeta JL,de la Calle-Mustienes E,Modolell J,Mayor R

更新日期：1999-01-01 00:00:00

abstract：:We describe the sequence and expression pattern of Sp5, a novel member of the vertebrate Sp1 transcription factor gene family which consists of at least five members. This gene family is characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the p...

journal_title：Mechanisms of development

authors： Treichel D,Becker MB,Gruss P

更新日期：2001-03-01 00:00:00

abstract：:Members of the cysteine-rich protein (CRP) define a subclass of LIM-only proteins implicated mainly in muscle differentiation. Until now, very little is known concerning the expression of CRP encoding genes during vertebrate development. We describe here the isolation of a trout (Oncorhynchus mykiss) gene encoding a c...

journal_title：Mechanisms of development

authors： Delalande JM,Rescan PY

更新日期：1998-08-01 00:00:00

abstract：:We have investigated in detail the expression patterns of two Gata genes, cGata2 and cGata3, during early chick development. In addition to confirming previously described expression of these two genes in developing brain, kidney and blood islands, this study reveals several important novel expression domains during v...

journal_title：Mechanisms of development

authors： Sheng G,Stern CD

更新日期：1999-09-01 00:00:00

abstract：:Homeobox genes regulate multiple aspects of mouse development including the axial patterning in the central nervous system. Some of the more divergent members of this gene family are expressed in the anterior region of the central nervous system where the Hox genes are not expressed. We previously reported the isolati...

journal_title：Mechanisms of development

authors： Lu S,Wise TL,Ruddle FH

更新日期：1994-08-01 00:00:00

abstract：:Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators. In RA resistant RAC65 cells, RAR beta 2 induction is b...

journal_title：Mechanisms of development

authors： Shen S,van der Saag PT,Kruijer W

更新日期：1993-03-01 00:00:00

abstract：:The normal embryogenesis of marine animals is typically confined to a species-specific range of temperatures. Within that temperature range development results in a consistent, or canalized, phenotype, whereas above and below the range abnormal phenotypes are produced. This study reveals a high temperature threshold, ...

journal_title：Mechanisms of development

authors： Irvine SQ,McNulty KB,Siler EM,Jacobson RE

更新日期：2019-06-01 00:00:00

abstract：:The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal and wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring about ME...

journal_title：Mechanisms of development

authors： Campbell K,Casanova J,Skaer H

更新日期：2010-07-01 00:00:00

abstract：:In the process of cloning murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1. Here we report its sequence, chromosomal localisation and embryonic expression pattern....

journal_title：Mechanisms of development

authors： Tissier-Seta JP,Mucchielli ML,Mark M,Mattei MG,Goridis C,Brunet JF

更新日期：1995-05-01 00:00:00

abstract：:We have cloned a chick homologue of Drosophila dachshund (dac), termed Dach1. Dach1 is the orthologue of mouse and human Dac/Dach (hereafter referred to as Dach1). We show that chick Dach1 is expressed in a variety of sites during embryonic development, including the eye and ear. Previous work has demonstrated the exi...

journal_title：Mechanisms of development

authors： Heanue TA,Davis RJ,Rowitch DH,Kispert A,McMahon AP,Mardon G,Tabin CJ

更新日期：2002-02-01 00:00:00

abstract：:Endoreduplication cycles that lead to an increase of DNA ploidy and cell size occur in distinct spatial and temporal patterns during Drosophila development. Only little is known about the regulation of these modified cell cycles. We have investigated fore- and hindgut development and we present evidence that the Droso...

journal_title：Mechanisms of development

authors： Fuss B,Meissner T,Bauer R,Lehmann C,Eckardt F,Hoch M

更新日期：2001-01-01 00:00:00

abstract：:Ppp6c, which encodes the catalytic subunit of phosphoprotein phosphatase 6 (PP6), is conserved among eukaryotes from yeast to humans. In mammalian cells, PP6 targets IκBε for degradation, activates DNA-dependent protein kinase to trigger DNA repair, and is reportedly required for normal mitosis. Recently, Ppp6c mutati...

journal_title：Mechanisms of development

authors： Ogoh H,Tanuma N,Matsui Y,Hayakawa N,Inagaki A,Sumiyoshi M,Momoi Y,Kishimoto A,Suzuki M,Sasaki N,Ohuchi T,Nomura M,Teruya Y,Yasuda K,Watanabe T,Shima H

更新日期：2016-02-01 00:00:00

abstract：:Terminal portions of the Drosophila body pattern are specified by an extracellular ligand generated at each end of the early syncytial embryo. This ligand triggers the localized transcription of two gap segmentation genes, tailles (tll) and huckebein (hkb) through a signal transduction cascade involving the receptor t...

journal_title：Mechanisms of development

authors： Casanova J,Llimargas M,Greenwood S,Struhl G

更新日期：1994-10-01 00:00:00

abstract：:We describe a zebrafish gene, Ziro3, which is highly homologous to Xenopus and mouse iroquois3. Ziro3 expression starts during gastrulation in the dorsal axial mesoderm that develops into the notochord. Later, the expression is limited to the chordo-neural hinge in the tailbud. Ziro3 expression also occurs in the cent...

journal_title：Mechanisms of development

authors： Tan JT,Korzh V,Gong Z

更新日期：1999-09-01 00:00:00

abstract：:Dystroglycan is a transmembrane receptor protein that provides a structural linkage between extracellular matrix components and cytoskeletal proteins. It was originally characterized as a member of dystrophin associated protein complex in muscle but, unlike other proteins of this complex, mutations in the dystroglycan...

journal_title：Mechanisms of development

authors： Lunardi A,Dente L

更新日期：2002-12-01 00:00:00

abstract：:The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta. On the other hand, hum...

journal_title：Mechanisms of development

authors： Debacker C,Catala M,Labastie MC

更新日期：1999-07-01 00:00:00

abstract：:Endothelial to mesenchymal transition (EMT) that occurs during cardiac outflow tract (OFT) development is critical for formation of the semilunar valves. Fibulin-1 (Fbln1) is an extracellular matrix protein that is present at several sites of EMT, including the OFT (i.e., E9.5-10.5). The aim of this study was to deter...

journal_title：Mechanisms of development

authors： Harikrishnan K,Cooley MA,Sugi Y,Barth JL,Rasmussen LM,Kern CB,Argraves KM,Argraves WS

更新日期：2015-05-01 00:00:00

abstract：:The cloning of a Pax6 orthologue from the sepiolid squid Euprymna scolopes and its developmental expression pattern are described. The data are consistent with the presence of a single gene encoding a protein with highly conserved DNA-binding paired and homeodomains. A detailed expression analysis by in situ hybridiza...

journal_title：Mechanisms of development

authors： Hartmann B,Lee PN,Kang YY,Tomarev S,de Couet HG,Callaerts P

更新日期：2003-02-01 00:00:00

abstract：:Cell-to-cell communication is absolutely essential for multicellular organisms. Both animals and plants use chemicals called hormones for intercellular signaling. However, multicellularity of plants and animals has evolved independently, which led to establishment of distinct strategies in order to cope with variation...

journal_title：Mechanisms of development

authors： Löfke C,Luschnig C,Kleine-Vehn J

更新日期：2013-01-01 00:00:00

abstract：:The induction of sensory organ placodes, in particular the lens placode, represents the paradigm for induction. We show that medaka Sox3 is expressed in the neuroectoderm and in the placodes of all sensory organs prior to placode formation and subsequently in placode-derived tissues. Ectopic Sox3 expression leads to e...

journal_title：Mechanisms of development

authors： Köster RW,Kühnlein RP,Wittbrodt J

更新日期：2000-07-01 00:00:00