Regional expression of the Wnt-3 gene in the developing mouse forebrain in relationship to diencephalic neuromeres.

abstract：:Members of the TGFbeta superfamily of signalling molecules play important roles in mesendoderm induction and dorsoventral patterning of the vertebrate embryo. We cloned three intracellular mediators of TGFbeta signalling, smad1, 2 and 5, from the zebrafish. The three smad genes are expressed ubiquitously at the onset ...

journal_title：Mechanisms of development

authors： Müller F,Blader P,Rastegar S,Fischer N,Knöchel W,Strähle U

更新日期：1999-10-01 00:00:00

abstract：:Mutations in the renin-angiotensin system (RAS) genes are associated with congenital anomalies of the kidney and urinary tract (CAKUT). As angiotensin (Ang) II, the principal effector peptide growth factor of the RAS, stimulates ureteric bud (UB) branching in whole intact embryonic (E) metanephroi, defects in UB morph...

journal_title：Mechanisms of development

authors： Song R,Preston G,Yosypiv IV

更新日期：2011-09-01 00:00:00

abstract：:The diencephalon is the caudal part of the developing forebrain that gives rise to the epithalamus, thalamus, hypothalamus and retina. The mature diencephalon is functionally and anatomically parceled into well-defined nuclei. In an effort to understand how this region of the brain develops we examined the expression ...

journal_title：Mechanisms of development

authors： Lim Y,Golden JA

更新日期：2002-07-01 00:00:00

abstract：:The idea has been put forward that molecules and mechanisms acting during development are re-used during regeneration in the adult, for example in response to traumatic injury in order to re-establish the functional integrity of neuronal circuits. Members of the Eph family of receptor tyrosine kinases and their 'ligan...

journal_title：Mechanisms of development

authors： Knöll B,Isenmann S,Kilic E,Walkenhorst J,Engel S,Wehinger J,Bähr M,Drescher U

更新日期：2001-08-01 00:00:00

abstract：:The Fused (Fu) serine-threonine kinase and the Suppressor of fused (Su(fu)) product are part of the Hedgehog (Hh) signaling pathway both in embryos and in imaginal discs. In wing imaginal discs, the Hh signal induces Cubitus interruptus (Ci) accumulation and activates patched (ptc) and decapentaplegic (dpp) expression...

journal_title：Mechanisms of development

authors： Alves G,Limbourg-Bouchon B,Tricoire H,Brissard-Zahraoui J,Lamour-Isnard C,Busson D

更新日期：1998-11-01 00:00:00

abstract：:Ppp6c, which encodes the catalytic subunit of phosphoprotein phosphatase 6 (PP6), is conserved among eukaryotes from yeast to humans. In mammalian cells, PP6 targets IκBε for degradation, activates DNA-dependent protein kinase to trigger DNA repair, and is reportedly required for normal mitosis. Recently, Ppp6c mutati...

journal_title：Mechanisms of development

authors： Ogoh H,Tanuma N,Matsui Y,Hayakawa N,Inagaki A,Sumiyoshi M,Momoi Y,Kishimoto A,Suzuki M,Sasaki N,Ohuchi T,Nomura M,Teruya Y,Yasuda K,Watanabe T,Shima H

更新日期：2016-02-01 00:00:00

abstract：:We have investigated the mechanisms by which the epithelial apicolateral junctional complex (AJC) is generated during trophectoderm differentiation in the mouse blastocyst using molecular, structural and functional analyses. The mature AJC comprises an apical tight junction (TJ), responsible for intercellular sealing ...

journal_title：Mechanisms of development

authors： Sheth B,Fontaine JJ,Ponza E,McCallum A,Page A,Citi S,Louvard D,Zahraoui A,Fleming TP

更新日期：2000-10-01 00:00:00

abstract：:In endothelial cells that form capillary-like structures in vitro a variety of genes is upregulated as we have demonstrated previously. In addition to well known genes, we also identified genes never described in endothelial cells before. Here, we report the further characterization of one selected gene called cystein...

journal_title：Mechanisms of development

authors： Glienke J,Sturz A,Menrad A,Thierauch KH

更新日期：2002-12-01 00:00:00

abstract：:The gene crumbs (crb) of Drosophila encodes a transmembrane protein with 30 EGF-like and four laminin A G-domain-like repeats in its extracellular domain. Loss-of-function mutations lead to severe disorganization and degeneration of ectodermally derived embryonic epithelia. In embryos homozygous for crb8F105, an amorp...

journal_title：Mechanisms of development

authors： Wodarz A,Grawe F,Knust E

更新日期：1993-12-01 00:00:00

abstract：:The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygotes with a Balb/cA and 129/Ola mixed background. Here, we show that no neural tube defects are observed with a Balb/cA background. We also found hypoplasia of the liver, thymus and spl...

journal_title：Mechanisms of development

authors： Motoyama J,Kitajima K,Kojima M,Kondo S,Takeuchi T

更新日期：1997-08-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implica...

journal_title：Mechanisms of development

authors： Baumgartner S,Noll M

更新日期：1990-12-01 00:00:00

abstract：:To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...

journal_title：Mechanisms of development

authors： Ohuchi H,Kimura S,Watamoto M,Itoh N

更新日期：2000-07-01 00:00:00

abstract：:Imitation Switch (ISWI) is a member of the SWI2/SNF2 superfamily of ATP-dependent chromatin remodelers, which regulate transcription and maintain chromatin structure by mobilizing nucleosomes using the energy of ATP. Four distinct ISWI complexes have been identified in Xenopus oocytes. The developmental role of Xenopu...

journal_title：Mechanisms of development

authors： Dirscherl SS,Henry JJ,Krebs JE

更新日期：2005-11-01 00:00:00

abstract：:In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

journal_title：Mechanisms of development

authors： Nakamura Y,Matsuno K

更新日期：2003-08-01 00:00:00

abstract：:Mll, Brg1 and Brm are vertebrate homologues of Drosophila trithorax group (trxG) genes. We isolated chicken Mll cDNA clones, and examined patterns of Mll, Brg1 and Brm expression in chick embryos. All three genes were expressed from embryonic stage 2 onwards. Mll transcripts were just detectable in all tissues by in s...

journal_title：Mechanisms of development

authors： Schofield J,Isaac A,Golovleva I,Crawley A,Goodwin G,Tickle C,Brickell P

更新日期：1999-01-01 00:00:00

abstract：:The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The primary function of gastrulation is the correct placement of precursor tissues for subsequent morphogenesis. There is now mounting evidence that the body plan is established through inductive interactions between germ layer...

journal_title：Mechanisms of development

authors： Tam PP,Behringer RR

更新日期：1997-11-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:In the sea urchin embryo, Nodal is the earliest known signal to play a role in the specification of the oral ectodermal territory. Nodal, a TGF-beta ligand, is first expressed in the presumptive oral ectoderm at approximately 7 H of development. Nodal overexpression produces a distinctive bell-shaped phenotype with ex...

journal_title：Mechanisms of development

authors： Agca C,Klein WH,Venuti JM

更新日期：2009-05-01 00:00:00

abstract：:We have cloned a chick homologue of Drosophila dachshund (dac), termed Dach1. Dach1 is the orthologue of mouse and human Dac/Dach (hereafter referred to as Dach1). We show that chick Dach1 is expressed in a variety of sites during embryonic development, including the eye and ear. Previous work has demonstrated the exi...

journal_title：Mechanisms of development

authors： Heanue TA,Davis RJ,Rowitch DH,Kispert A,McMahon AP,Mardon G,Tabin CJ

更新日期：2002-02-01 00:00:00

abstract：:Medaka is an ideal model system for developmental studies as it combines the advantages of powerful genetics and classical embryology. Due to the accessibility, transparency and fast development, embryogenesis and morphogenesis can be followed in vivo. Microscopic time-lapse imaging, however, requires the immobilizati...

journal_title：Mechanisms of development

authors： Rembold M,Wittbrodt J

更新日期：2004-07-01 00:00:00

abstract：:The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

journal_title：Mechanisms of development

authors： Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

更新日期：1996-09-01 00:00:00

abstract：:Compelling evidence from in vivo model systems within the past decade shows that the APP family of proteins is important for synaptic development and function in the central and peripheral nervous systems. The synaptic role promises to be complex and multifaceted for several reasons. The three family members have over...

journal_title：Mechanisms of development

authors： Caldwell JH,Klevanski M,Saar M,Müller UC

更新日期：2013-06-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:The growth and patterning of Drosophila wing and notum primordia depend on their subdivision into progressively smaller domains by secreted signals that emanate from localized sources termed organizers. While the mechanisms that organize the wing primordium have been studied extensively, those that organize the notum ...

journal_title：Mechanisms of development

authors： Del Signore SJ,Hayashi T,Hatini V

更新日期：2012-07-01 00:00:00

abstract：:The dual nature of pancreatic tissue permits both endocrine and exocrine functions. Enzymatic secretions by the exocrine pancreas help digestive processes while the pancreatic hormones regulate glucose homeostasis and energy metabolism. Pancreas organogenesis is defined by a conserved array of signaling pathways that ...

journal_title：Mechanisms of development

authors： Dumasia NP,Pethe PS

更新日期：2020-12-01 00:00:00

abstract：:Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

journal_title：Mechanisms of development

authors： Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

更新日期：2000-06-01 00:00:00

abstract：:The vascularization of the central nervous system occurs by angiogenic sprouting, a process in which different factors like vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1/2 must act in a coordinated fashion. We investigated how these factors participate in capillarization of the cerebellum, an area...

journal_title：Mechanisms of development

authors： Acker T,Beck H,Plate KH

更新日期：2001-10-01 00:00:00

abstract：:The formation of mesoderm is an important developmental process of vertebrate embryos, which can be broken down into several steps; mesoderm induction, patterning, morphogenesis and differentiation. Although mesoderm formation in Xenopus has been intensively studied, much remains to be learned about the molecular even...

journal_title：Mechanisms of development

authors： Chen JA,Voigt J,Gilchrist M,Papalopulu N,Amaya E

更新日期：2005-03-01 00:00:00