CRUMBS is involved in the control of apical protein targeting during Drosophila epithelial development.

abstract：:Six genes are vertebrate homologues of the homeobox-containing gene sine oculis, which plays an essential role in controlling Drosophila compound eye development. Here we report the identification and expression patterns of all three subfamilies of Xenopus Six genes. Two Six2 subfamily genes (Six1, Six2) showed very s...

journal_title：Mechanisms of development

authors： Ghanbari H,Seo HC,Fjose A,Brändli AW

更新日期：2001-03-01 00:00:00

abstract：:The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing a...

journal_title：Mechanisms of development

authors： Ogita J,Isogai E,Sudo H,Sakiyama S,Nakagawara A,Koseki H

更新日期：2001-12-01 00:00:00

abstract：:Craniofacial development is a highly conserved process that requires complex interactions between neural crest cells (NCCs) and pharyngeal tissues derived from all three germ layers. Signals emanating from the pharyngeal endoderm drive differentiation of NCCs into craniofacial cartilage, and disruption of this process...

journal_title：Mechanisms of development

authors： Dworkin S,Simkin J,Darido C,Partridge DD,Georgy SR,Caddy J,Wilanowski T,Lieschke GJ,Doggett K,Heath JK,Jane SM

更新日期：2014-08-01 00:00:00

abstract：:ZT3, isolated from a murine muscle cell cDNA library by a low-stringency hybridization, encodes a zinc finger domain containing factor with a transcript of 5.0 kb. A 3' 2.5 kb partial nucleotide sequence contains an ORF of 1.5 kb where 17 canonical C2H2 zinc finger domains organized in tandem were identified. It maps ...

journal_title：Mechanisms of development

authors： Polimeni M,Giorgi S,De Gregorio L,Dragani TA,Molinaro M,Cossu G,Bouché M

更新日期：1996-01-01 00:00:00

abstract：:We studied the expression of MUL, a gene encoding a novel member of the RING-B-Box-Coiled Coil family of zinc finger proteins that underlies the human inherited disorder, Mulibrey nanism. In early human and mouse embryogenesis MUL is expressed in dorsal root and trigeminal ganglia, liver and in epithelia of multiple t...

journal_title：Mechanisms of development

authors： Lehesjoki AE,Reed VA,Mark Gardiner R,Greene ND

更新日期：2001-10-01 00:00:00

abstract：:In Drosophila, the homeotic gene Distal-less (Dll) has a fundamental role in the establishment of the identity of ventral appendages such as the leg and antenna. This study reports the expression pattern of Dll in the genital disc, the requirement of Dll activity for the development of the terminalia and the activatio...

journal_title：Mechanisms of development

authors： Gorfinkiel N,Sánchez L,Guerrero I

更新日期：1999-08-01 00:00:00

abstract：:The zebrafish biklf gene encodes a novel Krüppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The ...

journal_title：Mechanisms of development

authors： Kawahara A,Dawid IB

更新日期：2000-10-01 00:00:00

abstract：:The diencephalon is the caudal part of the developing forebrain that gives rise to the epithalamus, thalamus, hypothalamus and retina. The mature diencephalon is functionally and anatomically parceled into well-defined nuclei. In an effort to understand how this region of the brain develops we examined the expression ...

journal_title：Mechanisms of development

authors： Lim Y,Golden JA

更新日期：2002-07-01 00:00:00

abstract：:The embryonic fins and the tip of adult fins of teleost fish are supported by rows of straight, unmineralized fibrils called actinotrichia. The proximal ends of the actinotrichia are bundled and the mineralized bones called lepidotrichia are made along them. Since malformation in actinotrichia causes wavy fin bones, t...

journal_title：Mechanisms of development

authors： Kuroda J,Iwane AH,Kondo S

更新日期：2018-10-01 00:00:00

abstract：:Branching morphogenesis is a developmental process characteristic of many organ systems. Specifically, during renal branching morphogenesis, its been postulated that the final number of nephrons formed is one key clinical factor in the development of hypertension in adulthood. As it has been established that BMPs regu...

journal_title：Mechanisms of development

authors： Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

更新日期：2009-05-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:Nuclear orphan receptors are DNA binding proteins that share the domain structure of the nuclear hormone receptor superfamily, although ligands are unknown. We have identified an orphan receptor in Xenopus laevis and named it xGCNF based on its high degree of sequence homology to the previously described murine germ c...

journal_title：Mechanisms of development

authors： Joos TO,David R,Dreyer C

更新日期：1996-11-01 00:00:00

abstract：:Basic helix-loop-helix (bHLH) proteins of the Achaete/Scute (Ac/Sc) family are required for neurogenesis in both Drosophila and vertebrates. These transcription factors are commonly referred to as 'proneural' factors, as they promote neural fate in many contexts. Although Ac/Sc proteins have been studied in Hydra, jel...

journal_title：Mechanisms of development

authors： Doonan R,Hatzold J,Raut S,Conradt B,Alfonso A

更新日期：2008-09-01 00:00:00

abstract：:Normal sexual differentiation in the genital organs is essential for the animal species that use sexual reproduction. Although it is known that doublesex (dsx) is required for the sexual development of the genitalia in various insect species, the direct target genes responsible for the sexual differentiation of the ge...

journal_title：Mechanisms of development

authors： Wagamitsu S,Takase D,Aoki F,Suzuki MG

更新日期：2017-02-01 00:00:00

abstract：:The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' pho...

journal_title：Mechanisms of development

authors： Karandikar UC,Trott RL,Yin J,Bishop CP,Bidwai AP

更新日期：2004-03-01 00:00:00

abstract：:DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

journal_title：Mechanisms of development

authors： MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

更新日期：2000-07-01 00:00:00

abstract：:During the development of the proventriculus (glandular stomach) of the chicken embryo, the endodermal epithelium invades into the surrounding mesenchyme and forms glands. The glandular epithelial cells produce pepsinogen, while the non-glandular (luminal) epithelial cells secrete mucus. Sonic hedgehog is expressed un...

journal_title：Mechanisms of development

authors： Fukuda K,Kameda T,Saitoh K,Iba H,Yasugi S

更新日期：2003-07-01 00:00:00

abstract：:An enhancer sequence found in the Protease Nexin-1 (PN-1) gene was shown to drive lacZ expression specifically at the met-/mesencephalic junction in transgenic mouse embryos. A functional study of this enhancer has been performed to better understand the mechanisms regulating isthmic gene expression. An octamer-bindin...

journal_title：Mechanisms of development

authors： Mihailescu D,Küry P,Monard D

更新日期：1999-06-01 00:00:00

abstract：:Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

journal_title：Mechanisms of development

authors： Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

更新日期：1997-05-01 00:00:00

abstract：:Syndecans are a family of heparan sulfate proteoglycans implicated in cell-cell and cell-matrix interactions. To investigate the roles of syndecans in early development, we identified three syndecan family members in Xenopus laevis: Xsyn-1, Xsyn-2, and Xsyn-3. Xsyn-1 and Xsyn-2 are maternal mRNAs localized to the anim...

journal_title：Mechanisms of development

authors： Teel AL,Yost HJ

更新日期：1996-10-01 00:00:00

abstract：:High expression of the B1 Sox genes, Sox2 and Sox3, is associated with the development of definitive neural primordia, the neural plates, in early stage embryos. However, in the caudal lateral epiblast (CLE) where axial stem cells reside, Sox2 and Sox3 are expressed at low levels, together with Brachyury. Because axia...

journal_title：Mechanisms of development

authors： Yoshida M,Uchikawa M,Rizzoti K,Lovell-Badge R,Takemoto T,Kondoh H

更新日期：2014-05-01 00:00:00

abstract：:Mastermind, which is a Notch signal component, is a nuclear protein and is thought to contribute to the transactivation of target genes. Previously we showed that XMam1, Xenopus Mastermind1, was essential in the transactivation of a Notch target gene, XESR-1, and was involved in primary neurogenesis. To examine the fu...

journal_title：Mechanisms of development

authors： Katada T,Ito M,Kojima Y,Miyatani S,Kinoshita T

更新日期：2006-11-01 00:00:00

abstract：:The homeotic gene abdominal-A (abd-A) is normally expressed in parasegments 7 to 13. We find that the initial distribution of the product is approximately uniform within this domain, but the subsequent elaboration of the expression pattern results in differences between, as well as within, parasegments. We have invest...

journal_title：Mechanisms of development

authors： Macías A,Pelaz S,Morata G

更新日期：1994-04-01 00:00:00

abstract：:The bHLH protein eHAND is a sensitive marker for cardiovascular precursors in the Xenopus embryo. The earliest site of expression is a broad domain within the lateral plate mesoderm of the tailbud embryo. This domain comprises precursors that contribute to the posterior cardinal veins in later stages. Surprisingly, ex...

journal_title：Mechanisms of development

authors： Sparrow DB,Kotecha S,Towers N,Mohun TJ

更新日期：1998-02-01 00:00:00

abstract：:Xenopus embryos in solutions containing suramin show a dose-dependent decrease in the formation of dorsoanterior structures. Continuous treatment with 1 mM suramin produces embryos without mesodermal derivatives but with mesenchymal cells. Brief immersions of 20 min were used to determine the most sensitive stages and...

journal_title：Mechanisms of development

authors： Cardellini P,Polo C,Coral S

更新日期：1994-01-01 00:00:00

abstract：:Transcription of the human interphotoreceptor retinoid binding protein (IRBP) gene is strictly tissue specific, being restricted to retinal photoreceptors and pinealocytes. We have previously demonstrated that a sequence named A element, in the IRBP promoter is essential for IRBP gene transcription in vivo. Here we de...

journal_title：Mechanisms of development

authors： Bobola N,Briata P,Ilengo C,Rosatto N,Craft C,Corte G,Ravazzolo R

更新日期：1999-04-01 00:00:00

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:XLPOU91, a POU-homeobox gene is expressed in a narrow window during early Xenopus development. We show that ectopic expression of XLPOU91 RNA causes severe posterior truncations in embryos without inhibiting the formation of Spemann's organizer. Ectopic XLPOU91 expression also inhibits mesoderm induction by fibroblast...

journal_title：Mechanisms of development

authors： Henig C,Elias S,Frank D

更新日期：1998-02-01 00:00:00

abstract：:Homeobox genes regulate multiple aspects of mouse development including the axial patterning in the central nervous system. Some of the more divergent members of this gene family are expressed in the anterior region of the central nervous system where the Hox genes are not expressed. We previously reported the isolati...

journal_title：Mechanisms of development

authors： Lu S,Wise TL,Ruddle FH

更新日期：1994-08-01 00:00:00

abstract：:Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...

journal_title：Mechanisms of development

authors： de Navascués J,Modolell J

更新日期：2010-09-01 00:00:00