Expression of MUL, a gene encoding a novel RBCC family ring-finger protein, in human and mouse embryogenesis.

abstract：:The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

journal_title：Mechanisms of development

authors： Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

更新日期：1996-09-01 00:00:00

abstract：:It is now well established that apoptosis is induced in response to mechanical strain. Indeed, increasing compressive forces induces apoptosis in confined spheroids of tumour cells, whereas releasing stress reduces apoptosis in spheroids cultivated in free suspension (Cheng et al., 2009). Apoptosis can also be induced...

journal_title：Mechanisms of development

authors： Ambrosini A,Gracia M,Proag A,Rayer M,Monier B,Suzanne M

更新日期：2017-04-01 00:00:00

abstract：:Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis. Sequence analysis reveals that these genes are unlike any other gene identified to date, but they share two near-identical sequence domains. The Msg1 and Mrg1 expression profiles during ea...

journal_title：Mechanisms of development

authors： Dunwoodie SL,Rodriguez TA,Beddington RS

更新日期：1998-03-01 00:00:00

abstract：:We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous system (CNS), from the e...

journal_title：Mechanisms of development

authors： Crémazy F,Berta P,Girard F

更新日期：2000-05-01 00:00:00

abstract：:Gastrulation in vertebrates is a highly dynamic process driven by convergent extension movements of internal mesodermal cells, under the regulatory activity of the Spemann-Mangold or gastrula organizer. In a large-scale screen for genes expressed in the organizer, we have isolated a novel gene, termed Xmc, an acronym ...

journal_title：Mechanisms of development

authors： Frazzetto G,Klingbeil P,Bouwmeester T

更新日期：2002-04-01 00:00:00

abstract：:The neural crest (NC) is one of the most fascinating structures during embryonic development. Unique to vertebrate embryos, these cells give rise to important components of the craniofacial skeleton, such as the jaws and skull, as well as melanocytes and ganglia of the peripheral nervous system. Worldwide, several gro...

journal_title：Mechanisms of development

authors： Pescador GS,Trentin AG,Garcez RC

更新日期：2018-10-01 00:00:00

abstract：:In mammals, the SWI/SNF complex is involved in chromatin remodelling in a wide range of cellular events for which regulatory factors require access to DNA. In the present study, we analyzed in early postimplantation mouse embryos the expression pattern of BRM (SNF2alpha) and BRG1 (SNF2beta), which are both ATPase subu...

journal_title：Mechanisms of development

authors： Dauvillier S,Ott MO,Renard JP,Legouy E

更新日期：2001-03-01 00:00:00

abstract：:We report the characterization of a zebrafish DnaJ-like protein, homologue to the human Hsp40 protein hdj1, that we named zf-Hsp40. We have studied its expression during fin regeneration and we show that zf-Hsp40 mRNA level is drastically increased in all ray segments beneath the regenerated part, or blastema, in resp...

journal_title：Mechanisms of development

authors： Tawk M,Joulie C,Vriz S

更新日期：2000-12-01 00:00:00

abstract：:We have identified a short segment of the mouse Pax-6 gene 5' flanking region that is necessary and sufficient for reporter construct expression in components of the eye derived from non-neural ectoderm. This transcriptional control element has a highly conserved nucleotide sequence over 341 bp and is located approxim...

journal_title：Mechanisms of development

authors： Williams SC,Altmann CR,Chow RL,Hemmati-Brivanlou A,Lang RA

更新日期：1998-05-01 00:00:00

abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

journal_title：Mechanisms of development

authors： Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

更新日期：2002-11-01 00:00:00

abstract：:Branching morphogenesis is a developmental process characteristic of many organ systems. Specifically, during renal branching morphogenesis, its been postulated that the final number of nephrons formed is one key clinical factor in the development of hypertension in adulthood. As it has been established that BMPs regu...

journal_title：Mechanisms of development

authors： Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

更新日期：2009-05-01 00:00:00

abstract：:The homeotic gene abdominal-A (abd-A) is normally expressed in parasegments 7 to 13. We find that the initial distribution of the product is approximately uniform within this domain, but the subsequent elaboration of the expression pattern results in differences between, as well as within, parasegments. We have invest...

journal_title：Mechanisms of development

authors： Macías A,Pelaz S,Morata G

更新日期：1994-04-01 00:00:00

abstract：:Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

journal_title：Mechanisms of development

authors： Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

更新日期：2018-04-01 00:00:00

abstract：:Transcription of the human interphotoreceptor retinoid binding protein (IRBP) gene is strictly tissue specific, being restricted to retinal photoreceptors and pinealocytes. We have previously demonstrated that a sequence named A element, in the IRBP promoter is essential for IRBP gene transcription in vivo. Here we de...

journal_title：Mechanisms of development

authors： Bobola N,Briata P,Ilengo C,Rosatto N,Craft C,Corte G,Ravazzolo R

更新日期：1999-04-01 00:00:00

abstract：:In the sea urchin embryo, Nodal is the earliest known signal to play a role in the specification of the oral ectodermal territory. Nodal, a TGF-beta ligand, is first expressed in the presumptive oral ectoderm at approximately 7 H of development. Nodal overexpression produces a distinctive bell-shaped phenotype with ex...

journal_title：Mechanisms of development

authors： Agca C,Klein WH,Venuti JM

更新日期：2009-05-01 00:00:00

abstract：:We describe the structural organization of a gene, termed XFDL 141/156, that is transiently activated during early Xenopus development. XFDL 141/156 is first transcribed at the midblastula transition (MBT) and during early gastrulation events. A roughly 200 nucleotide fragment immediately 5' to the transcription start...

journal_title：Mechanisms of development

authors： Bellefroid E,Bourguignon C,Bouwmeester T,Rausch O,Blumberg B,Pieler T

更新日期：1997-04-01 00:00:00

abstract：:The gene expression patterns of primordial germ cells (PGCs) and embryonic stem cells were analyzed by a modified serial analysis of gene expression. During the process, we cloned a novel gene, PGC7, which was preferentially expressed in PGCs. Immunohistochemical analysis revealed that PGC7 was specifically expressed ...

journal_title：Mechanisms of development

authors： Sato M,Kimura T,Kurokawa K,Fujita Y,Abe K,Masuhara M,Yasunaga T,Ryo A,Yamamoto M,Nakano T

更新日期：2002-04-01 00:00:00

abstract：:Xenopus embryos in solutions containing suramin show a dose-dependent decrease in the formation of dorsoanterior structures. Continuous treatment with 1 mM suramin produces embryos without mesodermal derivatives but with mesenchymal cells. Brief immersions of 20 min were used to determine the most sensitive stages and...

journal_title：Mechanisms of development

authors： Cardellini P,Polo C,Coral S

更新日期：1994-01-01 00:00:00

abstract：:Dickkopf-1 (dkk-1) is member of a novel family of secreted proteins and functions in head induction during Xenopus embryogenesis, acting as a potent inhibitor of Wnt signalling. Here we report: (1) the isolation of two additional murine members of the dkk family, dkk-2 and dkk-3; and (2) analysis of adult and embryoni...

journal_title：Mechanisms of development

authors： Monaghan AP,Kioschis P,Wu W,Zuniga A,Bock D,Poustka A,Delius H,Niehrs C

更新日期：1999-09-01 00:00:00

abstract：:Recent work identified an apoptotic program in gastrulation stage Xenopus embryos (Anderson, J.A., Lewellyn, A.L., Maller, J.L., 1997. Mol. Biol. Cell 8, 1195-1206; Stack, J.H., Newport, J.W., 1997. Development 124, 3185-3195). Here, we characterize in detail this maternal cell death program, which is set up at fertil...

journal_title：Mechanisms of development

authors： Hensey C,Gautier J

更新日期：1997-12-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:The leucine zipper transcription factor TSC-22 (TGF-beta1 Stimulated Clone-22) was first isolated from a mouse osteoblast cell line as an immediate-early target gene of TGF-beta1. However, work with other cell lines, as well as with a Drosophila homolog, bunched, suggests that it is an effector gene of various growth ...

journal_title：Mechanisms of development

authors： Dohrmann CE,Belaoussoff M,Raftery LA

更新日期：1999-06-01 00:00:00

abstract：:In the Drosophila embryo the nuclear localisation of Dorsal, a member of the Rel family, is regulated by an extracellular signal, which is transmitted to the interior of the egg cell by a cascade of proteins involving the novel protein Tube and the protein kinase Pelle. Here we analyse the activation mechanism of Tube...

journal_title：Mechanisms of development

authors： Grosshans J,Schnorrer F,Nüsslein-Volhard C

更新日期：1999-03-01 00:00:00

abstract：:Six genes are vertebrate homologues of the homeobox-containing gene sine oculis, which plays an essential role in controlling Drosophila compound eye development. Here we report the identification and expression patterns of all three subfamilies of Xenopus Six genes. Two Six2 subfamily genes (Six1, Six2) showed very s...

journal_title：Mechanisms of development

authors： Ghanbari H,Seo HC,Fjose A,Brändli AW

更新日期：2001-03-01 00:00:00

abstract：:The intercalation of mesenchymal cells into epithelia, through mesenchymal-to-epithelial transition (MET), underlies organogenesis, for example, in nephrogenesis, and tissue regeneration, during cell renewal and wound repair. Despite its importance, surprisingly little is known about the mechanisms that bring about ME...

journal_title：Mechanisms of development

authors： Campbell K,Casanova J,Skaer H

更新日期：2010-07-01 00:00:00

abstract：:The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from v...

journal_title：Mechanisms of development

authors： Blanchette M,Daneman R

更新日期：2015-11-01 00:00:00

abstract：:NK-2 class homeobox genes are candidate patterning and lineage regulators in diverse organisms. We report here the embryonic expression pattern of murine member, Nkx2-6. In keeping with its vertebrate relatives, Nkx2-6 was transcribed in ventrolateral embryonic structures. Expression was first detected at E8.0 in endo...

journal_title：Mechanisms of development

authors： Biben C,Hatzistavrou T,Harvey RP

更新日期：1998-04-01 00:00:00

abstract：:The POU domain is a approximately 140 amino acid domain shared by several mammalian transcriptional activators. We have isolated genomic and cDNA clones from three Drosophila POU domain genes, designated pdm-1, pdm-2, and Cf1a. All three genes encode a conserved POU-specific domain and a POU homeo domain but are other...

journal_title：Mechanisms of development

authors： Billin AN,Cockerill KA,Poole SJ

更新日期：1991-06-01 00:00:00

abstract：:We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats contai...

journal_title：Mechanisms of development

authors： Ponassi M,Jacques TS,Ciani L,ffrench Constant C

更新日期：1999-02-01 00:00:00

abstract：:The products of the trithorax gene are required to stably maintain homeotic gene expression patterns established during embryo-genesis by the action of the transiently expressed segmentation genes. We have determined the intron/exon structure of the trx gene and the large alternatively spliced trx RNAs, which are capa...

journal_title：Mechanisms of development

authors： Stassen MJ,Bailey D,Nelson S,Chinwalla V,Harte PJ

更新日期：1995-08-01 00:00:00