Zebrafish Hsp40 and Hsc70 genes are both induced during caudal fin regeneration.

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:The growth and patterning of Drosophila wing and notum primordia depend on their subdivision into progressively smaller domains by secreted signals that emanate from localized sources termed organizers. While the mechanisms that organize the wing primordium have been studied extensively, those that organize the notum ...

journal_title：Mechanisms of development

authors： Del Signore SJ,Hayashi T,Hatini V

更新日期：2012-07-01 00:00:00

abstract：:Skeletal muscle regeneration requires processes different from developmental myogenesis. One important difference is a requirement of inflammatory reactions prior to regenerative myogenesis, by which injured muscle fibers must be eliminated to make new myotubes. In this study, we show that efficient elimination of inj...

journal_title：Mechanisms of development

authors： Nishimura D,Sakai H,Sato T,Sato F,Nishimura S,Toyama-Sorimachi N,Bartsch JW,Sehara-Fujisawa A

更新日期：2015-02-01 00:00:00

abstract：:This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (mesonephric) duct, Mullerian (paramesonephric) duct, mesonephric tubules, and gonad...

journal_title：Mechanisms of development

authors： Plyler ZE,Birket SE,Schultz BD,Hong JS,Rowe SM,Petty CF,Crowley MR,Crossman DK,Schoeb TR,Sorscher EJ

更新日期：2019-02-01 00:00:00

abstract：:Avian neural crest cells migrate on precise pathways to their target areas where they form a wide variety of cellular derivatives, including neurons, glia, pigment cells and skeletal components. In one portion of their pathway, trunk neural crest cells navigate in the somitic mesoderm in a segmental fashion, invading ...

journal_title：Mechanisms of development

authors： Krull CE

更新日期：2001-07-01 00:00:00

abstract：:The transcription factor scleraxis (SCX) is expressed throughout tendon development and plays a key role in directing tendon wound healing. However, little is known regarding its role in fetal or young postnatal tendons, stages in development that are known for their enhanced regenerative capabilities. Here we used RN...

journal_title：Mechanisms of development

authors： Paterson YZ,Evans N,Kan S,Cribbs A,Henson FMD,Guest DJ

更新日期：2020-09-01 00:00:00

abstract：:Craniofacial development is a highly conserved process that requires complex interactions between neural crest cells (NCCs) and pharyngeal tissues derived from all three germ layers. Signals emanating from the pharyngeal endoderm drive differentiation of NCCs into craniofacial cartilage, and disruption of this process...

journal_title：Mechanisms of development

authors： Dworkin S,Simkin J,Darido C,Partridge DD,Georgy SR,Caddy J,Wilanowski T,Lieschke GJ,Doggett K,Heath JK,Jane SM

更新日期：2014-08-01 00:00:00

abstract：:There has been rapid progress recently in the identification of signalling pathways regulating tooth development. It has become apparent that signalling networks involved in Drosophila development and development of mammalian organs such as the limb are also used in tooth development. Teeth are epithelial appendages f...

journal_title：Mechanisms of development

authors： Thesleff I,Sharpe P

更新日期：1997-10-01 00:00:00

abstract：:Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can aff...

journal_title：Mechanisms of development

authors： Renault AD,Starz-Gaiano M,Lehmann R

更新日期：2002-12-01 00:00:00

abstract：:The dual nature of pancreatic tissue permits both endocrine and exocrine functions. Enzymatic secretions by the exocrine pancreas help digestive processes while the pancreatic hormones regulate glucose homeostasis and energy metabolism. Pancreas organogenesis is defined by a conserved array of signaling pathways that ...

journal_title：Mechanisms of development

authors： Dumasia NP,Pethe PS

更新日期：2020-12-01 00:00:00

abstract：:Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrinsic primary defect in the heart. Here, we used zebrafish, which lack lung tissue, to investigate the role of CFTR in ca...

journal_title：Mechanisms of development

authors： Liu Y,Lin Z,Liu M,Liao H,Chen Y,Zhang X,Chan HC,Zhou B,Rao L,Sun H

更新日期：2020-09-01 00:00:00

abstract：:In endothelial cells that form capillary-like structures in vitro a variety of genes is upregulated as we have demonstrated previously. In addition to well known genes, we also identified genes never described in endothelial cells before. Here, we report the further characterization of one selected gene called cystein...

journal_title：Mechanisms of development

authors： Glienke J,Sturz A,Menrad A,Thierauch KH

更新日期：2002-12-01 00:00:00

abstract：:During Drosophila eye development, cell differentiation is preceded by the formation of a morphogenetic furrow, which progresses across the epithelium from posterior to anterior. Cells within the morphogenetic furrow are apically constricted and shortened along their apical-basal axis. However, how these cell shape ch...

journal_title：Mechanisms of development

authors： Schlichting K,Dahmann C

更新日期：2008-08-01 00:00:00

abstract：:Mouse embryos lacking Gsc and Dkk1 function display severe deficiencies in craniofacial structures which are not found in either Dkk1 homozygous null or Gsc homozygous null mutant embryos. Loss of Gsc has a dosage-related effect on the severity of head truncation phenotype in Dkk1 heterozygous embryos. The synergistic...

journal_title：Mechanisms of development

authors： Lewis SL,Khoo PL,Andrea De Young R,Bildsoe H,Wakamiya M,Behringer RR,Mukhopadhyay M,Westphal H,Tam PP

更新日期：2007-02-01 00:00:00

abstract：:We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. La...

journal_title：Mechanisms of development

authors： Nataf V,Grapin-Botton A,Champeval D,Amemiya A,Yanagisawa M,Le Douarin NM

更新日期：1998-07-01 00:00:00

abstract：:A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implica...

journal_title：Mechanisms of development

authors： Baumgartner S,Noll M

更新日期：1990-12-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:We describe the identification and detailed expression pattern of a second Drosophila Sox gene, SoxNeuro (SoxN), highly related to mammalian group B Sox1, 2, 3 genes. SoxN is expressed in a highly dynamic pattern during embyogenesis, being associated with the development of the central nervous system (CNS), from the e...

journal_title：Mechanisms of development

authors： Crémazy F,Berta P,Girard F

更新日期：2000-05-01 00:00:00

abstract：:Male and female embryonic stem (ES) cell lines were derived from the area pellucidae of Stage X (EG&K) chicken embryos. These ES cell lines were grown in culture for extended periods of time and the majority of the cells retained a diploid karyotype. When reintroduced into Stage VI-X (EG&K) recipient embryos, the cES ...

journal_title：Mechanisms of development

authors： van de Lavoir MC,Mather-Love C,Leighton P,Diamond JH,Heyer BS,Roberts R,Zhu L,Winters-Digiacinto P,Kerchner A,Gessaro T,Swanberg S,Delany ME,Etches RJ

更新日期：2006-01-01 00:00:00

abstract：:Using in situ hybridization on whole-mounts and sections of mouse embryos we have visualized the pattern of expression for the Eph receptor ligand ephrin-A5. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral...

journal_title：Mechanisms of development

authors： Zarbalis K,Wurst W

更新日期：2000-05-01 00:00:00

abstract：:Following tissue damage the immune response, including inflammation, has been considered an inevitable condition to build the host defense against invading pathogens. The recruitment of innate immune leukocytes to injured tissue is observed in both vertebrates and invertebrates. However, it is still not conclusive whe...

journal_title：Mechanisms of development

authors： Katsuyama T,Paro R

更新日期：2013-02-01 00:00:00

abstract：:Mastermind, which is a Notch signal component, is a nuclear protein and is thought to contribute to the transactivation of target genes. Previously we showed that XMam1, Xenopus Mastermind1, was essential in the transactivation of a Notch target gene, XESR-1, and was involved in primary neurogenesis. To examine the fu...

journal_title：Mechanisms of development

authors： Katada T,Ito M,Kojima Y,Miyatani S,Kinoshita T

更新日期：2006-11-01 00:00:00

abstract：:Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dep...

journal_title：Mechanisms of development

authors： Minoura I,Nakamura H,Tashiro K,Shiokawa K

更新日期：1995-01-01 00:00:00

abstract：:A-kinase anchoring proteins (AKAPs) are a heterogeneous family of scaffolding proteins that regulate the compartmentalization of signaling components, in particular that of the broad specificity kinase PKA. Here we describe the identification of a new member of this gene family, termed Xenopus gravin-like (Xgl), which...

journal_title：Mechanisms of development

authors： Klingbeil P,Frazzetto G,Bouwmeester T

更新日期：2001-02-01 00:00:00

abstract：:The SRY-related, HMG box SoxB1 transcription factors are highly homologous, evolutionarily conserved proteins that are expressed in neuroepithelial cells throughout neural development. SoxB1 genes are down-regulated as cells exit the cell-cycle to differentiate and are considered functionally redundant in maintaining ...

journal_title：Mechanisms of development

authors： Rogers CD,Harafuji N,Archer T,Cunningham DD,Casey ES

更新日期：2009-01-01 00:00:00

abstract：:DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

journal_title：Mechanisms of development

authors： MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

更新日期：2000-07-01 00:00:00

abstract：:Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

journal_title：Mechanisms of development

authors： Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

更新日期：2000-06-01 00:00:00

abstract：:Tetrapod fore-and hindlimbs have evolved from the pectoral and pelvic fins of an ancient vertebrate ancestor. In this ancestor, the pectoral fin appears to have arisen following the rostral homeotic recapitulation of an existing pelvic appendage (Tabin and Laufer (1993), Nature 361, 692-693). Thus the basic appendage ...

journal_title：Mechanisms of development

authors： Gibson-Brown JJ,Agulnik SI,Chapman DL,Alexiou M,Garvey N,Silver LM,Papaioannou VE

更新日期：1996-05-01 00:00:00

abstract：:The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta. On the other hand, hum...

journal_title：Mechanisms of development

authors： Debacker C,Catala M,Labastie MC

更新日期：1999-07-01 00:00:00

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00