Isolation of a family of Drosophila POU domain genes expressed in early development.

abstract：:Members of the T-box (tbx) gene family encode developmentally regulated transcription factors, several of which are implicated in human hereditary diseases. We have cloned the paralogous genes tbx15 and tbx18 in zebrafish and have characterised their expression in detail. tbx15 is expressed in paraxial head mesenchyme...

journal_title：Mechanisms of development

authors： Begemann G,Gibert Y,Meyer A,Ingham PW

更新日期：2002-06-01 00:00:00

abstract：:The Drosophila fat facets and canoe genes regulate non-neural cell fate decisions during ommatidium formation. We have shown previously that the FAM (fat facets in mouse) de-ubiquitinating enzyme regulates the function of AF-6, (mammalian canoe homologue), in the MDCK epithelial cell line (Taya et al., 1998. The Ras t...

journal_title：Mechanisms of development

authors： Kanai-Azuma M,Mattick JS,Kaibuchi K,Wood SA

更新日期：2000-03-01 00:00:00

abstract：:We have made a null mutation in the mouse activin beta B gene by deleting the portion of the gene encoding the proteolytic cleavage site and the majority of the coding region for the mature processed protein. Mice homozygous for this mutation complete embryogenesis and are completely viable. Approximately 40% of the h...

journal_title：Mechanisms of development

authors： Schrewe H,Gendron-Maguire M,Harbison ML,Gridley T

更新日期：1994-07-01 00:00:00

abstract：:Using a Drosophila cell-free system, we have analyzed the regulation of alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts. Splicing of MHC 3' end transcripts results in exclusion of adult-specific alternative exon 18, as is observed in embryonic and larval muscle in vivo. Mutations that st...

journal_title：Mechanisms of development

authors： Hodges D,Bernstein SI

更新日期：1992-05-01 00:00:00

abstract：:Nemo-like kinases define a novel family of serine/threonine kinases that are involved in integrating multiple signaling pathways. They are conserved regulators of Wnt/Wingless pathways, which may coordinate Wnt with TGFbeta-mediated signaling. Drosophila nemo was identified through its involvement in epithelial planar...

journal_title：Mechanisms of development

authors： Mirkovic I,Charish K,Gorski SM,McKnight K,Verheyen EM

更新日期：2002-11-01 00:00:00

abstract：:The full length sequence of the Xenopus integrin alpha 5 subunit is reported. Analysis of cloned cDNA fragments reveals that alternative polyadenylation of alpha 5 mRNA occurs in the embryo. Furthermore, a variant form of the alpha 5 mRNA is expressed which encodes an integrin alpha 5 subunit with a truncated cytoplas...

journal_title：Mechanisms of development

authors： Joos TO,Whittaker CA,Meng F,DeSimone DW,Gnau V,Hausen P

更新日期：1995-04-01 00:00:00

abstract：:Maleless (mle) is essential in Drosophila melanogaster males both in somatic cells and in germ cells. In somatic cells mle is necessary for X-chromosome dosage compensation. The role of mle in the germline is unknown. We have analyzed the expression pattern and localization of MLE, the other MSLs and acetylated isofor...

journal_title：Mechanisms of development

authors： Rastelli L,Kuroda MI

更新日期：1998-02-01 00:00:00

abstract：:In chick embryos, naso-temporal polarity of the retina becomes established before Hamburger-Hamilton stage 10. To examine the plasticity of the early eye anlage, double-temporal eyes were made using stage 10-11 (E1.5) chick embryos and stage 8-9 quail embryos. In vivo and in vitro experiments revealed that these doubl...

journal_title：Mechanisms of development

authors： Mueller BK,Dütting D,Haase A,Feucht A,Macchi P

更新日期：1998-06-01 00:00:00

abstract：:Members of the cysteine-rich protein (CRP) define a subclass of LIM-only proteins implicated mainly in muscle differentiation. Until now, very little is known concerning the expression of CRP encoding genes during vertebrate development. We describe here the isolation of a trout (Oncorhynchus mykiss) gene encoding a c...

journal_title：Mechanisms of development

authors： Delalande JM,Rescan PY

更新日期：1998-08-01 00:00:00

abstract：:Msg1 and Mrg1 are founding members of a gene family which exhibit distinct patterns of gene expression during mouse embryogenesis. Sequence analysis reveals that these genes are unlike any other gene identified to date, but they share two near-identical sequence domains. The Msg1 and Mrg1 expression profiles during ea...

journal_title：Mechanisms of development

authors： Dunwoodie SL,Rodriguez TA,Beddington RS

更新日期：1998-03-01 00:00:00

abstract：:Blood vessel maturation, which is characterized by the investment of vascular smooth muscle cells (vSMCs) around developing blood vessels, begins when vessels remodel into a hierarchy of proximal arteries and proximal veins that branch into smaller distal capillaries. The ultimate result of maturation is formation of ...

journal_title：Mechanisms of development

authors： Padget RL,Mohite SS,Hoog TG,Justis BS,Green BE,Udan RS

更新日期：2019-04-01 00:00:00

abstract：:Preimplantation embryo development is an important and unique period and is strictly controlled. This period includes a series of critical events that are regulated by multiple signal-transduction pathways, all of which are crucial in the establishment of a viable pregnancy. The p38 mitogen-activated protein kinase (M...

journal_title：Mechanisms of development

authors： Sozen B,Ozturk S,Yaba A,Demir N

更新日期：2015-11-01 00:00:00

abstract：:The expression pattern of K(+) currents is the principal regulator of electrical activity during development of the nervous and muscular system. We report here a study showing the expression pattern of HERG K(+) currents-encoding (erg) genes in various nervous and muscular tissues at different stages of quail embryo d...

journal_title：Mechanisms of development

authors： Crociani O,Cherubini A,Piccini E,Polvani S,Costa L,Fontana L,Hofmann G,Rosati B,Wanke E,Olivotto M,Arcangeli A

更新日期：2000-07-01 00:00:00

abstract：:X-chromosome inactivation (XCI) is an epigenetic mechanism that occurs in the eutherian embryo development to equalize the dosage of X-linked genes between males and females. This event is regulated by various factors, and the genes located in the X-chromosome inactivation center (XIC), which is known to be an evoluti...

journal_title：Mechanisms of development

authors： Hwang JY,Oh JN,Park CH,Lee DK,Lee CK

更新日期：2015-11-01 00:00:00

abstract：:We have investigated in detail the expression patterns of two Gata genes, cGata2 and cGata3, during early chick development. In addition to confirming previously described expression of these two genes in developing brain, kidney and blood islands, this study reveals several important novel expression domains during v...

journal_title：Mechanisms of development

authors： Sheng G,Stern CD

更新日期：1999-09-01 00:00:00

abstract：:The zebrafish biklf gene encodes a novel Krüppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The ...

journal_title：Mechanisms of development

authors： Kawahara A,Dawid IB

更新日期：2000-10-01 00:00:00

abstract：:The localization of RNAs at the vegetal cortex in Xenopus oocytes is a complex process, involving at least two different pathways. The early, or messenger transport organizer (METRO), pathway, localizes RNAs such as Xlsirts, Xcat2 and Xwnt11 during stages 1 and 2 of oogenesis, while the late pathway localizes RNAs suc...

journal_title：Mechanisms of development

authors： Kloc M,Etkin LD

更新日期：1998-04-01 00:00:00

abstract：:Hsp47 is a heat-shock protein which interacts with newly synthesize procollagen chains in the endoplasmic reticulum (ER) of collagen-secreting cells and is thought to assist in procollagen triple helix assembly and subsequent transport to the cis-Golgi. This is supported by studies which have reported that genes encod...

journal_title：Mechanisms of development

authors： Lele Z,Krone PH

更新日期：1997-01-01 00:00:00

abstract：:We describe the cloning, expression pattern and functional overexpression analysis of Xotx5b, a new member of the Otx gene family in Xenopus laevis. Early expression of Xotx5b resembles that of Xotx2, being detected in the organizer region at early gastrula stage, and, shortly after, also in anterior neuroectoderm. Du...

journal_title：Mechanisms of development

authors： Vignali R,Colombetti S,Lupo G,Zhang W,Stachel S,Harland RM,Barsacchi G

更新日期：2000-08-01 00:00:00

abstract：:Characterizing endogenous protein expression, interaction and function, this study identifies in vivo interactions and competitive balance between N-cadherin and E-cadherin in developing avian (Gallus gallus) neural and neural crest cells. Numerous cadherin proteins, including neural cadherin (Ncad) and epithelial cad...

journal_title：Mechanisms of development

authors： Rogers CD,Sorrells LK,Bronner ME

更新日期：2018-08-01 00:00:00

abstract：:The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' pho...

journal_title：Mechanisms of development

authors： Karandikar UC,Trott RL,Yin J,Bishop CP,Bidwai AP

更新日期：2004-03-01 00:00:00

abstract：:Male and female embryonic stem (ES) cell lines were derived from the area pellucidae of Stage X (EG&K) chicken embryos. These ES cell lines were grown in culture for extended periods of time and the majority of the cells retained a diploid karyotype. When reintroduced into Stage VI-X (EG&K) recipient embryos, the cES ...

journal_title：Mechanisms of development

authors： van de Lavoir MC,Mather-Love C,Leighton P,Diamond JH,Heyer BS,Roberts R,Zhu L,Winters-Digiacinto P,Kerchner A,Gessaro T,Swanberg S,Delany ME,Etches RJ

更新日期：2006-01-01 00:00:00

abstract：:In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

journal_title：Mechanisms of development

authors： Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

更新日期：2001-07-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:The gene tprd, which contains three tetratricopeptide domains, has been recently localized in the Down syndrome (DS) chromosomal region 1. We have cloned a cDNA encoding part of the murine ortholog of tprd and used it to characterize the expression pattern of this gene during development and at the adult stage. At E8....

journal_title：Mechanisms of development

authors： Lopes C,Rachidi M,Gassanova S,Sinet PM,Delabar JM

更新日期：1999-06-01 00:00:00

abstract：:ActR-I is a type I serine/threonine kinase receptor which has been shown to bind activin and bone morphogenetic proteins (BMPs). To study the function of ActR-I, we have generated novel monoclonal antibodies that specifically recognize the extracellular domain of mouse ActR-I. We examined the level of ActR-I protein d...

journal_title：Mechanisms of development

authors： Yoshikawa SI,Aota S,Shirayoshi Y,Okazaki K

更新日期：2000-03-01 00:00:00

abstract：:Homeobox genes regulate multiple aspects of mouse development including the axial patterning in the central nervous system. Some of the more divergent members of this gene family are expressed in the anterior region of the central nervous system where the Hox genes are not expressed. We previously reported the isolati...

journal_title：Mechanisms of development

authors： Lu S,Wise TL,Ruddle FH

更新日期：1994-08-01 00:00:00

abstract：:Ovotestis development in B6-XY(POS) mice provides a rare opportunity to study the interaction of the testis- and ovary-determining pathways in the same tissue. We studied expression of several markers of mouse fetal testis (SRY, SOX9) or ovary (FOXL2, Rspo1) development in B6-XY(POS) ovotestes by immunofluorescence, u...

journal_title：Mechanisms of development

authors： Wilhelm D,Washburn LL,Truong V,Fellous M,Eicher EM,Koopman P

更新日期：2009-05-01 00:00:00

abstract：:Homeodomain transcription factor CnNK-2 seems to play a major role in foot formation in Hydra. Recently, we reported in vitro evidence indicating that CnNK-2 has autoregulatory features and regulates expression of the morphogenetic peptide pedibin. We proposed that CnNK-2 and pedibin synergistically orchestrate foot d...

journal_title：Mechanisms of development

authors： Siebert S,Thomsen S,Reimer MM,Bosch TC

更新日期：2005-09-01 00:00:00

abstract：:Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

journal_title：Mechanisms of development

authors： Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

更新日期：1993-04-01 00:00:00