erg gene(s) expression during development of the nervous and muscular system of quail embryos.

abstract：:Wnt-4 signaling plays a critical role in kidney development and is associated with the epithelial conversion of the metanephric mesenchyme. Furthermore, secreted Frizzled-related proteins (sFRPs) that can bind Wnts are normally expressed in the developing metanephros, and function in other systems as modulators of Wnt...

journal_title：Mechanisms of development

authors： Yoshino K,Rubin JS,Higinbotham KG,Uren A,Anest V,Plisov SY,Perantoni AO

更新日期：2001-04-01 00:00:00

abstract：:Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined P...

journal_title：Mechanisms of development

authors： Chang H,Matzuk MM

更新日期：2001-06-01 00:00:00

abstract：:We have generated a null allele of the mouse Msx1 homeobox gene by insertion of an nlacZ reporter gene into its homeobox. The sensitivity of beta-galactosidase detection permitted us to reveal novel aspects of Msx1 gene expression in heterozygous embryos, in particular in ectoderm and mesoderm during gastrulation, and...

journal_title：Mechanisms of development

authors： Houzelstein D,Cohen A,Buckingham ME,Robert B

更新日期：1997-07-01 00:00:00

abstract：:The homeotic gene abdominal-A (abd-A) is normally expressed in parasegments 7 to 13. We find that the initial distribution of the product is approximately uniform within this domain, but the subsequent elaboration of the expression pattern results in differences between, as well as within, parasegments. We have invest...

journal_title：Mechanisms of development

authors： Macías A,Pelaz S,Morata G

更新日期：1994-04-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:Cell fate specification during inner ear development is dependent upon regional gene expression within the otic vesicle. One of the earliest cell fate determination steps in this system is the specification of neural precursors, and regulators of this process include the Atonal-related basic helix-loop-helix genes, Ng...

journal_title：Mechanisms of development

authors： Friedman RA,Makmura L,Biesiada E,Wang X,Keithley EM

更新日期：2005-05-01 00:00:00

abstract：:The putative vertebrate morphogen retinoic acid (RA) has been shown to induce expression of many mammalian homeobox genes in cell lines, suggesting expression of this gene family in developing vertebrate embryos may be controlled in part by RA. Using the teratocarcinoma cell line F9 as a model system, we have studied ...

journal_title：Mechanisms of development

authors： Langston AW,Gudas LJ

更新日期：1992-09-01 00:00:00

abstract：:The effects of signal perturbation on expression domains of molecular markers for the mesoderm and ectoderm have been analysed across the dorso-ventral axis in zebrafish embryos. Injection of RNA encoding bone morphogenetic protein-4 (BMP-4) ventralised the embryo, expanding the intermediate mesoderm and non-neural ec...

journal_title：Mechanisms of development

authors： Neave B,Holder N,Patient R

更新日期：1997-03-01 00:00:00

abstract：:SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. S...

journal_title：Mechanisms of development

authors： Charbonnier F,Chanoine C,Cifuentes-Diaz C,Gallien CL,Rieger F,Alliel PM,Périn JP

更新日期：2000-02-01 00:00:00

abstract：:We report the expression pattern of a murine homolog of the Xenopus laevis T-box gene Eomesodermin. mEomes expression is first detected in the extra-embryonic ectoderm prior to gastrulation, and persists there until head-fold stages. In the embryo proper, mEomes is expressed throughout the early primitive streak, nasc...

journal_title：Mechanisms of development

authors： Ciruna BG,Rossant J

更新日期：1999-03-01 00:00:00

abstract：:Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted ex...

journal_title：Mechanisms of development

authors： Liu L,Chong SW,Balasubramaniyan NV,Korzh V,Ge R

更新日期：2002-08-01 00:00:00

abstract：:Using in situ hybridization on whole-mounts and sections of mouse embryos we have visualized the pattern of expression for the Eph receptor ligand ephrin-A5. Non neuronal expression domains include the ectoderm of the branchial arches, the ectoderm and mesenchyme surrounding the dorsal root ganglia, the intervertebral...

journal_title：Mechanisms of development

authors： Zarbalis K,Wurst W

更新日期：2000-05-01 00:00:00

abstract：:The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that...

journal_title：Mechanisms of development

authors： Summerbell D,Halai C,Rigby PW

更新日期：2002-09-01 00:00:00

abstract：:The zebrafish biklf gene encodes a novel Krüppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The ...

journal_title：Mechanisms of development

authors： Kawahara A,Dawid IB

更新日期：2000-10-01 00:00:00

abstract：:The synchronous development of a sibling group of Rhynchosciara larvae enables us to follow the relationship between the local transcription and extrareplication of C3 and C8 DNA puffs. Although DNA amplification at these two loci takes place during the last cycle of DNA duplication in salivary gland chromosomes, a di...

journal_title：Mechanisms of development

authors： Santelli RV,Machado-Santelli GM,Pueyo MT,Navarro-Cattapan LD,Lara FJ

更新日期：1991-12-01 00:00:00

abstract：:Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC...

journal_title：Mechanisms of development

authors： Smithers L,Haddon C,Jiang YJ,Lewis J

更新日期：2000-01-01 00:00:00

abstract：:The Polycomb group genes in Drosophila are involved in the stable and inheritable repression of gene expression. The Polycomb group proteins probably operate as multimeric complexes that bind to chromatin. To investigate molecular mechanisms of stable repression of gene activity in vertebrates we have begun to study X...

journal_title：Mechanisms of development

authors： Reijnen MJ,Hamer KM,den Blaauwen JL,Lambrechts C,Schoneveld I,van Driel R,Otte AP

更新日期：1995-09-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the pancreatic transcription factor Pdx1 (XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic cells produced? (2) is the requirement for...

journal_title：Mechanisms of development

authors： Li WC,Horb ME,Tosh D,Slack JM

更新日期：2005-06-01 00:00:00

abstract：:Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

journal_title：Mechanisms of development

authors： Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

更新日期：1993-04-01 00:00:00

abstract：:Lipids, in addition to being structural components of cell membranes, can act as signaling molecules. Bioactive lipids, such as sphingosine 1-phosphate (S1P) and lysophosphatidic acid (LPA), may act intracellularly as second messengers or be secreted and act as intercellular signaling molecules. Such molecules can aff...

journal_title：Mechanisms of development

authors： Renault AD,Starz-Gaiano M,Lehmann R

更新日期：2002-12-01 00:00:00

abstract：:The Dan gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in vertebrates. Xenopus DAN, as with Cerberus and Gremlin, was demonstrated to block bone morphogenetic protein (BMP) signaling by binding BMPs, and to be capable of inducing a...

journal_title：Mechanisms of development

authors： Ogita J,Isogai E,Sudo H,Sakiyama S,Nakagawara A,Koseki H

更新日期：2001-12-01 00:00:00

abstract：:In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror...

journal_title：Mechanisms of development

authors： Matsuda T,Nomi M,Ikeya M,Kani S,Oishi I,Terashima T,Takada S,Minami Y

更新日期：2001-07-01 00:00:00

abstract：:Proteoglycans are cell surface and extracellular matrix molecules to which long, unbranched glycosaminoglycan side chains are attached. Heparan sulphate, a type of glycosaminoglycan chain, has been proposed as a co-factor necessary for signalling by a range of growth factors. Here we provide evidence that loss of 2-O-...

journal_title：Mechanisms of development

authors： McLaughlin D,Karlsson F,Tian N,Pratt T,Bullock SL,Wilson VA,Price DJ,Mason JO

更新日期：2003-12-01 00:00:00

abstract：:This study utilizes morphological and mechanistic endpoints to characterize the onset of bilateral atresia of the vas deferens in a recently derived cystic fibrosis (CF) rat model. Embryonic reproductive structures, including Wolffian (mesonephric) duct, Mullerian (paramesonephric) duct, mesonephric tubules, and gonad...

journal_title：Mechanisms of development

authors： Plyler ZE,Birket SE,Schultz BD,Hong JS,Rowe SM,Petty CF,Crowley MR,Crossman DK,Schoeb TR,Sorscher EJ

更新日期：2019-02-01 00:00:00

abstract：:Six/sine oculis (Six/so) class genes, with representatives in vertebrates and invertebrates, include members with key developmental roles in the anterior part of the central nervous system (CNS) and eye. Having characterized the role of the first planarian gene of the Six/so family in eye development, we attempted to ...

journal_title：Mechanisms of development

authors： Pineda D,Saló E

更新日期：2002-12-01 00:00:00

abstract：:The gene tprd, which contains three tetratricopeptide domains, has been recently localized in the Down syndrome (DS) chromosomal region 1. We have cloned a cDNA encoding part of the murine ortholog of tprd and used it to characterize the expression pattern of this gene during development and at the adult stage. At E8....

journal_title：Mechanisms of development

authors： Lopes C,Rachidi M,Gassanova S,Sinet PM,Delabar JM

更新日期：1999-06-01 00:00:00

abstract：:The Mix/Bix family of Pax-like homeodomain transcription factors is expressed early in vertebrate development and play important roles in endoderm and mesoderm formation. Like other Pax-related homeodomain proteins, the Mix/Bix family binds DNA as monomers or dimers and dimerization is mediated by the homeodomain. Whi...

journal_title：Mechanisms of development

authors： Doherty JR,Zhu H,Kuliyev E,Mead PE

更新日期：2006-01-01 00:00:00

abstract：:We have identified ramshackle (ram) as a dominant suppressor of hedgehog loss-of-function in the developing Drosophila eye. We have characterized the gene and it encodes a double bromodomain protein with eight WD40 repeats. The Ram protein is localized predominantly to polytene chromosome interbands and is required fo...

journal_title：Mechanisms of development

authors： D'Costa A,Reifegerste R,Sierra S,Moses K

更新日期：2006-08-01 00:00:00

abstract：:Mitochondrial large rRNA (mtlrRNA) and small rRNA (mtsrRNA) have been identified as components of germinal granules in Drosophila. We have previously reported that mtlrRNA is present on the germinal granules in Xenopus embryos. Here we report that mtsrRNA is also a common component of the germinal granules. Extra-mito...

journal_title：Mechanisms of development

authors： Kashikawa M,Amikura R,Kobayashi S

更新日期：2001-03-01 00:00:00