Planarian Gtsix3, a member of the Six/so gene family, is expressed in brain branches but not in eye cells.

abstract：:The availability of the draft sequence of the chicken genome will undoubtedly propel an already important vertebrate research model, the domestic chicken, to a new level. This review describes aspects of chicken natural history and cross-disciplinary biological value. The diversity of extant genetic variants available...

journal_title：Mechanisms of development

authors： Delany ME

更新日期：2004-09-01 00:00:00

abstract：:Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC...

journal_title：Mechanisms of development

authors： Smithers L,Haddon C,Jiang YJ,Lewis J

更新日期：2000-01-01 00:00:00

abstract：:The selective sensitivity of cells to programmed cell death (PCD) depends on the positive and negative death-inducing signals that converge into the apoptotic pathway. In Drosophila, the midline glial (MG) cells undergo selective death during development. Here, we show that the long isoform of the RNA-binding protein ...

journal_title：Mechanisms of development

authors： Reuveny A,Elhanany H,Volk T

更新日期：2009-01-01 00:00:00

abstract：:The development of skeletal muscle in vertebrate embryos is controlled by a transcriptional cascade involving the four myogenic regulatory factors. In the somites of the mouse embryo the order of expression is thought to be Myf5, Myogenin, Mrf4 and MyoD. We have re-examined the expression pattern of Mrf4 and show that...

journal_title：Mechanisms of development

authors： Summerbell D,Halai C,Rigby PW

更新日期：2002-09-01 00:00:00

abstract：:ActR-I is a type I serine/threonine kinase receptor which has been shown to bind activin and bone morphogenetic proteins (BMPs). To study the function of ActR-I, we have generated novel monoclonal antibodies that specifically recognize the extracellular domain of mouse ActR-I. We examined the level of ActR-I protein d...

journal_title：Mechanisms of development

authors： Yoshikawa SI,Aota S,Shirayoshi Y,Okazaki K

更新日期：2000-03-01 00:00:00

abstract：:The central nervous system (CNS) is vascularized by a dense capillary network that is critical to deliver oxygen and nutrients, and remove carbon dioxide and waste products, from the neural tissue. These blood vessels contain a series of properties, termed the blood-brain barrier (BBB), which distinguishes them from v...

journal_title：Mechanisms of development

authors： Blanchette M,Daneman R

更新日期：2015-11-01 00:00:00

abstract：:Mitochondrial large rRNA (mtlrRNA) and small rRNA (mtsrRNA) have been identified as components of germinal granules in Drosophila. We have previously reported that mtlrRNA is present on the germinal granules in Xenopus embryos. Here we report that mtsrRNA is also a common component of the germinal granules. Extra-mito...

journal_title：Mechanisms of development

authors： Kashikawa M,Amikura R,Kobayashi S

更新日期：2001-03-01 00:00:00

abstract：:The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred strain background but become highly methylated at postimplantation stages in offspring of a cross with a BALB/c female. In the reciprocal cross the transgene remains demethylated suggesting that imprinted BALB/c methylation modifiers ...

journal_title：Mechanisms of development

authors： Pickard B,Dean W,Engemann S,Bergmann K,Fuermann M,Jung M,Reis A,Allen N,Reik W,Walter J

更新日期：2001-05-01 00:00:00

abstract：:We have sequenced and defined the expression during rat embryogenesis of the protocadherin fat, the murine homologue of a Drosophila tumour suppressor gene. As previously described for human fat, the sequence encodes a large protocadherin with 34 cadherin repeats, five epidermal growth factor (EGF)-like repeats contai...

journal_title：Mechanisms of development

authors： Ponassi M,Jacques TS,Ciani L,ffrench Constant C

更新日期：1999-02-01 00:00:00

abstract：:We analyse the role of the empty spiracles (ems) gene in embryonic brain and ventral nerve cord development. ems is differentially expressed in the neurectoderm of the anterior head versus the trunk region of early embryos. A distal enhancer region drives expression in the deutocerebral brain anlage and a proximal enh...

journal_title：Mechanisms of development

authors： Hartmann B,Hirth F,Walldorf U,Reichert H

更新日期：2000-02-01 00:00:00

abstract：:We have isolated a Xenopus homologue of the zinc finger/homeodomain-containing transcriptional repressor Smad-interacting protein-1 (SIP1) from mouse. XSIP1 is activated at the early gastrula stage and transcription occurs throughout embryogenesis. At the beginning of gastrulation, XSIP1 is strongly expressed in prosp...

journal_title：Mechanisms of development

authors： van Grunsven LA,Papin C,Avalosse B,Opdecamp K,Huylebroeck D,Smith JC,Bellefroid EJ

更新日期：2000-06-01 00:00:00

abstract：:The chick dermis is known to control the formation of feathers and interfeathery skin in a hexagonal pattern. The evidence that the segregation of two types of fibroblasts involves Delta/Notch signalling is based on three facts. Rings of C-Delta-1-expressing fibroblasts precede and delimit the forming feather primordi...

journal_title：Mechanisms of development

authors： Viallet JP,Prin F,Olivera-Martinez I,Hirsinger E,Pourquié O,Dhouailly D

更新日期：1998-03-01 00:00:00

abstract：:Mammalian and Drosophila homologues of Baf57 have been previously isolated as being a subunit of SWI/SNF-like chromatin remodeling complexes. Here, we report the cloning and developmental expression of Xenopus Baf57. We isolated XBaf57 by using an expression cloning approach to identify novel modulators of Xenopus Sma...

journal_title：Mechanisms of development

authors： Domingos PM,Obukhanych TV,Altmann CR,Hemmati-Brivanlou A

更新日期：2002-08-01 00:00:00

abstract：:Male and female embryonic stem (ES) cell lines were derived from the area pellucidae of Stage X (EG&K) chicken embryos. These ES cell lines were grown in culture for extended periods of time and the majority of the cells retained a diploid karyotype. When reintroduced into Stage VI-X (EG&K) recipient embryos, the cES ...

journal_title：Mechanisms of development

authors： van de Lavoir MC,Mather-Love C,Leighton P,Diamond JH,Heyer BS,Roberts R,Zhu L,Winters-Digiacinto P,Kerchner A,Gessaro T,Swanberg S,Delany ME,Etches RJ

更新日期：2006-01-01 00:00:00

abstract：:Commissureless (Comm) is a novel transmembrane molecule necessary both for commissural axons to cross the midline of the Drosophila central nervous system and normal synaptogenesis. Comm is able to reduce cell surface levels of Roundabout (Robo), a receptor for the midline repellent Slit, on commissural axons and unkn...

journal_title：Mechanisms of development

authors： Georgiou M,Tear G

更新日期：2003-09-01 00:00:00

abstract：:The Drosophila pointed gene encodes two ETS transcriptional activators, pointedP1 and pointedP2, sharing a common C-terminal ETS domain. In the embryonic central nervous system pointedP2 is required for midline glial cell differentiation, whereas, in the eye, pointedP2 is essential for photoreceptor cell differentiati...

journal_title：Mechanisms of development

authors： Albagli O,Klaes A,Ferreira E,Leprince D,Klämbt C

更新日期：1996-09-01 00:00:00

abstract：:We have characterised a short (30 base pair) element from the Xenopus Wnt-5a promoter which is nearly identical to one located in the human Wnt-5a promoter, and has the same position relative to the transcription start site. When placed in front of a LacZ gene, this element can reproduce the same expression pattern ob...

journal_title：Mechanisms of development

authors： Morgan R,Hooiveld MH,In der Reiden P,Durston AJ

更新日期：1999-07-01 00:00:00

abstract：:We have isolated and characterized two complete cDNA clones, Zfz8a and Zfz8b, which encode zebrafish Frizzled (Fz) homologues. The predicted protein sequences, spanning 579 and 576 amino acid residues for ZFz8a and ZFz8b, respectively, were highly homologous (78%) to each other and contained an extracellular cysteine-...

journal_title：Mechanisms of development

authors： Kim SH,Park HC,Yeo SY,Hong SK,Choi JW,Kim CH,Weinstein BM,Huh TL

更新日期：1998-11-01 00:00:00

abstract：:Proteoglycans are cell surface and extracellular matrix molecules to which long, unbranched glycosaminoglycan side chains are attached. Heparan sulphate, a type of glycosaminoglycan chain, has been proposed as a co-factor necessary for signalling by a range of growth factors. Here we provide evidence that loss of 2-O-...

journal_title：Mechanisms of development

authors： McLaughlin D,Karlsson F,Tian N,Pratt T,Bullock SL,Wilson VA,Price DJ,Mason JO

更新日期：2003-12-01 00:00:00

abstract：:Haploinsufficiency for the HMG-box transcription factor SOX2 results in abnormalities of the human ventral forebrain and its derivative structures. These defects include anophthalmia (absence of eye), microphthalmia (small eye) and hypothalamic hamartoma (HH), an overgrowth of the ventral hypothalamus. To determine ho...

journal_title：Mechanisms of development

authors： Langer L,Taranova O,Sulik K,Pevny L

更新日期：2012-03-01 00:00:00

abstract：:We describe the expression of three Runt-related RUNX genes (previously termed AML, Cbfa, or Pebp2alpha) Runx1 and Runx3 during the development of teeth and other craniofacial tissues and compare them to Runx2 expression reported earlier. All three genes were expressed in mesenchymal condensates. Runx1 was expressed i...

journal_title：Mechanisms of development

authors： Yamashiro T,Aberg T,Levanon D,Groner Y,Thesleff I

更新日期：2002-12-01 00:00:00

abstract：:Branching morphogenesis is a developmental process characteristic of many organ systems. Specifically, during renal branching morphogenesis, its been postulated that the final number of nephrons formed is one key clinical factor in the development of hypertension in adulthood. As it has been established that BMPs regu...

journal_title：Mechanisms of development

authors： Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

更新日期：2009-05-01 00:00:00

abstract：:Fetal liver is the major embryonic hematopoietic organ and is extrinsically colonized by circulating hematopoietic stem cells (HSCs). Integrin beta-1 expression on HSCs is crucial for colonization, suggesting that interaction of Integrin beta-1 with extra-cellular matrix (ECM) factors promotes HSC adherence to fetal l...

journal_title：Mechanisms of development

authors： Sugiyama D,Kulkeaw K,Mizuochi C

更新日期：2013-02-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:The sex determining gene, Sry, determines the sex of the organism by initiating development of a testis rather than an ovary from the cells of the bipotential gonad. In the 10 years since the discovery of Sry, new genes and cellular pathways that operate in the establishment of the gonadal primordium and the initiatio...

journal_title：Mechanisms of development

authors： Capel B

更新日期：2000-03-15 00:00:00

abstract：:X-chromosome inactivation (XCI) is an epigenetic mechanism that occurs in the eutherian embryo development to equalize the dosage of X-linked genes between males and females. This event is regulated by various factors, and the genes located in the X-chromosome inactivation center (XIC), which is known to be an evoluti...

journal_title：Mechanisms of development

authors： Hwang JY,Oh JN,Park CH,Lee DK,Lee CK

更新日期：2015-11-01 00:00:00

abstract：:Preimplantation embryo development is an important and unique period and is strictly controlled. This period includes a series of critical events that are regulated by multiple signal-transduction pathways, all of which are crucial in the establishment of a viable pregnancy. The p38 mitogen-activated protein kinase (M...

journal_title：Mechanisms of development

authors： Sozen B,Ozturk S,Yaba A,Demir N

更新日期：2015-11-01 00:00:00

abstract：:DCC (deleted in colon cancer), Neogenin and UNC-5 are all members of the immunoglobulin superfamily of transmembrane receptors which are believed to play a role in axon guidance by binding to their ligands, the Netrin/UNC-40 family of secreted molecules (Cell. Mol. Life Sci. 56 (1999) 62; Curr. Opin. Genet. Dev. 7 (19...

journal_title：Mechanisms of development

authors： Hjorth JT,Gad J,Cooper H,Key B

更新日期：2001-11-01 00:00:00

abstract：:Exogenously applied retinoic acid given at the early stages of gastrulation causes abnormal development of the caudal midbrain and anterior hindbrain in vertebrate embryos. We describe the limits of the brain regions that are affected using neuroanatomical criteria in the zebrafish embryo. Analysis of the reticulospin...

journal_title：Mechanisms of development

authors： Hill J,Clarke JD,Vargesson N,Jowett T,Holder N

更新日期：1995-03-01 00:00:00

abstract：:Development of oligodendrocytes, myelin-forming glia in the central nervous system (CNS), proceeds on a protracted schedule. Specification of oligodendrocyte progenitor cells (OPCs) begins early in development, whereas their terminal differentiation occurs at late embryonic and postnatal periods. However, for oligoden...

journal_title：Mechanisms of development

authors： Hashimoto R,Hori K,Owa T,Miyashita S,Dewa K,Masuyama N,Sakai K,Hayase Y,Seto Y,Inoue YU,Inoue T,Ichinohe N,Kawaguchi Y,Akiyama H,Koizumi S,Hoshino M

更新日期：2016-05-01 00:00:00