Transcription regulation and alternative splicing of an early zygotic gene encoding two structurally distinct zinc finger proteins in Xenopus laevis.

abstract：:The development of multi-cellular organisms is regulated by the ordered definition of gene expression programmes that govern cell proliferation and differentiation. Although differential gene activity is mainly controlled by transcription factors, it is also dependent upon the underlying chromatin structure, which can...

journal_title：Mechanisms of development

authors： Czvitkovich S,Sauer S,Peters AH,Deiner E,Wolf A,Laible G,Opravil S,Beug H,Jenuwein T

更新日期：2001-09-01 00:00:00

abstract：:The phylogenetic location of hemichordates is unique because they seem to fill an evolutionary gap between echinoderms and chordates. We report here characterization of Pf-otx, a hemichordate ortholog of otx, with its embryonic and larval expression pattern. Pf-otx is initially expressed in the vegetal plate of the bl...

journal_title：Mechanisms of development

authors： Harada Y,Okai N,Taguchi S,Tagawa K,Humphreys T,Satoh N

更新日期：2000-03-01 00:00:00

abstract：:During early vertebrate development, a series of neuromeres divides the central nervous system from the forebrain to the spinal cord. Here we examine in more detail the expression of Wnt-3, a member of the Wnt gene family of secreted proteins, in the developing diencephalon, in comparison to the expression of the home...

journal_title：Mechanisms of development

authors： Salinas PC,Nusse R

更新日期：1992-12-01 00:00:00

abstract：:The Extramacrochaetae (emc) gene encodes a transcription factor with an HLH domain without the basic region involved in interaction with DNA present in other proteins that have this domain. EMC forms heterodimers with bHLH proteins preventing their binding to DNA, acting as a negative regulator. The function of emc is...

journal_title：Mechanisms of development

authors： Baonza A,García-Bellido A

更新日期：1999-02-01 00:00:00

abstract：:Craniofacial development is a highly conserved process that requires complex interactions between neural crest cells (NCCs) and pharyngeal tissues derived from all three germ layers. Signals emanating from the pharyngeal endoderm drive differentiation of NCCs into craniofacial cartilage, and disruption of this process...

journal_title：Mechanisms of development

authors： Dworkin S,Simkin J,Darido C,Partridge DD,Georgy SR,Caddy J,Wilanowski T,Lieschke GJ,Doggett K,Heath JK,Jane SM

更新日期：2014-08-01 00:00:00

abstract：:The odd-skipped (odd) gene encodes a zinc finger protein that represses other segmentation genes in the early Drosophila embryo. Though odd is initially expressed in a striped pattern that reflects its function within the segmentation hierarchy, it is also expressed in a variety of patterns during later stages of embr...

journal_title：Mechanisms of development

authors： Ward EJ,Coulter DE

更新日期：2000-09-01 00:00:00

abstract：:Haploid spermatids undergo extensive cellular, molecular and morphological changes to form spermatozoa during spermiogenesis. Abnormalities in these steps can lead to serious male fertility problems, from oligospermia to complete azoospermia. CHD5 is a chromatin-remodeling nuclear protein expressed almost exclusively ...

journal_title：Mechanisms of development

authors： Zhuang T,Hess RA,Kolla V,Higashi M,Raabe TD,Brodeur GM

更新日期：2014-02-01 00:00:00

abstract：:Maleless (mle) is essential in Drosophila melanogaster males both in somatic cells and in germ cells. In somatic cells mle is necessary for X-chromosome dosage compensation. The role of mle in the germline is unknown. We have analyzed the expression pattern and localization of MLE, the other MSLs and acetylated isofor...

journal_title：Mechanisms of development

authors： Rastelli L,Kuroda MI

更新日期：1998-02-01 00:00:00

abstract：:Active repression of gene expression mediated by unliganded nuclear receptors plays crucial roles in early development of vertebrates. N-CoR (nuclear receptor co-repressor) is the first identified co-repressor that can repress retinoic acid (RA) inducible gene transcription in the absence of RA. Previously, N-CoR was ...

journal_title：Mechanisms of development

authors： Xu F,Li K,Tian M,Hu P,Song W,Chen J,Gao X,Zhao Q

更新日期：2009-10-01 00:00:00

abstract：:We identified MRG-1, a Caenorhabditis elegans chromodomain-containing protein that is similar to the human mortality factor-related gene 15 product (MRG15). RNA-mediated interference (RNAi) of mrg-1 resulted in complete absence of the germline in both hermaphrodite and male adults. Examination of the expression of PGL...

journal_title：Mechanisms of development

authors： Fujita M,Takasaki T,Nakajima N,Kawano T,Shimura Y,Sakamoto H

更新日期：2002-06-01 00:00:00

abstract：:In the Drosophila embryo the nuclear localisation of Dorsal, a member of the Rel family, is regulated by an extracellular signal, which is transmitted to the interior of the egg cell by a cascade of proteins involving the novel protein Tube and the protein kinase Pelle. Here we analyse the activation mechanism of Tube...

journal_title：Mechanisms of development

authors： Grosshans J,Schnorrer F,Nüsslein-Volhard C

更新日期：1999-03-01 00:00:00

abstract：:The effects of signal perturbation on expression domains of molecular markers for the mesoderm and ectoderm have been analysed across the dorso-ventral axis in zebrafish embryos. Injection of RNA encoding bone morphogenetic protein-4 (BMP-4) ventralised the embryo, expanding the intermediate mesoderm and non-neural ec...

journal_title：Mechanisms of development

authors： Neave B,Holder N,Patient R

更新日期：1997-03-01 00:00:00

abstract：:The dual nature of pancreatic tissue permits both endocrine and exocrine functions. Enzymatic secretions by the exocrine pancreas help digestive processes while the pancreatic hormones regulate glucose homeostasis and energy metabolism. Pancreas organogenesis is defined by a conserved array of signaling pathways that ...

journal_title：Mechanisms of development

authors： Dumasia NP,Pethe PS

更新日期：2020-12-01 00:00:00

abstract：:Mice with targeted disruption of the TGF beta 2 gene display defects in epithelial-mesenchymal tissue interactions in several tissues including the developing cochlea. Specifically, the region of the spiral limbus and the overlying interdental cells, structures putatively involved in endolymphatic fluid homeostasis, d...

journal_title：Mechanisms of development

authors： Paradies NE,Sanford LP,Doetschman T,Friedman RA

更新日期：1998-12-01 00:00:00

abstract：:The Hedgehog (Hh) pathway was first defined by its role in segment polarity in the Drosophila melanogaster embryonic epidermis and has since been linked to many aspects of vertebrate development and disease. In humans, mutation of the Patched1 (PTCH1) gene, which encodes an inhibitor of Hh signaling, leads to tumors o...

journal_title：Mechanisms of development

authors： Kagey JD,Brown JA,Moberg KH

更新日期：2012-09-01 00:00:00

abstract：:Hox gene expression imparts segment identity to body structures along the anterior-posterior axis and is tightly governed by higher order chromatin mechanisms. Chromatin regulatory features of the homeotic complex are best defined in Drosophila melanogaster, where multiple cis-regulatory elements have been identified ...

journal_title：Mechanisms of development

authors： Srivastava S,Dhawan J,Mishra RK

更新日期：2015-11-01 00:00:00

abstract：:Formation of tubular structures from an epithelial tissue is a process common to many morphogenetic events during organogenesis. We report here new data concerning the expression pattern of the vHNF1/HNF1beta gene during this process in the mouse. vHNF1 (variant Hepatocyte Nuclear Factor 1) is a member of the HNF1 hom...

journal_title：Mechanisms of development

authors： Coffinier C,Barra J,Babinet C,Yaniv M

更新日期：1999-12-01 00:00:00

abstract：:In the developing eye of Drosophila the protein kinase D-Raf controls the specification of the R7 photoreceptor cells. We show that overexpression of wild-type D-Raf inhibits the formation of R7 cells in a dose-dependent manner. Conversely, overexpression of mutant D-Raf proteins in which the conserved S388 is replace...

journal_title：Mechanisms of development

authors： Rommel C,Radziwill G,Moelling K,Hafen E

更新日期：1997-06-01 00:00:00

abstract：:In mammals, the SWI/SNF complex is involved in chromatin remodelling in a wide range of cellular events for which regulatory factors require access to DNA. In the present study, we analyzed in early postimplantation mouse embryos the expression pattern of BRM (SNF2alpha) and BRG1 (SNF2beta), which are both ATPase subu...

journal_title：Mechanisms of development

authors： Dauvillier S,Ott MO,Renard JP,Legouy E

更新日期：2001-03-01 00:00:00

abstract：:In situ hybridization analysis of Xenopus laevis embryos reveals that mRNA encoding the platelet-derived growth factor alpha receptor (PDGFR alpha) is expressed in cephalic neural crest masses prior to migration from the future neural tube and during their migration into the visceral arches. The analysis of fluorescen...

journal_title：Mechanisms of development

authors： Ho L,Symes K,Yordán C,Gudas LJ,Mercola M

更新日期：1994-12-01 00:00:00

abstract：:In the process of cloning murine proteins capable of binding to a regulatory module of the Ncam promoter, we isolated a novel homeobox gene, Barx1, the first vertebrate member of the structural subclass defined by Drosophila BarH1. Here we report its sequence, chromosomal localisation and embryonic expression pattern....

journal_title：Mechanisms of development

authors： Tissier-Seta JP,Mucchielli ML,Mark M,Mattei MG,Goridis C,Brunet JF

更新日期：1995-05-01 00:00:00

abstract：:The spatial and temporal analysis of GATA-3 expression pattern in the human embryo revealed its expression in new anatomical sites. These include the endoderm of the primitive foregut, pharynx and allantois, the branchial arches and the mesenchymal cells surrounding the stomach and dorsal aorta. On the other hand, hum...

journal_title：Mechanisms of development

authors： Debacker C,Catala M,Labastie MC

更新日期：1999-07-01 00:00:00

abstract：:SIP1 encodes a DNA-binding transcription factor that regulates multiple developmental processes, as highlighted by the pleiotropic defects observed in Mowat-Wilson syndrome, which results from mutations in this gene. Further, in adults, dysregulated SIP1 expression has been implicated in both cancer and fibrotic disea...

journal_title：Mechanisms of development

authors： Manthey AL,Lachke SA,FitzGerald PG,Mason RW,Scheiblin DA,McDonald JH,Duncan MK

更新日期：2014-02-01 00:00:00

abstract：:The process of gastrulation is a pivotal step in the formation of the vertebrate body plan. The primary function of gastrulation is the correct placement of precursor tissues for subsequent morphogenesis. There is now mounting evidence that the body plan is established through inductive interactions between germ layer...

journal_title：Mechanisms of development

authors： Tam PP,Behringer RR

更新日期：1997-11-01 00:00:00

abstract：:Directional migration of primordial germ cells (PGCs) toward future gonads is a common feature in many animals. In zebrafish, mouse and chicken, SDF-1/CXCR4 chemokine signaling has been shown to have an important role in PGC migration. In Xenopus, SDF-1 is expressed in several regions in embryos including dorsal mesod...

journal_title：Mechanisms of development

authors： Takeuchi T,Tanigawa Y,Minamide R,Ikenishi K,Komiya T

更新日期：2010-01-01 00:00:00

abstract：:ZT3, isolated from a murine muscle cell cDNA library by a low-stringency hybridization, encodes a zinc finger domain containing factor with a transcript of 5.0 kb. A 3' 2.5 kb partial nucleotide sequence contains an ORF of 1.5 kb where 17 canonical C2H2 zinc finger domains organized in tandem were identified. It maps ...

journal_title：Mechanisms of development

authors： Polimeni M,Giorgi S,De Gregorio L,Dragani TA,Molinaro M,Cossu G,Bouché M

更新日期：1996-01-01 00:00:00

abstract：:The Notch effector E(spl)M8 is phosphorylated at Ser159 by CK2, a highly conserved Ser/Thr protein kinase. We have used the Gal4-UAS system to assess the role of M8 phosphorylation during bristle and eye morphogenesis by employing a non-phosphorylatable variant (M8SA) or one predicted to mimic the 'constitutively' pho...

journal_title：Mechanisms of development

authors： Karandikar UC,Trott RL,Yin J,Bishop CP,Bidwai AP

更新日期：2004-03-01 00:00:00

abstract：:Mammalian cell culture studies have shown that several members of the nuclear receptor super family such as glucocorticoid receptor, retinoic acid receptor and thyroid hormone receptor can repress the activity of AP-1 proteins by a mechanism that does not require the nuclear receptor to bind to DNA directly, but that ...

journal_title：Mechanisms of development

authors： Gritzan U,Weiss C,Brennecke J,Bohmann D

更新日期：2002-07-01 00:00:00

abstract：:Branching morphogenesis is a developmental process characteristic of many organ systems. Specifically, during renal branching morphogenesis, its been postulated that the final number of nephrons formed is one key clinical factor in the development of hypertension in adulthood. As it has been established that BMPs regu...

journal_title：Mechanisms of development

authors： Nikopoulos GN,Martins JF,Adams TL,Karaczyn A,Adams D,Vary C,Oxburgh L,Verdi JM

更新日期：2009-05-01 00:00:00

abstract：:The gene tprd, which contains three tetratricopeptide domains, has been recently localized in the Down syndrome (DS) chromosomal region 1. We have cloned a cDNA encoding part of the murine ortholog of tprd and used it to characterize the expression pattern of this gene during development and at the adult stage. At E8....

journal_title：Mechanisms of development

authors： Lopes C,Rachidi M,Gassanova S,Sinet PM,Delabar JM

更新日期：1999-06-01 00:00:00