Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila.

abstract：:The Drosophila homeobox gene engrailed (en) is needed for correct embryonic development, and related sequences are active during vertebrate embryogenesis. Here we report the protein coding sequence and embryonic expression pattern of the zebrafish engrailed-2 gene (eng-2) which is directly homologous to En-2 in mice a...

journal_title：Mechanisms of development

authors： Fjose A,Njølstad PR,Nornes S,Molven A,Krauss S

更新日期：1992-11-01 00:00:00

abstract：:A gene transfer method to ectopically express genes during chicken limb pattern formation using replication defective retroviral vectors has been established. Spherical non-proliferating (mitomycin C treated) aggregates of clonal retrovirus producing cells were grafted directly into developing chicken wing buds. The c...

journal_title：Mechanisms of development

authors： de la Pompa JL,Zeller R

更新日期：1993-10-01 00:00:00

abstract：:In order to analyze the expression pattern of the 5'-nucleotidase (5nt) gene in Dictyostelium, we made a fusion construct in which the 5nt promoter directed the expression of beta-galactosidase gene. The reporter gene was not active in vegetative amoebae but was expressed during the aggregation stage. At the slug stag...

journal_title：Mechanisms of development

authors： Ubeidat M,Eristi CM,Rutherford CL

更新日期：2002-01-01 00:00:00

abstract：:We describe the sequence and expression pattern of Sp5, a novel member of the vertebrate Sp1 transcription factor gene family which consists of at least five members. This gene family is characterized by a highly conserved domain which is formed by three Zn fingers, which bind to the GC box or the GT/CACC box in the p...

journal_title：Mechanisms of development

authors： Treichel D,Becker MB,Gruss P

更新日期：2001-03-01 00:00:00

abstract：:To examine the role of the Oct-6 gene in Schwann cell differentiation we have cloned and characterized the chicken and zebrafish homologues of the mouse Oct-6 gene. While highly homologous in the Pit1-Oct1/2-Unc86 (POU) domain, sequence similarities are limited outside this domain. Both genes are intronless and both p...

journal_title：Mechanisms of development

authors： Levavasseur F,Mandemakers W,Visser P,Broos L,Grosveld F,Zivkovic D,Meijer D

更新日期：1998-06-01 00:00:00

abstract：:The formation of mesoderm is an important developmental process of vertebrate embryos, which can be broken down into several steps; mesoderm induction, patterning, morphogenesis and differentiation. Although mesoderm formation in Xenopus has been intensively studied, much remains to be learned about the molecular even...

journal_title：Mechanisms of development

authors： Chen JA,Voigt J,Gilchrist M,Papalopulu N,Amaya E

更新日期：2005-03-01 00:00:00

abstract：:Compelling evidence from in vivo model systems within the past decade shows that the APP family of proteins is important for synaptic development and function in the central and peripheral nervous systems. The synaptic role promises to be complex and multifaceted for several reasons. The three family members have over...

journal_title：Mechanisms of development

authors： Caldwell JH,Klevanski M,Saar M,Müller UC

更新日期：2013-06-01 00:00:00

abstract：:In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein...

journal_title：Mechanisms of development

authors： Till DD,Linz B,Seago JE,Elgar SJ,Marujo PE,Elias ML,Arraiano CM,McClellan JA,McCarthy JE,Newbury SF

更新日期：1998-12-01 00:00:00

abstract：:DEADSouth was selected in a screen for localized RNAs in Xenopus oocytes. In situ hybridization analysis shows that DEADSouth localizes to the vegetal cortex via the mitochondrial cloud early in oogenesis and segregates with germ plasm during early embryogenesis. These results lend further support for the general conc...

journal_title：Mechanisms of development

authors： MacArthur H,Houston DW,Bubunenko M,Mosquera L,King ML

更新日期：2000-07-01 00:00:00

abstract：:The odd-skipped (odd) gene encodes a zinc finger protein that represses other segmentation genes in the early Drosophila embryo. Though odd is initially expressed in a striped pattern that reflects its function within the segmentation hierarchy, it is also expressed in a variety of patterns during later stages of embr...

journal_title：Mechanisms of development

authors： Ward EJ,Coulter DE

更新日期：2000-09-01 00:00:00

abstract：:Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult. The cDNA coding for zebrafish Egr1 was obtained and its expression pattern was examined during zebrafish embryogenesis using whole-mount in situ hybridization. Egr1 mRNA is first detec...

journal_title：Mechanisms of development

authors： Close R,Toro S,Martial JA,Muller M

更新日期：2002-10-01 00:00:00

abstract：:Mouse embryos lacking Gsc and Dkk1 function display severe deficiencies in craniofacial structures which are not found in either Dkk1 homozygous null or Gsc homozygous null mutant embryos. Loss of Gsc has a dosage-related effect on the severity of head truncation phenotype in Dkk1 heterozygous embryos. The synergistic...

journal_title：Mechanisms of development

authors： Lewis SL,Khoo PL,Andrea De Young R,Bildsoe H,Wakamiya M,Behringer RR,Mukhopadhyay M,Westphal H,Tam PP

更新日期：2007-02-01 00:00:00

abstract：:Recent work identified an apoptotic program in gastrulation stage Xenopus embryos (Anderson, J.A., Lewellyn, A.L., Maller, J.L., 1997. Mol. Biol. Cell 8, 1195-1206; Stack, J.H., Newport, J.W., 1997. Development 124, 3185-3195). Here, we characterize in detail this maternal cell death program, which is set up at fertil...

journal_title：Mechanisms of development

authors： Hensey C,Gautier J

更新日期：1997-12-01 00:00:00

abstract：:The idea has been put forward that molecules and mechanisms acting during development are re-used during regeneration in the adult, for example in response to traumatic injury in order to re-establish the functional integrity of neuronal circuits. Members of the Eph family of receptor tyrosine kinases and their 'ligan...

journal_title：Mechanisms of development

authors： Knöll B,Isenmann S,Kilic E,Walkenhorst J,Engel S,Wehinger J,Bähr M,Drescher U

更新日期：2001-08-01 00:00:00

abstract：:In Xenopus and zebrafish, BMP2, 4 and 7 have been implicated, after the onset of zygotic expression, in inducing and maintaining ventro-lateral cell fate during early development. We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in ze...

journal_title：Mechanisms of development

authors： Goutel C,Kishimoto Y,Schulte-Merker S,Rosa F

更新日期：2000-12-01 00:00:00

abstract：:Each sensory organ of the Drosophila peripheral nervous system is derived from a single sensory organ precursor cell (SOP). These originate in territories defined by expression of the proneural genes of the Achaete-Scute complex (AS-C). Formation of ectopic sensilla outside these regions is prevented by transcriptiona...

journal_title：Mechanisms of development

authors： Badenhorst P,Finch JT,Travers AA

更新日期：2002-09-01 00:00:00

abstract：:Early in the development of the imaginal wing disc of Drosophila, the LIM-HD gene tailup (islet), together with the HD genes of the iroquois complex, specify the notum territory of the disc. Later, tailup has been shown to act as a prepattern gene that antagonizes formation of sensory bristles on the notum of this fly...

journal_title：Mechanisms of development

authors： de Navascués J,Modolell J

更新日期：2010-09-01 00:00:00

abstract：:Myogenic regulatory factors (MRFs) are known to have essential roles in both the establishment and differentiation of the skeletal muscle cell lineage. MyoD is expressed early in the Xenopus mesoderm where it is present and active several hours before the activation of muscle differentiation genes. Previous studies in...

journal_title：Mechanisms of development

authors： McQueen C,Pownall ME

更新日期：2017-08-01 00:00:00

abstract：:Tubby is a mouse gene that may provide a model for adult-onset obesity in humans. It is a member of a four gene family in mammals that collectively encode the Tubby-like proteins (TULPs), putative transcription factors which share similar 260 amino acid 'tubby domains' at their C-termini. The mammalian genome also enc...

journal_title：Mechanisms of development

authors： Ronshaugen M,McGinnis N,Inglis D,Chou D,Zhao J,McGinnis W

更新日期：2002-09-01 00:00:00

abstract：:The Drosophila genes eyeless, eyes absent, sine oculis and dachshund cooperate as components of a network to control retinal determination. Vertebrate homologues of these genes have been identified and implicated in the control of cell fate. We present the cloning and characterization of mouse Dach2, a homologue of da...

journal_title：Mechanisms of development

authors： Davis RJ,Shen W,Sandler YI,Heanue TA,Mardon G

更新日期：2001-04-01 00:00:00

abstract：:The localization of RNAs at the vegetal cortex in Xenopus oocytes is a complex process, involving at least two different pathways. The early, or messenger transport organizer (METRO), pathway, localizes RNAs such as Xlsirts, Xcat2 and Xwnt11 during stages 1 and 2 of oogenesis, while the late pathway localizes RNAs suc...

journal_title：Mechanisms of development

authors： Kloc M,Etkin LD

更新日期：1998-04-01 00:00:00

abstract：:The Bar homeobox genes play an essential role during nervous system and eye development in Drosophila. We isolated a medaka Bar gene closely related to the Drosophila and mammalian Bar genes. In the medaka embryo, OlBar is expressed from gastrula stages onwards, in a region demarcating the presumptive prosencephalic-m...

journal_title：Mechanisms of development

authors： Poggi L,Carl M,Vignali R,Barsacchi G,Wittbrodt J

更新日期：2002-06-01 00:00:00

abstract：:Noelins are secreted glycoproteins with important developmental functions in frogs and birds. Here, we present the expression pattern of the mouse homolog of Noelin-1/2 at E8-10 of development and compare this pattern to other vertebrates. Expression was observed in the neural plate and neural crest, as well as in the...

journal_title：Mechanisms of development

authors： Moreno TA,Bronner-Fraser M

更新日期：2002-11-01 00:00:00

abstract：:Six genes are vertebrate homologues of the homeobox-containing gene sine oculis, which plays an essential role in controlling Drosophila compound eye development. Here we report the identification and expression patterns of all three subfamilies of Xenopus Six genes. Two Six2 subfamily genes (Six1, Six2) showed very s...

journal_title：Mechanisms of development

authors： Ghanbari H,Seo HC,Fjose A,Brändli AW

更新日期：2001-03-01 00:00:00

abstract：:Drosophila tracheal fusion cells play multiple important roles in guiding and facilitating tracheal branch fusion. Mechanistic understanding of how fusion cells function during development requires deciphering their transcriptional circuitry. In this paper, three genes with distinct patterns of fusion cell expression ...

journal_title：Mechanisms of development

authors： Jiang L,Pearson JC,Crews ST

更新日期：2010-05-01 00:00:00

abstract：:T-box genes constitute a conserved multi-gene family with important roles in many developmental processes. In this report, we describe the cloning and expression analysis of a novel mouse T-box gene, Tbx20. Expression is prominent in the extraembryonic mesoderm, in the developing heart, the eye anlage and motor neuron...

journal_title：Mechanisms of development

authors： Kraus F,Haenig B,Kispert A

更新日期：2001-01-01 00:00:00

abstract：:Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined P...

journal_title：Mechanisms of development

authors： Chang H,Matzuk MM

更新日期：2001-06-01 00:00:00

abstract：:Unlike gap genes in the trunk region of Drosophila embryos, gap genes in the head were presumed not to regulate each other's transcription. Here, we show that in tailless (tll) loss-of-function mutants the empty spiracles (ems) expression domain in the head expands, whereas it retracts in tll gain-of-function embryos....

journal_title：Mechanisms of development

authors： Hartmann B,Reichert H,Walldorf U

更新日期：2001-12-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:Members of the T-box (tbx) gene family encode developmentally regulated transcription factors, several of which are implicated in human hereditary diseases. We have cloned the paralogous genes tbx15 and tbx18 in zebrafish and have characterised their expression in detail. tbx15 is expressed in paraxial head mesenchyme...

journal_title：Mechanisms of development

authors： Begemann G,Gibert Y,Meyer A,Ingham PW

更新日期：2002-06-01 00:00:00