Tramtrack co-operates to prevent inappropriate neural development in Drosophila.

abstract：:Using the epidermis-specific cytokeratin 14 promoter to deliver HGF exclusively from epidermal keratinocytes, we have examined the potential of hepatocyte growth factor (HGF) secreted from the normal environment to control morphogenesis. The transgenic mice displayed a significant increase of the number of melanocytes...

journal_title：Mechanisms of development

authors： Kunisada T,Yamazaki H,Hirobe T,Kamei S,Omoteno M,Tagaya H,Hemmi H,Koshimizu U,Nakamura T,Hayashi SI

更新日期：2000-06-01 00:00:00

abstract：:Recent studies have shown that aberrantly expressed gastrin-releasing peptide (GRP) and its receptor (GRP-R) critically regulate tumor cell differentiation in colon cancers developing in humans and mice. This finding suggested that the ability of GRP/GRP-R to promote a well-differentiated phenotype in colon cancer mig...

journal_title：Mechanisms of development

authors： Carroll RE,Matkowskyj K,Saunthararajah Y,Sekosan M,Battey JF,Benya RV

更新日期：2002-05-01 00:00:00

abstract：:The development of multi-cellular organisms is regulated by the ordered definition of gene expression programmes that govern cell proliferation and differentiation. Although differential gene activity is mainly controlled by transcription factors, it is also dependent upon the underlying chromatin structure, which can...

journal_title：Mechanisms of development

authors： Czvitkovich S,Sauer S,Peters AH,Deiner E,Wolf A,Laible G,Opravil S,Beug H,Jenuwein T

更新日期：2001-09-01 00:00:00

abstract：:We isolated and characterized embryonic lethal mutations in piragua (prg). The prg locus encodes a protein with an amino terminus Zinc Finger-Associated-Domain (ZAD) and nine C2H2 zinc fingers (ZF). prg mRNA and protein expression during embryogenesis is dynamic with widespread maternal contribution, and subsequent ex...

journal_title：Mechanisms of development

authors： Nazario-Yepiz NO,Riesgo-Escovar JR

更新日期：2017-04-01 00:00:00

abstract：:Lobopodium is a hyaline cytoplasmic protrusion which rotates circumferencially around a cell. This movement is called circus movement, which is seen in dissociated cells of amphibian embryos. Relative abundance of the lobopodia-forming cells changes temporally and spatially within Xenopus embryos, reflecting stage-dep...

journal_title：Mechanisms of development

authors： Minoura I,Nakamura H,Tashiro K,Shiokawa K

更新日期：1995-01-01 00:00:00

abstract：:In Xenopus and zebrafish, BMP2, 4 and 7 have been implicated, after the onset of zygotic expression, in inducing and maintaining ventro-lateral cell fate during early development. We provide evidence here that a maternally expressed bone morphogenetic protein (BMP), Radar, may control early ventral specification in ze...

journal_title：Mechanisms of development

authors： Goutel C,Kishimoto Y,Schulte-Merker S,Rosa F

更新日期：2000-12-01 00:00:00

abstract：:Members of the TGFbeta superfamily of signalling molecules play important roles in mesendoderm induction and dorsoventral patterning of the vertebrate embryo. We cloned three intracellular mediators of TGFbeta signalling, smad1, 2 and 5, from the zebrafish. The three smad genes are expressed ubiquitously at the onset ...

journal_title：Mechanisms of development

authors： Müller F,Blader P,Rastegar S,Fischer N,Knöchel W,Strähle U

更新日期：1999-10-01 00:00:00

abstract：:Splotch mice, which harbour mutations in the Pax3 gene, exhibit neural crest-related abnormalities including pigmentation defects, reduced or absent dorsal root ganglia and failure of cardiac outflow tract septation in homozygotes. Although splotch neural crest cells fail to colonise target tissues, they initiate migr...

journal_title：Mechanisms of development

authors： Henderson DJ,Ybot-Gonzalez P,Copp AJ

更新日期：1997-12-01 00:00:00

abstract：:The mouse and human Hox complex consists of 39 genes in four linkage groups (A-D). Although the structure and expression patterns of most of these genes have been reported, the 5' members of the Hox C linkage group have been only partially characterized. Herein we report the primary and genomic structure of the mouse ...

journal_title：Mechanisms of development

authors： Hostikka SL,Capecchi MR

更新日期：1998-01-01 00:00:00

abstract：:Mutations in the renin-angiotensin system (RAS) genes are associated with congenital anomalies of the kidney and urinary tract (CAKUT). As angiotensin (Ang) II, the principal effector peptide growth factor of the RAS, stimulates ureteric bud (UB) branching in whole intact embryonic (E) metanephroi, defects in UB morph...

journal_title：Mechanisms of development

authors： Song R,Preston G,Yosypiv IV

更新日期：2011-09-01 00:00:00

abstract：:Retinoic acid plays important roles in development, growth and differentiation by regulating the expression of target genes. A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique. Stra6 codes for a very hydrophobic membr...

journal_title：Mechanisms of development

authors： Bouillet P,Sapin V,Chazaud C,Messaddeq N,Décimo D,Dollé P,Chambon P

更新日期：1997-05-01 00:00:00

abstract：:Endoreduplication cycles that lead to an increase of DNA ploidy and cell size occur in distinct spatial and temporal patterns during Drosophila development. Only little is known about the regulation of these modified cell cycles. We have investigated fore- and hindgut development and we present evidence that the Droso...

journal_title：Mechanisms of development

authors： Fuss B,Meissner T,Bauer R,Lehmann C,Eckardt F,Hoch M

更新日期：2001-01-01 00:00:00

abstract：:We previously showed that otx2 activates ectopic formation of the Xenopus cement gland only in ventrolateral ectoderm, defining a region of the embryo permissive for cement gland formation. In this paper, we explore the molecular identity of this permissive area. One candidate permissive factor is BMP4, whose putative...

journal_title：Mechanisms of development

authors： Gammill LS,Sive H

更新日期：2000-04-01 00:00:00

abstract：:Tetrapod fore-and hindlimbs have evolved from the pectoral and pelvic fins of an ancient vertebrate ancestor. In this ancestor, the pectoral fin appears to have arisen following the rostral homeotic recapitulation of an existing pelvic appendage (Tabin and Laufer (1993), Nature 361, 692-693). Thus the basic appendage ...

journal_title：Mechanisms of development

authors： Gibson-Brown JJ,Agulnik SI,Chapman DL,Alexiou M,Garvey N,Silver LM,Papaioannou VE

更新日期：1996-05-01 00:00:00

abstract：:The Retinal homeobox gene (Rx; also Rax) plays a crucial role in the early development of the vertebrate eye. Germline deletion of Rx in mice results in the failure of optic vesicle formation, leading to anophthalmia. Recent research using conditional mouse knockout models provides some clues to the role of Rx in eye ...

journal_title：Mechanisms of development

authors： Rodgers HM,Huffman VJ,Voronina VA,Lewandoski M,Mathers PH

更新日期：2018-06-01 00:00:00

abstract：:Vegetally localized RNAs in Xenopus oocytes have been implicated in the establishment of the primary germ layers and the formation and development of the primordial germ cells. fatvg mRNA is localized through the late pathway to the vegetal cortex. Like Vg1 mRNA fatvg is distributed throughout the entire cortex; howev...

journal_title：Mechanisms of development

authors： Chan AP,Kloc M,Bilinski S,Etkin LD

更新日期：2001-01-01 00:00:00

abstract：:Using a Drosophila cell-free system, we have analyzed the regulation of alternative splicing of Drosophila muscle myosin heavy chain (MHC) transcripts. Splicing of MHC 3' end transcripts results in exclusion of adult-specific alternative exon 18, as is observed in embryonic and larval muscle in vivo. Mutations that st...

journal_title：Mechanisms of development

authors： Hodges D,Bernstein SI

更新日期：1992-05-01 00:00:00

abstract：:Normal sexual differentiation in the genital organs is essential for the animal species that use sexual reproduction. Although it is known that doublesex (dsx) is required for the sexual development of the genitalia in various insect species, the direct target genes responsible for the sexual differentiation of the ge...

journal_title：Mechanisms of development

authors： Wagamitsu S,Takase D,Aoki F,Suzuki MG

更新日期：2017-02-01 00:00:00

abstract：:Mastermind, which is a Notch signal component, is a nuclear protein and is thought to contribute to the transactivation of target genes. Previously we showed that XMam1, Xenopus Mastermind1, was essential in the transactivation of a Notch target gene, XESR-1, and was involved in primary neurogenesis. To examine the fu...

journal_title：Mechanisms of development

authors： Katada T,Ito M,Kojima Y,Miyatani S,Kinoshita T

更新日期：2006-11-01 00:00:00

abstract：:The forkhead type Brain Factor 2 from mouse and chicken help pattern the forebrain, optic vesicle and kidney. We have isolated a Xenopus homolog (Xbf2) and found that during gastrulation it is expressed in the dorsolateral mesoderm, where it helps specify this territory by downregulating BMP-4 and its downstream genes...

journal_title：Mechanisms of development

authors： Gómez-Skarmeta JL,de la Calle-Mustienes E,Modolell J,Mayor R

更新日期：1999-01-01 00:00:00

abstract：:Preimplantation embryo development is an important and unique period and is strictly controlled. This period includes a series of critical events that are regulated by multiple signal-transduction pathways, all of which are crucial in the establishment of a viable pregnancy. The p38 mitogen-activated protein kinase (M...

journal_title：Mechanisms of development

authors： Sozen B,Ozturk S,Yaba A,Demir N

更新日期：2015-11-01 00:00:00

abstract：:The Drosophila genes eyeless, eyes absent, sine oculis and dachshund cooperate as components of a network to control retinal determination. Vertebrate homologues of these genes have been identified and implicated in the control of cell fate. We present the cloning and characterization of mouse Dach2, a homologue of da...

journal_title：Mechanisms of development

authors： Davis RJ,Shen W,Sandler YI,Heanue TA,Mardon G

更新日期：2001-04-01 00:00:00

abstract：:In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

journal_title：Mechanisms of development

authors： Nakamura Y,Matsuno K

更新日期：2003-08-01 00:00:00

abstract：:SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. S...

journal_title：Mechanisms of development

authors： Charbonnier F,Chanoine C,Cifuentes-Diaz C,Gallien CL,Rieger F,Alliel PM,Périn JP

更新日期：2000-02-01 00:00:00

abstract：:The recent development of transgenic methods for the frog Xenopus laevis provides the opportunity to study later developmental events, such as organogenesis, at the molecular level. Our studies have focused on the development of the tadpole gut, where tissue specific promoters have yet to be identified. We have used m...

journal_title：Mechanisms of development

authors： Beck CW,Slack JM

更新日期：1999-11-01 00:00:00

abstract：:Factors controlling the differentiation of the multipotent embryonic lung endoderm and mesoderm are poorly understood. Recent evidence that Delta-like 1 (Dll1) and other genes in the Notch/Delta signaling pathway are expressed in the embryonic mouse lung suggests that this pathway is important for cell fate decisions ...

journal_title：Mechanisms of development

authors： Post LC,Ternet M,Hogan BL

更新日期：2000-11-01 00:00:00

abstract：:Directional migration of primordial germ cells (PGCs) toward future gonads is a common feature in many animals. In zebrafish, mouse and chicken, SDF-1/CXCR4 chemokine signaling has been shown to have an important role in PGC migration. In Xenopus, SDF-1 is expressed in several regions in embryos including dorsal mesod...

journal_title：Mechanisms of development

authors： Takeuchi T,Tanigawa Y,Minamide R,Ikenishi K,Komiya T

更新日期：2010-01-01 00:00:00

abstract：:The Suppressor of forked (Su(f)) protein of Drosophila melanogaster is a homologue of the 77K subunit of human cleavage stimulation factor required for cleavage of pre-mRNAs before addition of poly(A). We have previously shown that the Su(f) protein is not ubiquitously distributed: it accumulates in dividing cells at ...

journal_title：Mechanisms of development

authors： Audibert A,Simonelig M

更新日期：1999-04-01 00:00:00

abstract：:To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...

journal_title：Mechanisms of development

authors： Ohuchi H,Kimura S,Watamoto M,Itoh N

更新日期：2000-07-01 00:00:00

abstract：:Xenopus embryos in solutions containing suramin show a dose-dependent decrease in the formation of dorsoanterior structures. Continuous treatment with 1 mM suramin produces embryos without mesodermal derivatives but with mesenchymal cells. Brief immersions of 20 min were used to determine the most sensitive stages and...

journal_title：Mechanisms of development

authors： Cardellini P,Polo C,Coral S

更新日期：1994-01-01 00:00:00