Xenopus frizzled 4 is a maternal mRNA and its zygotic expression is localized to the neuroectoderm and trunk lateral plate mesoderm.

abstract：:The availability of the draft sequence of the chicken genome will undoubtedly propel an already important vertebrate research model, the domestic chicken, to a new level. This review describes aspects of chicken natural history and cross-disciplinary biological value. The diversity of extant genetic variants available...

journal_title：Mechanisms of development

authors： Delany ME

更新日期：2004-09-01 00:00:00

abstract：:In the Drosophila embryo, a subset of muscles require expression and function of the RYK subfamily RTK gene derailed (drl) for correct attachment. We have isolated a second RYK homolog, doughnut (dnt), from Drosophila. The DNT protein exhibits 60% amino acid identity to DRL, and is structurally as similar to the mamma...

journal_title：Mechanisms of development

authors： Oates AC,Bonkovsky JL,Irvine DV,Kelly LE,Thomas JB,Wilks AF

更新日期：1998-11-01 00:00:00

abstract：:A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implica...

journal_title：Mechanisms of development

authors： Baumgartner S,Noll M

更新日期：1990-12-01 00:00:00

abstract：:The maturation of T cells is an intricate process involving the interaction of developing thymocytes with discrete microenvironments within the thymus. Numerous studies have indicated that distinct thymic compartments provide signals required for each stage of thymocyte maturation. In this study we performed a compreh...

journal_title：Mechanisms of development

authors： Vergara-Silva A,Schaefer KL,Berg LJ

更新日期：2002-12-01 00:00:00

abstract：:The Ras protein activates at least three different pathways during early development. Two of them regulate mesodermal gene expression and the third is thought to participate in the control of actin cytoskeleton dynamics via the Ral protein. From a yeast two-hybrid screen of a Xenopus maternal cDNA library, we identifi...

journal_title：Mechanisms of development

authors： Lebreton S,Boissel L,Iouzalen N,Moreau J

更新日期：2004-12-01 00:00:00

abstract：:Compelling evidence from in vivo model systems within the past decade shows that the APP family of proteins is important for synaptic development and function in the central and peripheral nervous systems. The synaptic role promises to be complex and multifaceted for several reasons. The three family members have over...

journal_title：Mechanisms of development

authors： Caldwell JH,Klevanski M,Saar M,Müller UC

更新日期：2013-06-01 00:00:00

abstract：:The sex determining gene, Sry, determines the sex of the organism by initiating development of a testis rather than an ovary from the cells of the bipotential gonad. In the 10 years since the discovery of Sry, new genes and cellular pathways that operate in the establishment of the gonadal primordium and the initiatio...

journal_title：Mechanisms of development

authors： Capel B

更新日期：2000-03-15 00:00:00

abstract：:Smad5, together with Smad1 and Smad8, have been implicated as downstream signal mediators for several bone morphogenetic proteins (BMPs). Recent studies have shown that primordial germ cells (PGCs) are absent or greatly reduced in Bmp4 or Bmp8b mutant mice. To define the role of Smad5 in PGC development, we examined P...

journal_title：Mechanisms of development

authors： Chang H,Matzuk MM

更新日期：2001-06-01 00:00:00

abstract：:We investigated the expression pattern of the endothelin-A receptor and endothelin 1 genes, the mutations of which affect the development of the mesectodermal derivatives of the neural crest. We show here that endothelin 1 is expressed by the environment of the cephalic neural crest cells invading branchial arches. La...

journal_title：Mechanisms of development

authors： Nataf V,Grapin-Botton A,Champeval D,Amemiya A,Yanagisawa M,Le Douarin NM

更新日期：1998-07-01 00:00:00

abstract：:During Drosophila eye development, cell differentiation is preceded by the formation of a morphogenetic furrow, which progresses across the epithelium from posterior to anterior. Cells within the morphogenetic furrow are apically constricted and shortened along their apical-basal axis. However, how these cell shape ch...

journal_title：Mechanisms of development

authors： Schlichting K,Dahmann C

更新日期：2008-08-01 00:00:00

abstract：:The Bar homeobox genes play an essential role during nervous system and eye development in Drosophila. We isolated a medaka Bar gene closely related to the Drosophila and mammalian Bar genes. In the medaka embryo, OlBar is expressed from gastrula stages onwards, in a region demarcating the presumptive prosencephalic-m...

journal_title：Mechanisms of development

authors： Poggi L,Carl M,Vignali R,Barsacchi G,Wittbrodt J

更新日期：2002-06-01 00:00:00

abstract：:Cell fate specification during inner ear development is dependent upon regional gene expression within the otic vesicle. One of the earliest cell fate determination steps in this system is the specification of neural precursors, and regulators of this process include the Atonal-related basic helix-loop-helix genes, Ng...

journal_title：Mechanisms of development

authors： Friedman RA,Makmura L,Biesiada E,Wang X,Keithley EM

更新日期：2005-05-01 00:00:00

abstract：:Growth is confined within a size that is normal for each species, revealing that somehow an organism 'knows' when this size has been reached. Within a species, growth is also variable, but despite this, proportion and structure are maintained. Perhaps, the key element in the control of size is the control of cell numb...

journal_title：Mechanisms of development

authors： Hidalgo A,ffrench-Constant C

更新日期：2003-11-01 00:00:00

abstract：:The expression pattern of the receptor tyrosine kinase gene EphB3 was examined during the early stages of chick embryogenesis, and is described in this report. In the gastrula, EphB3 is expressed in epiblast cells adjacent to and entering the anterior portion of the primitive streak; expression is extinguished once ce...

journal_title：Mechanisms of development

authors： Baker RK,Vanderboom AK,Bell GW,Antin PB

更新日期：2001-06-01 00:00:00

abstract：:Cadherins are Ca(+2)-dependent cell surface proteins involved in the specification of the adhesive properties of cells. They are supposed to play a critical role in morphogenesis and pattern formation. In this paper we show that in the sea urchin embryo there are at least two different cadherins of relative molecular ...

journal_title：Mechanisms of development

authors： Ghersi G,Salamone M,Dolo V,Levi G,Vittorelli ML

更新日期：1993-04-01 00:00:00

abstract：:dkk-1 has recently been identified as a secreted protein in Xenopus laevis which is sufficient and necessary to cause head induction by antagonizing Wnt signalling (Glinka et al., 1998, Nature 391, 357-362). Consistent with such a role dkk-1 is expressed in the Spemann organizer of the early frog gastrula. Later, expr...

journal_title：Mechanisms of development

authors： Grotewold L,Theil T,Rüther U

更新日期：1999-12-01 00:00:00

abstract：:Members of the cysteine-rich protein (CRP) define a subclass of LIM-only proteins implicated mainly in muscle differentiation. Until now, very little is known concerning the expression of CRP encoding genes during vertebrate development. We describe here the isolation of a trout (Oncorhynchus mykiss) gene encoding a c...

journal_title：Mechanisms of development

authors： Delalande JM,Rescan PY

更新日期：1998-08-01 00:00:00

abstract：:Terminal portions of the Drosophila body pattern are specified by an extracellular ligand generated at each end of the early syncytial embryo. This ligand triggers the localized transcription of two gap segmentation genes, tailles (tll) and huckebein (hkb) through a signal transduction cascade involving the receptor t...

journal_title：Mechanisms of development

authors： Casanova J,Llimargas M,Greenwood S,Struhl G

更新日期：1994-10-01 00:00:00

abstract：:The SRY-related, HMG box SoxB1 transcription factors are highly homologous, evolutionarily conserved proteins that are expressed in neuroepithelial cells throughout neural development. SoxB1 genes are down-regulated as cells exit the cell-cycle to differentiate and are considered functionally redundant in maintaining ...

journal_title：Mechanisms of development

authors： Rogers CD,Harafuji N,Archer T,Cunningham DD,Casey ES

更新日期：2009-01-01 00:00:00

abstract：:Three homeobox genes, one from Drosophila melanogaster (Drosophila Hmx gene) and two from mouse (murine Hmx2 and Hmx3) were isolated and the full-length cDNAs and corresponding genomic structures were characterized. The striking homeodomain similarity encoded by these three genes to previously identified genes in sea ...

journal_title：Mechanisms of development

authors： Wang W,Lo P,Frasch M,Lufkin T

更新日期：2000-12-01 00:00:00

abstract：:The expression pattern of K(+) currents is the principal regulator of electrical activity during development of the nervous and muscular system. We report here a study showing the expression pattern of HERG K(+) currents-encoding (erg) genes in various nervous and muscular tissues at different stages of quail embryo d...

journal_title：Mechanisms of development

authors： Crociani O,Cherubini A,Piccini E,Polvani S,Costa L,Fontana L,Hofmann G,Rosati B,Wanke E,Olivotto M,Arcangeli A

更新日期：2000-07-01 00:00:00

abstract：:To elucidate roles of fibroblast growth factors (FGF)18 during vertebrate development, we examined expression patterns of Fgf18 in chick embryos and observed effects of FGF18 protein on the Hensen's node, isthmus, and limb buds. Fgf18 is expressed on the right side of the node before the expression of Fgf8 starts. FGF...

journal_title：Mechanisms of development

authors： Ohuchi H,Kimura S,Watamoto M,Itoh N

更新日期：2000-07-01 00:00:00

abstract：:HNF1 (Hepatic Nuclear Factor 1) and vHNF1 are transcriptional regulators containing a highly divergent homeodomain. The first was initially found in liver nuclear extracts and is crucial for the transcription of albumin and many other hepatocyte specific genes, while the second was found in dedifferentiated hepatoma c...

journal_title：Mechanisms of development

authors： Ott MO,Rey-Campos J,Cereghini S,Yaniv M

更新日期：1991-12-01 00:00:00

abstract：:The Mix/Bix family of Pax-like homeodomain transcription factors is expressed early in vertebrate development and play important roles in endoderm and mesoderm formation. Like other Pax-related homeodomain proteins, the Mix/Bix family binds DNA as monomers or dimers and dimerization is mediated by the homeodomain. Whi...

journal_title：Mechanisms of development

authors： Doherty JR,Zhu H,Kuliyev E,Mead PE

更新日期：2006-01-01 00:00:00

abstract：:In Drosophila melanogaster, the patterning of dorsal appendages on the eggshell is strictly controlled by EGFR signaling. However, the number of dorsal appendages is remarkably diverse among Drosophila species. For example, D. melanogaster and D. virilis have two and four dorsal appendages, respectively. Here we show ...

journal_title：Mechanisms of development

authors： Nakamura Y,Matsuno K

更新日期：2003-08-01 00:00:00

abstract：:In a large-scale gene expression screen 1765 randomly picked cDNAs were analyzed by whole-mount in situ hybridization in Xenopus embryos. Two hundred and seventy three unique, differentially expressed genes were identified, 204 of which are novel in Xenopus. Partial DNA sequences and expression patterns were documente...

journal_title：Mechanisms of development

authors： Gawantka V,Pollet N,Delius H,Vingron M,Pfister R,Nitsch R,Blumenstock C,Niehrs C

更新日期：1998-10-01 00:00:00

abstract：:Epimorphic regeneration is a process allowing the animal to regain its lost structure which depends on the resident pluripotent stem cells as well as de-differentiation of existing cells to form multi-potent stem cells. Many studies have been done to understand the appendage regeneration mechanism. The animal model us...

journal_title：Mechanisms of development

authors： Murawala H,Ranadive I,Patel S,Desai I,Balakrishnan S

更新日期：2018-04-01 00:00:00

abstract：:The spatial and temporal expression of seven Drosophila protein tyrosine phosphatase genes during oogenesis was examined by whole mount in-situ hybridization of antisense RNA probes to ovaries. Our observations indicate diverse expression patterns consistent with multiple roles for protein tyrosine phosphatases in the...

journal_title：Mechanisms of development

authors： Fitzpatrick KA,Gorski SM,Ursuliak Z,Price JV

更新日期：1995-10-01 00:00:00

abstract：:The recessive mutant mouse jumonji (jmj), obtained by a gene trap strategy, shows neural tube defects in approximately half of homozygotes with a Balb/cA and 129/Ola mixed background. Here, we show that no neural tube defects are observed with a Balb/cA background. We also found hypoplasia of the liver, thymus and spl...

journal_title：Mechanisms of development

authors： Motoyama J,Kitajima K,Kojima M,Kondo S,Takeuchi T

更新日期：1997-08-01 00:00:00

abstract：:SPOCK is a modular proteoglycan, with homology with proteins involved in cell adhesion processes and neurogenesis. We have previously shown that SPOCK transcripts predominate in the adult mouse brain. Here, we report its expression during mouse embryonic development by in situ hybridization, and immunocytochemistry. S...

journal_title：Mechanisms of development

authors： Charbonnier F,Chanoine C,Cifuentes-Diaz C,Gallien CL,Rieger F,Alliel PM,Périn JP

更新日期：2000-02-01 00:00:00