Abstract:
:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of dopamine and norepinephrine, and therefore is of significant interest as a candidate gene in studies of affective disorders. We have carried out the linkage study between the susceptibility gene for affective disorder and tetranucleotide polymorphism of TH gene in five Japanese pedigrees. In addition to the linkage approach, we have undertaken an allelic association study using 74 patients with affective disorder and 78 controls with polymorphisms at the TH gene and the nearby dopamine D4 receptor gene. No evidence for linkage or associations were found. These results indicate that TH gene is less likely to contribute to the genetic component of affective disorders.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Kawada Y,Hattori M,Fukuda R,Arai H,Inoue R,Nanko Sdoi
10.1016/0165-0327(95)00004-7subject
Has Abstractpub_date
1995-05-17 00:00:00pages
89-94issue
2eissn
0165-0327issn
1573-2517pii
0165032795000047journal_volume
34pub_type
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2001-10-01 00:00:00
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