Abstract：
BACKGROUND:Syndromes of fear/anxiety are currently ill-defined, with no accepted human biomarkers for anxiety-specific processes. A unique common neural action of different classes of anxiolytic drugs may provide such a biomarker. In rodents, a reduction in low frequency (4-12 Hz; "theta") brain rhythmicity is produced by all anxiolytics (even those lacking panicolytic or antidepressant action) and not by any non-anxiolytics. This rhythmicity is a key property of the Behavioural Inhibition System (BIS) postulated to be one neural substrate of anxiety. We sought homologous anxiolytic-sensitive changes in human surface EEG rhythmicity. METHOD:Thirty-four healthy volunteers in parallel groups were administered double blind single doses of triazolam 0.25mg, buspirone 10mg or placebo 1 hour prior to completing the stop-signal task. Right frontal conflict-specific EEG power (previously shown to correlate with trait anxiety and neuroticism in this task) was extracted as a contrast between trials with balanced approach-avoidance (stop-go) conflict and the average of trials with net approach and net avoidance. RESULTS:Compared with placebo, both triazolam and buspirone decreased right-frontal, 9-10 Hz, conflict-specific-power. LIMITATIONS:Only one dose of each of only two classes of anxiolytic and no non-anxiolytics were tested, so additional tests are needed to determine generality. CONCLUSIONS:There is a distinct rhythmic system in humans that is sensitive to both classical/GABAergic and novel/serotonergic anxiolytics. This conflict-specific rhythmicity should provide a biomarker, with a strong pre-clinical neuropsychology, for a novel approach to classifying anxiety disorders.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
McNaughton N,Swart C,Neo P,Bates V,Glue Pdoi
10.1016/j.jad.2012.11.057subject
Has Abstractpub_date
2013-05-15 00:00:00pages
104-11issue
1eissn
0165-0327issn
1573-2517pii
S0165-0327(12)00824-5journal_volume
148pub_type
杂志文章,随机对照试验abstract：BACKGROUND:The anterior cingulate cortex (ACC) is a key region for the pathophysiology and treatment of depression. However, it remains unclear whether and how the morphology of the ACC is altered in subjects with mood disorders. METHOD:A post mortem morphometric study of the supragenual ACC (Brodmann area 24b) in sev...
journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2011.03.042
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abstract：:Interpersonal characteristics of the intimate partners of patients with non-melancholic depressive disorders were evaluated as potential predictors of outcome in an eighteen-month, longitudinal study. The short-term reduction in depressive symptoms was predicted most significantly by the patient's perception of the pa...
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abstract：BACKGROUND:Gene×environment (G×E) interactions are known to predict susceptibility to disorders such as depression and anxiety. Adverse experiences in childhood and number of stressful life events (SLEs) have been widely studied as environmental risk factors; however, SLE response has not yet been studied. Here we pres...
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abstract：BACKGROUND:Little is known about gender differences in the costs and outcomes of primary care quality improvement strategies for depression. METHODS:Intent-to-treat analysis of data from a group-level controlled trial, in which matched primary care clinics in the US were randomized to usual care or to one of two inter...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2005.03.018
更新日期：2005-08-01 00:00:00
abstract：:Daytime plasma cortisol levels in four rapid cycling bipolar affective disorder patients were measured longitudinally over multiple affective episodes, and changes in levels with mood state assessed for each individual patient. While three of the four patients had, as expected, increased cortisol levels during depress...
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doi：10.1016/0165-0327(87)90054-1
更新日期：1987-01-01 00:00:00
abstract：:This study examined the primary-secondary distinction with respect to DSM-IV alcohol use disorders and major depression in a large representative sample of the USA. Primary, secondary and concurrent depressives (i.e. the comorbid groups), respondents classified with major depression only and respondents classified wit...
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abstract：BACKGROUND:We investigated effects of current age and age at onset on symptomatology of depression with reference to proposed revisions in DSM-5. METHODS:The study entailed medical records of 326 inpatients diagnosed with major depressive disorder, including 520 depressive episodes, with 113 first episodes lifetime. S...
journal_title：Journal of affective disorders
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abstract：BACKGROUND:Women who have suffered from one episode of postpartum-onset major depression (PPMD) experience increased risk for recurrence in the year following another birth. METHODS:Non-depressed women (N=51) who had at least one past episode of PPMD were recruited during pregnancy. After birth, subjects were assessed...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00305-1
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
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journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
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abstract：BACKGROUND:Postnatal depression can have a major impact on the lives of women affected and on those around them. While effective treatments are available, it would be preferable to prevent the condition. The aim of this review was to examine the effectiveness of antenatal interventions designed to prevent postnatal dep...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2011.02.029
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Studies in animals showed that the hippocampus, a brain area involved in learning and memory, is sensitive to stress. Although several MRI studies showed smaller hippocampal volume in adults with chronic PTSD, others did not show significant differences from controls. These studies are typified by small samp...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.jad.2005.05.014
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range. METHOD:The GBI, the Schedule for Affective Disorders and Schizophrenia for School Age Children, Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and the Youth Self-Report (YSR) we...
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doi：10.1016/j.jad.2017.05.026
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The development of individual coping strategies for suicidal crises is essential for suicide prevention. However, the influence of a brief intervention and the effect on coping strategies is largely unknown. This study aimed to investigate the influence of the Attempted Suicide Short Intervention Program on ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.059
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.02.010
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journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
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更新日期：2004-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1994-11-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.12.040
更新日期：2014-03-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2014-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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更新日期：2010-07-01 00:00:00
