Abstract:
BACKGROUND:The anterior cingulate cortex (ACC) is a key region for the pathophysiology and treatment of depression. However, it remains unclear whether and how the morphology of the ACC is altered in subjects with mood disorders. METHOD:A post mortem morphometric study of the supragenual ACC (Brodmann area 24b) in seven subjects with mood disorder and nine comparison subjects. We measured glial and neuronal density, and neuronal size and shape. We also quantified the astrocytic marker, glial fibrillary acidic protein (GFAP), using immunoautoradiography. RESULTS:Cortical and layer thickness did not differ between groups. Subjects with mood disorder had a decreased density of glial cells across all layers, and a reduction in GFAP in white matter. The density of pyramidal neurons was decreased selectively in layer Vb, and their size was increased in layers V and VI. The shape of pyramidal neurons also differed in mood disorder, in layers Va and VI. CONCLUSION:These data provide further evidence for morphometric alterations in glia and pyramidal neurons in mood disorder. They represent a possible cellular basis for the aberrant functioning and connectivity of the ACC apparent from neuroimaging and other studies.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Gittins RA,Harrison PJdoi
10.1016/j.jad.2011.03.042subject
Has Abstractpub_date
2011-09-01 00:00:00pages
328-32issue
1-2eissn
0165-0327issn
1573-2517pii
S0165-0327(11)00141-8journal_volume
133pub_type
杂志文章abstract:OBJECTIVE:Somatic symptoms have been suggested to negatively affect the course of major depressive disorder (MDD). Mechanisms behind this association, however, remain elusive. This study examines the impact of somatic symptoms on MDD prognosis and aims to determine whether this effect can be explained by psychiatric ch...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.06.030
更新日期:2016-11-15 00:00:00
abstract::Epidemiological surveys demonstrate that unipolar depression is more common in females than in males. Gender-specific cultural and social factors may contribute to the female preponderance. This study explores this possibility in a cross-cultural sample of general-practice patients systematically recruited in the WHO ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/s0165-0327(98)00131-1
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:This study examined measurement variance for Autism Spectrum Disorder (ASD) in the Spence Children's Anxiety Scale - Parent Form (SCAS-P; Spence, 1999). In addition, we developed and evaluated a new parent report measure for anxiety (Macquarie Anxiety Behavioural Scale; MABS). METHOD:The sample consisted of ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.06.076
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Although the application of repetitive transcranial magnetic stimulation (rTMS) for treatment of depression has been well investigated, there are few biological predictors of clinical outcomes to rTMS treatment. Previous studies have suggested that the loudness dependence of auditory evoked potentials (LDAEP...
journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jad.2018.05.023
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:To examine whether racial/ethnic differences in receipt of MDD treatment could be explained by the specialty of provider diagnosing the adolescent. METHOD:Adolescents (10-20 years-old) with ≥2 MDD diagnoses were identified using 2005-2007 Medicaid data from Texas. Patients were categorized based on the type...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.04.045
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Higher depressive symptoms have been associated with lower future income. However, studies examining this issue have had limited follow-up times and have used self-reported measures of income. Also, possible confounders or mediators have not been accounted. METHODS:971 women and 738 men were selected from t...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.06.028
更新日期:2016-11-01 00:00:00
abstract::There is increasing evidence that besides the well-known angiotensin (Ang) II, other renin-angiotensin system (RAS) peptides, including Ang-(1-7), could have important effects at the central level. However, very few things are known about the central actions of Ang-(1-7), while the effects of its administration alone ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.07.024
更新日期:2013-02-20 00:00:00
abstract:BACKGROUND:The diagnosis of mania largely depends on the quality of information the physician is provided with. Often, the patient cannot give an accurate account of the symptom development and thus information from relatives and friends is required. No systematic rating instrument is available, however, to facilitate ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.07.022
更新日期:2010-04-01 00:00:00
abstract::Rates of depression are compared by sex in epidemiologic surveys conducted in the United States, Canada, Germany and New Zealand. These surveys used similar sampling and diagnostic techniques and the data were standardized to the age and sex distribution of the USA to facilitate comparisons. Data show that the rates o...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(93)90025-f
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Lifetime rates of depression are distinctly higher in women reflecting both real and artefactual influences. Most prevalence studies quantifying a female preponderance have examined severity-based diagnostic groups such as major depression or dysthymia. We examined gender differences across three depressive ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.06.018
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The uncertainty over the true morphological changes in brains with major depressive disorder (MDD) underlines the necessity of comprehensive studies with multimodal structural brain imaging analyses. This study aimed to evaluate the differences in cortical thickness, cortical and subcortical volume, and whit...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.10.021
更新日期:2014-02-01 00:00:00
abstract::Rates of depression among panic disorder patients are particularly elevated in patients with comorbid social phobia. However, it is unclear whether this association is specific to social phobia, or whether any comorbid anxiety disorder increases the risk of depression. We assessed 100 panic disorder patients and found...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(91)90051-s
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:Depressed mood, anhedonia, psychomotor retardation and alterations of circadian rhythm are core features of the depressive syndrome. Its neural correlates can be located within a frontal-striatal-tegmental neural network, commonly referred to as the reward circuit. It is the aim of this article to review lit...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2015.06.041
更新日期:2015-11-15 00:00:00
abstract:BACKGROUND:Visits to emergency departments (EDs) for suicidal ideation or a suicide attempt have increased in the past decades. Yet comprehensive models of suicide are scarce, potentially enhancing misunderstandings from health professionals. This study aimed to investigate the applicability of the interpersonal-psycho...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.12.049
更新日期:2017-03-01 00:00:00
abstract::Since (a) obsessive-compulsive disorder (OCD) may involve serotonergic neural transmission abnormalities also though to be related to regulation of suicide and aggression, (b) comorbidity between OCD and depression is substantial, and (c) depression is a major risk factor for suicide, a comprehensive analysis of clini...
journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/0165-0327(92)90054-a
更新日期:1992-01-01 00:00:00
abstract::Tricyclic antidepressants have multiple sites of pharmacological actions which are responsible for their tolerability and toxicological problems as well as their efficacy. That fact has prompted the search for antidepressants with fewer sites of action. That search resulted in the serotonin selective reuptake inhibito...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/s0165-0327(98)00222-5
更新日期:1998-12-01 00:00:00
abstract:BACKGROUND:Alterations of DNA methylation and expression of suicide-related genes occurring in specific brain's areas have been associated to suicidal behavior. In the BDNF pathway, TrkB gene in frontal cortex and hippocampus, and BDNF gene in Wernicke area have been found hypermethylated and down-regulated in suicide ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.07.003
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Is it healthy to be chaotic? Recent studies have argued that mental disorders are associated with more orderly neural activities, corresponding to a less flexible functional system. These conclusions were derived from altered temporal complexity. However, the relationship between spatial complexity and healt...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.12.107
更新日期:2019-03-01 00:00:00
abstract::104 patients in a cardiology clinic with atypical or non-anginal chest pain were studied through a structured clinical interview. 43 without coronary artery disease fit diagnostic criteria for panic disorder. 19 (44%) of this group reported a lifetime prevalence of major depression, nine (21%) current and ten (23%) pa...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(87)90073-5
更新日期:1987-07-01 00:00:00
abstract:BACKGROUND:Comorbidity of major depression with substance abuse increases the risk of committing suicide. The objective of this work was to determine the psychological and socio-demographic factors associated with depression and suicide attempts in patients rehabilitating for drug consumption. METHOD:57 Patients atten...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.07.033
更新日期:2014-12-01 00:00:00
abstract::To compare mortality in bipolar and unipolar manic-depressive patients, 2168 manic-depressive first admissions reported to the Danish Psychiatric Central Register were divided into a bipolar group (19%), i.e., patients with at least one admission for mania during an average observation period of six years, and a unipo...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(86)90074-1
更新日期:1986-11-01 00:00:00
abstract:OBJECTIVES:It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with the increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. METHODS:The 2001-2002 National Epidemiologic Survey ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.01.029
更新日期:2007-11-01 00:00:00
abstract::The plasma prolactin response to thyrotropin-releasing hormone, which is thought to be mediated by central 5-HT mechanisms, has been studied in patients with affective disorders. There was no difference between depressive patients (taken as a whole), bipolar patients undergoing a manic phase and controls in the prolac...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(80)90032-4
更新日期:1980-12-01 00:00:00
abstract:BACKGROUND:Ketamine has rapid-acting antidepressant and antisuicidal properties, while a proportion of patients do not adequately achieve a complete response to ketamine. Our aim was to explore the applicability of using clinical factors and serum tryptophan (TRP) metabolites to predict the response to six doses of ket...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.01.001
更新日期:2020-03-01 00:00:00
abstract:BACKGROUND:With the modification of DSM-5 mixed features specifier, a brief scale to screen mixed features in patients with mood disorders is needed in clinical practice. This study aimed to explore the psychometric properties of the Chinese version of the Clinically Useful Depression Outcome Scale supplemented with DS...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.09.117
更新日期:2021-01-15 00:00:00
abstract:BACKGROUND:There have been few studies which examined the developmental origins of cognitive vulnerability of depression. The purpose of the present study was to examine the effects of parental rearing on sociotropy and autonomy, the personality vulnerability factors in the cognitive theory of depression. METHODS:The ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.09.033
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects of prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) on obstetrical and neonatal outcomes. METHOD:A case-control study was conducted to compare perinatal outcomes among pregnant women with affective disorder (DSM-IV criteria) and who re...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.07.022
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Symptoms of depression and anxiety are common in children with obsessive-compulsive disorder (OCD) and associated with more severe OCD, greater impairment, and worse treatment outcome. Beyond twin studies showing that genetic factors contribute to the high co-occurrence, few studies have examined how OCD, de...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.03.090
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Depression is common in nursing-home patients and is often of chronic nature. AIMS:To examine the prevalence, incidence and the persistence rates of clinically significant depressive symptoms, and their risk factors among nursing-home patients. DESIGN:A 12 months follow-up study. METHODS:A sample of 902 r...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.04.028
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Adults with major depressive disorder (MDD) show elevated levels of IL-6 and TNF-alpha. Studies of adolescents with MDD or anxiety disorders (AD) are few and present conflicting results. METHODS:We studied plasma cytokines in a clinical sample of adolescent females with MDD and/or clinical AD (n=60, mean ag...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.10.002
更新日期:2012-02-01 00:00:00