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Neuroendocrine studies in affective disorders. Part 1. Plasma prolactin response to thyrotropin-releasing hormone in affective disorders: effect of ECT.

Abstract：

:The plasma prolactin response to thyrotropin-releasing hormone, which is thought to be mediated by central 5-HT mechanisms, has been studied in patients with affective disorders. There was no difference between depressive patients (taken as a whole), bipolar patients undergoing a manic phase and controls in the prolactin response to thyrotropin-releasing hormone. When the depressive patients were divided on a genetic basis into familial pure and sporadic depressive disease it was found that the sporadic patients had an enhanced response. The results do not provide any strong evidence to suggest that central 5-HT mechanisms as measured by the prolactin response to thyrotropin-releasing hormone are abnormal in depressed patients or bipolar patients undergoing a manic phase. Patients after ECT had an increased prolactin response to thyrotropin-releasing hormone which may indicate increased sensitivity of central 5-HT receptors following this treatment.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Coppen A,Rao VA,Bishop M,Abou-Saleh MT,Wood K

doi

10.1016/0165-0327(80)90032-4

subject

Has Abstract

pub_date

1980-12-01 00:00:00

pages

311-5

issue

4

eissn

0165-0327

issn

1573-2517

pii

0165-0327(80)90032-4

journal_volume

2

pub_type

杂志文章

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