Abstract:
BACKGROUND:Reduced plasma circular RNA DYM (circDYM) has been detected in patients with major depressive disorder (MDD). Mechanism research has demonstrated that circDYM, acting as a microRNA-9 sponge, suppressed microglial activation by increasing Heat Shock Protein 90 ubiquitination, indicating that circDYM could be a potential biomarker of MDD. METHODS:Thirty-two normal controls (NCs) and 60 MDD patients were recruited. Enrolled patients were randomly allocated to the real or sham repetitive transcranial magnetic stimulation (rTMS) group, followed by continuous five-day visual cortical rTMS or sham treatment. All participants underwent multidimensional neuropsychological assessments and detection of circDYM levels. RESULTS:Initial scores on all emotional and psychosocial assessments in MDD were significantly different from those of NCs. As compared with the NC group, baseline plasma circDYM levels in MDD patients decreased remarkably (p=0.030) and showed significant positive correlations with the scores of the 24-item Hamilton Depression Rating Scale (r=0.318, p=0.031) and retardation subscale (r=0.323, p=0.029). The increase in circDYM was noteworthy after rTMS (p=0.006), while downregulation with no statistical significance was observed after sham treatment (p=0.170). LIMITATIONS:It was not estimated on the correlation between plasma circDYM levels and long-term efficacy of rTMS. The mechanism of upregulated circDYM expression in response to visual cortical rTMS remained unrevealed, and the sample size was relatively small. CONCLUSIONS:This study verified the reduced circDYM levels in MDD patients, and further determined the upregulated circDYM expression after rTMS treatment, revealing the potential of circDYM as a biomarker for MDD diagnosis and antidepressant effect of visual cortical rTMS.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Song R,Bai Y,Li X,Zhu J,Zhang H,Shi Y,Li K,Wang B,Zhang H,Yang Y,Zhang Zdoi
10.1016/j.jad.2020.05.109subject
Has Abstractpub_date
2020-09-01 00:00:00pages
486-493eissn
0165-0327issn
1573-2517pii
S0165-0327(20)30155-5journal_volume
274pub_type
杂志文章abstract::This study used a matched clinician and self-rating scale, the Inventory for Depressive Symptomatology (IDS; Rush et al., 1986), in the assessment of 48 patients meeting DSM-III-R criteria for non-psychotic major depressive disorder. Patients generally rated their symptoms as more severe than the clinician, but differ...
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更新日期:1994-08-01 00:00:00
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更新日期:2014-10-01 00:00:00
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究
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更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Depression is one of the most common mental health problems in adolescents. A careful assessment of the prevalence and risk of depressive symptoms, as well as those factors that protect against it, is essential for prevention and intervention programs. METHOD:Using two waves of data from Grade 7 to Grade 9 ...
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pub_type: 杂志文章
doi:10.1016/j.jad.2020.05.034
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.11.033
更新日期:2019-02-15 00:00:00
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journal_title:Journal of affective disorders
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更新日期:2021-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
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更新日期:2003-09-01 00:00:00
abstract:BACKGROUND:Albeit obesity and mood disorders frequently co-occur, few studies examined the impacts of this co-occurrence. The aim was to compare individuals with obesity and mood disorders (ObMD) to those with obesity without mood disorder in terms of physical comorbidities, psychological well-being, health behaviours ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.06.014
更新日期:2011-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.07.022
更新日期:2010-04-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.jad.2018.02.009
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Depression is associated with a negative prognosis in coronary heart disease and heart failure patients. Type D personality has been shown to predict the persistence of depressive symptoms over 12 months. Data on longer follow-up periods and on the effectiveness of Type D as a screening tool compared to esta...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.11.044
更新日期:2012-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.jad.2020.12.178
更新日期:2020-12-30 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.03.042
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS:Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defi...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.09.003
更新日期:2019-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.07.066
更新日期:2019-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.06.031
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:The Edinburgh Postnatal Depression Scale (EPDS) was developed as a uni-dimensional measure of depression, however there is evidence that it also measures anxiety. This study examined the factor structure of the EPDS and validity of the identified subscales. METHOD:309 women with infants aged up to 12 months...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.02.004
更新日期:2009-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2014.05.009
更新日期:2014-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.01.029
更新日期:2008-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.09.030
更新日期:2016-01-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2016.06.028
更新日期:2016-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2008.09.002
更新日期:2009-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.05.034
更新日期:2012-12-20 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/0165-0327(80)90001-4
更新日期:1980-09-01 00:00:00
abstract:BACKGROUND:Preliminary data has shown temperament differences in workers of a few professions, particularly in artists. METHODS:3805 subjects (75.5% female, mean 32.4+/-9.8 years) of 23 broad professional areas answered a web-survey with the Combined Emotional and Affective Temperament Scale (CEATS). RESULTS:Educatio...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.03.020
更新日期:2010-10-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.12.001
更新日期:2011-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2006.02.023
更新日期:2006-07-01 00:00:00