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Role of lamotrigine in the management of treatment-resistant bipolar II depression: a chart review.

Abstract：

OBJECTIVES:We report the results of a retrospective, naturalistic study of lamotrigine in the management of treatment-resistant bipolar II depression. METHODS:Hospital charts of 31 patients treated at a mood disorders clinic, who had been on lamotrigine for at least six months after failing to show an adequate response to a combination of two mood stabilizers or a mood stabilizer and an antidepressant, were reviewed using the Clinical Global Impression-Improvement (CGI) rating scale. RESULTS:Patients were seen for an average of 19.4 months following the introduction of lamotrigine. The lamotrigine daily dose ranged from 50-400 mg (mean dose 199.2 mg) as monotherapy or in combination with a mood stabilizer, an atypical antipsychotic, or a sedative/hypnotic drug. Very much improvement was seen in 52% of patients and 32% were considered much improved. CONCLUSIONS:These naturalistic data suggest that lamotrigine alone or in combination with other psychotropic drugs was well tolerated and effective in the management treatment-resistant bipolar II depression. LIMITATIONS:Retrospective design, small sample size, and lack of a control group.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Sharma V,Khan M,Corpse C

doi

10.1016/j.jad.2008.01.029

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

100-5

issue

1

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(08)00059-1

journal_volume

111

pub_type

杂志文章

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