Abstract：
BACKGROUND:Transcranial direct current stimulation (tDCS) above the left dorsolateral prefrontal cortex (lDLPFC) has been widely used to improve symptoms of major depressive disorder (MDD). However, the effects of different stimulation protocols in the entire frontal lobe have not been investigated in a large sample including patient data. METHODS:We used 38 head models created from structural magnetic resonance imaging data of 19 healthy adults and 19 MDD patients and applied computational modeling to simulate the spatial distribution of tDCS-induced electric fields (EFs) in 20 frontal regions. We evaluated effects of seven bipolar and two multi-electrode 4 × 1 tDCS protocols. RESULTS:For bipolar montages, EFs were of comparable strength in the lDLPFC and in the medial prefrontal cortex (MPFC). Depending on stimulation parameters, EF cortical maps varied to a considerable degree, but were found to be similar in controls and patients. 4 × 1 montages produced more localized, albeit weaker effects. LIMITATIONS:White matter anisotropy was not modeled. The relationship between EF strength and clinical response to tDCS could not be evaluated. CONCLUSIONS:In addition to lDLPFC stimulation, excitability changes in the MPFC should also be considered as a potential mechanism underlying clinical efficacy of bipolar montages. MDD-associated anatomical variations are not likely to substantially influence current flow. Individual modeling of tDCS protocols can substantially improve cortical targeting. We make recommendations for future research to explicitly test the contribution of lDLPFC vs. MPFC stimulation to therapeutic outcomes of tDCS in this disorder.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Csifcsák G,Boayue NM,Puonti O,Thielscher A,Mittner Mdoi
10.1016/j.jad.2018.02.077subject
Has Abstractpub_date
2018-07-01 00:00:00pages
164-173eissn
0165-0327issn
1573-2517pii
S0165-0327(17)32474-6journal_volume
234pub_type
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