Noradrenergic and serotoninergic depression?

Abstract:

:The aim of this study was to test the hypothesis of noradrenergic and serotoninergic depressive subtypes. For this purpose, the correlation between three variables was investigated: urinary 3-methoxy-4-hydroxyphenylglycol (MHPG), dexamethasone suppression test (DST), and clinical response profiles to clomipramine and maprotiline, the effects of which are relatively selective on the uptake of noradrenaline (NA) and 5-hydroxytryptamine (5HT). Our results showed no correlation between these measures. Therefore, the hypothesis of two subtypes of depression was not supported. The only significant finding in this study was the obvious decrease in MHPG excretion during the antidepressant treatment in the group with high pretreatment MHPG.

journal_name

J Affect Disord

authors

Yazici O,Aricioğlu F,Gürvit G,Uçok A,Taştaban Y,Canberk O,Ozgüroğlu M,Durat T,Sahin D

doi

10.1016/0165-0327(93)90085-x

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

123-9

issue

2

eissn

0165-0327

issn

1573-2517

pii

0165-0327(93)90085-X

journal_volume

27

pub_type

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