Abstract:
BACKGROUND:Few prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research. METHOD:We investigated the association between spectral measures of resting HRV and depressive symptoms measured one year later, among 73 adolescents, aged 11-18 years. We evaluated (1) the predictive power of relative high frequency (HF) HRV, relative low frequency (LF) and relative very low frequency (VLF) HRV for depressive symptoms; and (2) the relative strength of association between HF HRV and depressive symptomatology (anhedonia, negative mood, interpersonal problems, ineffectiveness, negative self-esteem). RESULTS:HF HRV significantly predicted self-reported depressive symptoms across one year, controlling for age, puberty and sex. HF HRV was most strongly associated with anhedonia one year later, after considering other facets of depressive symptomatology. CONCLUSIONS:Results provide support for the prospective relationship between relative HF HRV and depressive symptoms among adolescents across one year. Findings concur with rodent models that suggest a specific link between HF HRV and anhedonia. LIMITATIONS:We investigated relative spectral power HF HRV and depressive symptom dimensions. We cannot make strong claims about these associations in clinical depression. Physical activity levels could be controlled in future work.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Vazquez L,Blood JD,Wu J,Chaplin TM,Hommer RE,Rutherford HJ,Potenza MN,Mayes LC,Crowley MJdoi
10.1016/j.jad.2016.02.040subject
Has Abstractpub_date
2016-05-15 00:00:00pages
243-7eissn
0165-0327issn
1573-2517pii
S0165-0327(15)31191-5journal_volume
196pub_type
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