Abstract：
:Major depression (MD) and bipolar disorder (BD) are severe and potentially life-threating mood disorders whose etiology is to date not completely understood. MicroRNAs (miRNAs) are small non-coding RNAs that regulate protein synthesis post-transcriptionally by base-pairing to target gene mRNAs. Growing evidence indicated that miRNAs might play a key role in the pathogenesis of neuropsychiatric disorders and in the action of psychotropic drugs. On these bases, in this study we evaluated the expression levels of 1733 mature miRNAs annotated in miRBase v.17, through a microarray technique, in the blood of 20 MD and 20 BD patients and 20 healthy controls, in order to identify putative miRNA signatures associated with mood disorders. We found that 5 miRNAs (hsa-let-7a-5p, hsa-let-7d-5p, hsa-let-7f-5p, hsa-miR-24-3p and hsa-miR-425-3p) were specifically altered in MD patients and 5 (hsa-miR-140-3p, hsa-miR-30d-5p, hsa-miR-330-5p, hsa-miR-378a-5p and hsa-miR-21-3p) in BD patients, whereas 2 miRNAs (hsa-miR-330-3p and hsa-miR-345-5p) were dysregulated in both the diseases. The bioinformatic prediction of the genes targeted by the altered miRNAs revealed the possible involvement of neural pathways relevant for psychiatric disorders. In conclusion, the observed results indicate a dysregulation of miRNA blood expression in mood disorders and could indicate new avenues for a better understanding of their pathogenetic mechanisms. The identified alterations may represent potential peripheral biomarkers to be complemented with other clinical and biological features for the improvement of diagnostic accuracy.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Maffioletti E,Cattaneo A,Rosso G,Maina G,Maj C,Gennarelli M,Tardito D,Bocchio-Chiavetto Ldoi
10.1016/j.jad.2016.04.021subject
Has Abstractpub_date
2016-08-01 00:00:00pages
250-8eissn
0165-0327issn
1573-2517pii
S0165-0327(16)30145-8journal_volume
200pub_type
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journal_title：Journal of affective disorders
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pub_type： 杂志文章,随机对照试验
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更新日期：2013-11-01 00:00:00
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更新日期：1983-05-01 00:00:00
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pub_type： 杂志文章
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