Abstract:
:Background Anxiety/depression and irritable bowel syndrome (IBS) are highly prevalent and burdensome conditions, whose co-occurrence is estimated between 44 and 84%. Shared gut microbiota alterations have been identified in these separate disorders relative to controls; however, studies have not adequately considered their comorbidity. This review set out to identify case-control studies comparing the gut microbiota in anxiety/depression, IBS, and both conditions comorbidly relative to each other and to controls, as well as gut microbiota investigations including measures of both IBS and anxiety/depression. Methods Four databases were systematically searched using comprehensive search terms (OVID Medline, Embase, PsycINFO, and PubMed), following PRISMA guidelines. Results Systematic review identified 17 studies (10 human, 7 animal). Most studies investigated the gut microbiota and anxiety/depression symptoms in IBS cohorts. Participants with IBS and high anxiety/depression symptoms had lower alpha diversity compared to controls and IBS-only cohorts. Machine learning and beta diversity distinguished between IBS participants with and without anxiety/depression by their gut microbiota. Comorbid IBS and anxiety/depression also had higher abundance of Proteobacteria, Prevotella/Prevotellaceae, Bacteroides and lower Lachnospiraceae relative to controls. Limitations A large number of gut microbiota estimation methods and statistical techniques were utilized; therefore, meta-analysis was not possible. Conclusions Well-designed case-control and longitudinal studies are required to disentangle whether the gut microbiota is predicted as a continuum of gastrointestinal and anxiety/depression symptom severity, or whether reported dysbiosis is unique to IBS and anxiety/depression comorbidity. These findings may inform the development of targeted treatment through the gut microbiota for individuals with both anxiety/depression and IBS.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Simpson CA,Mu A,Haslam N,Schwartz OS,Simmons JGdoi
10.1016/j.jad.2020.01.124subject
Has Abstractpub_date
2020-04-01 00:00:00pages
429-446eissn
0165-0327issn
1573-2517pii
S0165-0327(19)32577-7journal_volume
266pub_type
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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pub_type: 杂志文章
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doi:10.1016/0165-0327(89)90065-7
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.jad.2018.10.087
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.02.012
更新日期:2009-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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更新日期:1993-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.09.033
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-10-01 00:00:00