A trajectory-based approach to understand the factors associated with persistent depressive symptoms in primary care.

Abstract:

BACKGROUND:Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is limited, making decisions about type, intensity, frequency and length of treatment and follow-up difficult. This study is aimed to identify depressive symptom trajectories and associated socio-demographic, co-morbidity, health service use and treatment factors to inform clinical care. METHODS:789 people scoring 16 or more on the CES-D recruited from 30 randomly selected Australian family practices. Depressive symptoms are measured using PHQ-9 at 3, 6, 9 and 12 months. RESULTS:Growth mixture modelling identified a five-class trajectory model as the best fitting (lowest Bayesian Information Criterion): three groups were static (mild (n=532), moderate (n=138) and severe (n=69)) and two were dynamic (decreasing severity (n=32) and increasing severity (n=18)). The mild symptom trajectory was the most common (n=532). The severe symptom trajectory group (n=69) differed significantly from the mild symptom trajectory group on most variables. The severe and moderate groups were characterised by high levels of disadvantage, abuse, morbidity and disability. Decreasing and increasing severity trajectory classes were similar on most variables. LIMITATIONS:Adult only cohort, self-report measures. CONCLUSIONS:Most symptom trajectories remained static, suggesting that depression, as it presents in primary care, is not always an episodic disorder. The findings indicate future directions for building prognostic models to distinguish those who are likely to have a mild course from those who are likely to follow more severe trajectories. Determining appropriate clinical responses based upon a likely depression course requires further research.

journal_name

J Affect Disord

authors

Gunn J,Elliott P,Densley K,Middleton A,Ambresin G,Dowrick C,Herrman H,Hegarty K,Gilchrist G,Griffiths F

doi

10.1016/j.jad.2012.12.021

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

338-46

issue

2-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(12)00854-3

journal_volume

148

pub_type

杂志文章
  • Prediction of antidepressant response in both 2.25xthreshold RUL and fixed high dose RUL ECT.

    abstract:UNLABELLED:Some forms of electroconvulsive therapy (ECT) can result in generalized seizures that lack efficacy, therefore physiological markers of treatment adequacy would be helpful. EEG measures of seizure quality, such as EEG regularity and post-ictal suppression, have largely supplanted seizure duration as a marker...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2008.03.030

    authors: Kimball JN,Rosenquist PB,Dunn A,McCall WV

    更新日期:2009-01-01 00:00:00

  • Changes in method specific suicide following a national pesticide ban in India (2011-2014).

    abstract:BACKGROUND:This paper investigates whether declines in suicide by insecticide poisoning in India following a national ban on endosulfan in 2011were associated with changes in other methods of suicide and total suicide rates. METHOD:Method-specific suicide rates between 2001-2014 were calculated using National Crime Re...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.09.085

    authors: Arya V,Page A,Gunnell D,Armstrong G

    更新日期:2021-01-01 00:00:00

  • Effectiveness of a task-sharing collaborative care model for identification and management of depressive symptoms in patients with hypertension attending public sector primary care clinics in South Africa: pragmatic parallel cluster randomised controlled

    abstract:BACKGROUND:We tested the real-world effectiveness of a collaborative task-sharing model on depressive symptom reduction in hypertensive Primary Health Care (PHC) patients in South Africa. METHOD:A pragmatic parallel cluster randomised trial in 20 clinics in the Dr Kenneth Kaunda district, North West province. PHC clin...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.12.123

    authors: Petersen I,Fairall L,Zani B,Bhana A,Lombard C,Folb N,Selohilwe O,Georgeu-Pepper D,Petrus R,Mntambo N,Kathree T,Bachmann M,Levitt N,Thornicroft G,Lund C

    更新日期:2020-12-28 00:00:00

  • Low baseline salivary 3-methoxy-4-hydroxyphenylglycol (MHPG) in drug-naïve patients with short-illness-duration first episode major depressive disorder.

    abstract:BACKGROUND:Central noradrenergic dysfunction with autonomic nervous system dysregulation are reported in major depressive disorder (MDD). Salivary 3-methoxy-4-hydroxyphenylglycol (sMHPG) is indicative of central noradrenergic activity. Studies on MHPG in bodily fluids are inconsistent and scarce data is available regar...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.02.041

    authors: Cubała WJ,Landowski J,Wielgomas B,Czarnowski W

    更新日期:2014-06-01 00:00:00

  • The relevance of oxidative stress status in first episode and recurrent depression.

    abstract::Oxidative and nitrosative stress (O&NS) could play an important role in the pathophysiology of major depression (MDD). The aim of the present work was to evaluate the specific activity of the main peripheral antioxidant defences (superoxide dismutase--SOD and glutathione peroxidase--GPX) and the level of malondialdehy...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.05.022

    authors: Stefanescu C,Ciobica A

    更新日期:2012-12-20 00:00:00

  • Transcriptomic and epigenomic biomarkers of antidepressant response.

    abstract:BACKGROUND:Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted. METHODS:We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2017.08.087

    authors: Belzeaux R,Lin R,Ju C,Chay MA,Fiori LM,Lutz PE,Turecki G

    更新日期:2018-06-01 00:00:00

  • Intact anger recognition in depression despite aberrant visual facial information usage.

    abstract:BACKGROUND:Previous literature has indicated abnormalities in facial emotion recognition abilities, as well as deficits in basic visual processes in major depression. However, the literature is unclear on a number of important factors including whether or not these abnormalities represent deficient or enhanced emotion ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2014.04.065

    authors: Clark CM,Chiu CG,Diaz RL,Goghari VM

    更新日期:2014-08-01 00:00:00

  • Secular trends in psychiatric diagnoses of suicide victims.

    abstract::Post-mortem psychiatric diagnoses are compared in two cohorts of male suicides from St. Louis (1956-1957) (Robins, 1981) and San Diego (1981-1982) (Rich et al., 1986). Similar structured interviews and diagnostic criteria had been used in both assessments. Substance/alcohol abuse has remained the major diagnosis in su...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(91)90059-2

    authors: Carlson GA,Rich CL,Grayson P,Fowler RC

    更新日期:1991-02-01 00:00:00

  • An examination of the structure of posttraumatic stress disorder in relation to the anxiety and depressive disorders.

    abstract::The nature and structure of posttraumatic stress disorder (PTSD) has been the subject of much interest in recent times. This research has been represented by two streams, the first representing a substantive body of work which focuses specifically on the factor structure of PTSD and the second exploring PTSD's relatio...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.02.011

    authors: Forbes D,Lockwood E,Elhai JD,Creamer M,O'Donnell M,Bryant R,McFarlane A,Silove D

    更新日期:2011-07-01 00:00:00

  • Clinical experience with phototherapy.

    abstract::Thirty subjects with seasonal affective disorder (SAD) and three subjects with a non-seasonal depression had a trial of phototherapy in an open assessment of the feasibility of phototherapy in clinical practice. 43% of the SAD subjects met the criteria for 'successful treatment', but none of the subjects with non-seas...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(90)90069-k

    authors: Stinson D,Thompson C

    更新日期:1990-02-01 00:00:00

  • The association between anti-inflammatory effects of long-term lithium treatment and illness course in Bipolar Disorder.

    abstract:INTRODUCTION:Altered levels of acute-phase proteins are often described in different conditions in BD. Nevertheless, data on the association between lithium treatment and inflammatory markers in the long-term course of BD are still missing. The aim of the study was to examine the long-term course of BD concerning long-...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.11.063

    authors: Queissner R,Lenger M,Birner A,Dalkner N,Fellendorf F,Bengesser S,Platzer M,Hamm C,Maget A,Reininghaus B,Ratzenhofer M,Schuller J,Mangge H,Kapfhammer HP,Reininghaus EZ

    更新日期:2021-02-15 00:00:00

  • Emotionally valenced stimuli impact response inhibition in those with substance use disorder and co-occurring anxiety and depression symptoms.

    abstract:BACKGROUND:Substance use disorder (SUD) is associated with impaired response inhibition. Given the deficits in emotion regulation associated with SUD, it is unclear if this impairment is exacerbated by emotionally valenced stimuli. Co-occurring conditions may further exacerbate these impairments as many co-occurring co...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.02.008

    authors: Legrand AC,Price M

    更新日期:2020-04-01 00:00:00

  • Increased heart rate in depressed subjects in spite of unchanged autonomic balance?

    abstract::A clinical study was conducted to examine the effects of depression on cardiac autonomic control. Cardiac autonomic control was measured in 26 nonmedicated patients (19 females) suffering from Major Depression, melancholic type, and in 26 age- and sex-matched normal controls. We measured heart rate and high frequency ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(97)00164-x

    authors: Moser M,Lehofer M,Hoehn-Saric R,McLeod DR,Hildebrandt G,Steinbrenner B,Voica M,Liebmann P,Zapotoczky HG

    更新日期:1998-03-01 00:00:00

  • Temporal trends in antidepressant prescribing to children in UK primary care, 2000-2015.

    abstract:BACKGROUND:The prevalence of antidepressant prescribing in children and adolescents increased steadily in the United States and parts of Europe between 2005 and 2012 despite regulatory safety warnings. Little is known about the characteristics of those being prescribed antidepressants for the first time. METHODS:A lon...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2016.12.047

    authors: Sarginson J,Webb RT,Stocks SJ,Esmail A,Garg S,Ashcroft DM

    更新日期:2017-03-01 00:00:00

  • Mixed states with predominant manic or depressive symptoms: baseline characteristics and 24-month outcomes of the EMBLEM cohort.

    abstract:BACKGROUND:While factors associated with mixed states have been extensively studied, data are scant regarding the clinical heterogeneity of mixed states. The EMBLEM study was a prospective, observational study on patients with manic and mixed states. We describe and compare baseline characteristics and 24-month clinica...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.09.021

    authors: Azorin JM,Baraille L,Gérard S,Bertsch J,Reed C,Lukasiewicz M

    更新日期:2013-04-25 00:00:00

  • Treatment-emergent mania in pediatric bipolar disorder: a retrospective case review.

    abstract:BACKGROUND:Pediatric bipolar disorder (BPD) can be misdiagnosed as a depressive, attention, conduct, or anxiety disorder and treatment with antidepressants and stimulants is common. Risk of adverse outcomes related to such treatment remains poorly defined. METHODS:We analyzed clinical records of 82 children (mean age ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2003.12.011

    authors: Faedda GL,Baldessarini RJ,Glovinsky IP,Austin NB

    更新日期:2004-10-01 00:00:00

  • Enduring effects of Preventive Cognitive Therapy in adults remitted from recurrent depression: A 10 year follow-up of a randomized controlled trial.

    abstract:BACKGROUND:Prevention of recurrence is a challenge in the management of major depressive disorder (MDD). The long-term effects of Preventive Cognitive Therapy (PCT) in preventing recurrence in MDD are not known. METHODS:A RCT comparing the addition of PCT to Treatment As Usual (TAU), versus TAU including patients with...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2015.06.048

    authors: Bockting CL,Smid NH,Koeter MW,Spinhoven P,Beck AT,Schene AH

    更新日期:2015-10-01 00:00:00

  • Reliability and validity of the DSM-IV diagnostic category of schizoaffective disorder: preliminary data.

    abstract:BACKGROUND:Concerns have been expressed about the reliability and validity of the DSM-IV criteria for schizoaffective disorder, but no systematic study has been published up to now. METHODS:The Cohen's kappa for the individual items of the DSM-IV definition of schizoaffective disorder, manic episode and major depressi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(99)00059-2

    authors: Maj M,Pirozzi R,Formicola AM,Bartoli L,Bucci P

    更新日期:2000-01-01 00:00:00

  • ERP evidence for emotional sensitivity in social anxiety.

    abstract:BACKGROUND:Emotional sensitivity involves the ability to recognize and interpret facial expressions. This is very important for interpersonal communication. Previous studies found differences in emotional sensitivity between high social anxiety (HSA) individuals and low social anxiety (LSA) individuals. However, the un...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.09.111

    authors: Cui L,Dong X,Zhang S

    更新日期:2021-01-15 00:00:00

  • Dysthymia and cyclothymia in psychiatric practice a century after Kraepelin.

    abstract::Kraepelin had a modern vision of affective illness. He hypothesized that affective recurrences arose from enduring dispositions of depressive, cyclothymic, irritable, or 'manic' types. These dispositions appeared as 'temperaments' in English translations of his work. In the extreme, such temperamental gloominess or mo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/s0165-0327(00)00347-5

    authors: Akiskal HS

    更新日期:2001-01-01 00:00:00

  • Characterisation of the prodrome to a first episode of psychotic mania: results of a retrospective study.

    abstract:BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2009.12.021

    authors: Conus P,Ward J,Lucas N,Cotton S,Yung AR,Berk M,McGorry PD

    更新日期:2010-08-01 00:00:00

  • Course of longitudinal psychosocial functioning in bipolar youth transitioning to adults.

    abstract:OBJECTIVES:Few studies have examined domain-specific psychosocial functioning in Bipolar Disorder (BD) youths. This prospective study examines (1) Interpersonal Relationships with Family; (2) Interpersonal Relationships with Friends; (3) School/Work; (4) Recreation; (5) Life Satisfaction, in BD youths. METHOD:A Course...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.03.016

    authors: Lee EJ,Hower H,Jones RN,Birmaher B,Strober M,Goldstein BI,Merranko J,Keller MB,Goldstein TR,Weinstock LM,Dickstein DP,Hunt JI,Diler RS,Ryan ND,Gill MK,Axelson D,Yen S

    更新日期:2020-05-01 00:00:00

  • Episode cycles with increasing recurrences in first-episode bipolar-I disorder patients.

    abstract:BACKGROUND:Preliminary review of a century of studies of the course of manic-depressive syndromes produced 40 reports, of which approximately one-third report evidence of shortening wellness intervals or cycle-lengths with more recurrences, and two-thirds did not. METHODS:We evaluated inter-episode intervals (cycle-le...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2011.08.037

    authors: Baldessarini RJ,Salvatore P,Khalsa HK,Imaz-Etxeberria H,Gonzalez-Pinto A,Tohen M

    更新日期:2012-01-01 00:00:00

  • Imbalanced spontaneous brain activity in orbitofrontal-insular circuits in individuals with cognitive vulnerability to depression.

    abstract:BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2016.03.001

    authors: Zhang X,Di X,Lei H,Yang J,Xiao J,Wang X,Yao S,Rao H

    更新日期:2016-07-01 00:00:00

  • Mental disorders in cancer suicides.

    abstract::Mental disorders among suicide victims who had suffered from cancer were investigated using psychological autopsy data on all suicides in Finland over 1 year. Retrospective DSM-III-R consensus diagnoses were assigned to all 60 cancer suicides and to 60 age- and sex-matched comparison suicides without a cancer history....

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(95)00047-x

    authors: Henriksson MM,Isometsä ET,Hietanen PS,Aro HM,Lönnqvist JK

    更新日期:1995-12-24 00:00:00

  • Psychophysiological correlates of patients with delusional misidentification syndromes and psychotic major depression.

    abstract:BACKGROUND:Psychotic major depression (PMD) and delusional misidentification syndromes (DMS) exhibit cognitive deficits. Since the P300 component of event-related potentials (ERPs) provides valuable information concerning cognition, we studied this component of ERPs in DMS and PMD patients. METHODS:Nine patients with ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/S0165-0327(03)00136-8

    authors: Papageorgiou CC,Alevizos B,Ventouras E,Kontopantelis E,Uzunoglu N,Christodoulou G

    更新日期:2004-08-01 00:00:00

  • Detection of Borna disease virus p24 RNA in peripheral blood cells from Brazilian mood and psychotic disorder patients.

    abstract:BACKGROUND:Borna disease virus (BDV) is a virus that naturally infects a broad range of warm-blooded animals. BDV is an enveloped virus, non-segmented, negative-stranded RNA genome and has an organization characteristic of a member of Bornaviridae in the order of Mononegavirale. In the present work we investigated the ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2005.10.008

    authors: Miranda HC,Nunes SO,Calvo ES,Suzart S,Itano EN,Watanabe MA

    更新日期:2006-01-01 00:00:00

  • Altered neural processing of reward and punishment in adolescents with Major Depressive Disorder.

    abstract:BACKGROUND:Altered reward and punishment function has been suggested as an important vulnerability factor for the development of Major Depressive Disorder (MDD). Prior ERP studies found evidence for neurophysiological dysfunctions in reinforcement processes in adults with MDD. To date, only few ERP studies have examine...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.01.017

    authors: Landes I,Bakos S,Kohls G,Bartling J,Schulte-Körne G,Greimel E

    更新日期:2018-05-01 00:00:00

  • Is cognitive performance associated with anxiety and depression in first-episode psychosis?

    abstract:BACKGROUND:In first-episode psychosis (FEP), symptoms of anxiety and depression are common. We examined whether cognitive performance is associated with these clinical measures in FEP during a one-year follow-up. METHODS:Young adults with non-affective FEP (n = 52) were assessed two months after their first psychiatri...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.11.161

    authors: Lindgren M,Birling H,Kieseppä T,Tuulio-Henriksson A

    更新日期:2020-02-15 00:00:00

  • Major depressive episodes and mortality in the Canadian household population.

    abstract:OBJECTIVE:To explore the association between major depressive episodes (MDE) and subsequent mortality in a representative sample of the general household population, with adjustment for other determinants of mortality. METHOD:The analysis used four datasets from the Canadian Community Health Survey (CCHS); the CCHS 1....

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.08.030

    authors: Patten SB,Williams JV,Bulloch AG

    更新日期:2019-01-01 00:00:00