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Demonstration of disturbed activity of orbitofrontal pyramidal neurons in depressed patients by the AgNOR staining method.

Abstract：

BACKGROUND:The aim to find the morphological biomarker of disturbed activity of the orbitofrontal cortex (OFC) in depression was approached by the karyometric analysis of pyramidal neurons. METHODS:The study was performed on paraffin-embedded brains from 19 depressed patients from both major depressive disorder (MDD) and bipolar disorder (BD) diagnostic groups, including 9 suicides, and 24 matched controls. The karyometric parameters of medial OFC layer III and V pyramidal neurons bilaterally were evaluated by argyrophilic nucleolar organiser region (AgNOR) silver staining method. RESULTS:The enlarged nuclear area was found in layer V pyramidal neurons in the right OFC in non-suicides compared to suicides and controls, which was most likely the effect of neuroleptics. The intra-group comparisons between the hemispheres suggest the disturbed orbitofrontal lateralisation in depressed patients (predominantly in suicides) with moderate distinctness of the MDD and the BD diagnostic groups. LIMITATIONS:A major limitation of this study is a relatively small number of cases. A further limitation is given by the lack of data on drug exposure across the whole lifespan. CONCLUSION:The results suggest disturbed activity of OFC pyramidal neurons in depression, distinct in suicide and the diagnostic groups of mood disorders. The non-suicidal patients seem to benefit from neuroleptics, which most likely increase the activity of the subpopulation of OFC pyramidal neurons.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Gos T,Krell D,Bielau H,Steiner J,Mawrin C,Trübner K,Brisch R,Bernstein HG,Jankowski Z,Bogerts B

doi

10.1016/j.jad.2009.02.012

subject

Has Abstract

pub_date

2009-11-01 00:00:00

pages

131-8

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(09)00080-9

journal_volume

118

pub_type

杂志文章

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