Abstract:
BACKGROUND:The objective of this study was to evaluate effectiveness of commonly used prophylactic treatments for bipolar disorder in a naturalistic setting and to explore factors associated with treatment response. METHODS:We reviewed charts of 120 patients with a confirmed diagnosis of bipolar I or bipolar II disorder. The sample consisted of 37 males and 83 females, in the age range of 20 to 81 years (mean age 45+/-14 years), treated at an outpatient psychiatry program in a teaching hospital. In contrast to controlled clinical trials, we did not exclude subjects with co-morbid conditions and/or substance abuse. Treatment outcome was evaluated using a scale for retrospective assessment of prophylactic treatment response. The scale rates the degree of improvement in the course of treatment weighted by the likelihood of response being attributable to the treatment. The inter-reliability of the assessments was good with concordance of ratings of 90% and weighted kappa of 0.8. RESULTS:Rates of full response to individual mood stabilizers were: lithium 30%, carbamazepine 0%, valproate 13%, lamotrigine 11%, and olanzapine 25%. Lithium responders were more likely to be bipolar II, and had a typically episodic course of illness with earlier onset in comparison with non-responders. Responders to valproate had higher rates of psychosis. LIMITATIONS:Data were obtained by chart reviews. CONCLUSIONS:Less than one-third of patients treated with lithium achieved remission; the effectiveness of other treatments in this naturalistic sample was even lower.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Garnham J,Munro A,Slaney C,Macdougall M,Passmore M,Duffy A,O'Donovan C,Teehan A,Alda Mdoi
10.1016/j.jad.2007.03.003subject
Has Abstractpub_date
2007-12-01 00:00:00pages
185-90issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(07)00099-7journal_volume
104pub_type
杂志文章abstract:BACKGROUND:Research showed that the perception of unmet needs may differ between patients, caregivers and professionals. Lacking agreement with regard to unmet needs between raters involved may have a negative impact on treatment of late-life depression. METHODS:As part of the multicenter German study "Late-life depre...
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doi:10.1016/j.jad.2016.07.001
更新日期:2016-11-15 00:00:00
abstract:BACKGROUND:Cardiorespiratory fitness (CRF) strongly influences health, but very little is known about the childhood determinants of adult CRF. Our longitudinal study investigated whether childhood psychopathology and socioeconomic status (SES) were related to adult CRF in 1647 Finnish male military conscripts. METHODS...
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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更新日期:2013-03-20 00:00:00
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journal_title:Journal of affective disorders
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更新日期:1991-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
abstract:BACKGROUND:Alexithymia is a problem of emotion regulation and for this reason alone may relate to suicidality. This article investigates the evidence for a direct relationship. It explores the possibility of an additional role for interoception in future research. METHODS:A scoping review of peer-reviewed journal arti...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/j.jad.2018.06.027
更新日期:2018-10-01 00:00:00
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journal_title:Journal of affective disorders
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更新日期:2003-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.02.042
更新日期:2019-04-15 00:00:00
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2014.10.040
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2016.05.047
更新日期:2016-09-15 00:00:00
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journal_title:Journal of affective disorders
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doi:10.1016/j.jad.2020.03.090
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Individual temperament is associated with psychiatric morbidity and could explain differences in psychiatric comorbidities. We investigated the association of temperament profile clusters with anxiety disorder comorbidity in patients with depression. METHODS:We assessed the temperament of 204 specialized ca...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.04.084
更新日期:2018-08-15 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.05.002
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Accurately identifying patients at an elevated risk of suicide in minimal time is an important mental health issue. Therefore, we developed the Ultra Brief Checklist for Suicidality (UBCS) and reported its psychometric properties. METHODS:We studied 544 participants who had completed the UBCS, other self-re...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.07.037
更新日期:2020-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.06.051
更新日期:2011-12-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.09.035
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2015.04.053
更新日期:2015-09-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 临床试验,杂志文章
doi:10.1016/j.jad.2018.12.048
更新日期:2019-03-01 00:00:00
abstract::We aimed to investigate the changes in serum adiponectin and resistin levels in patients with obsessive compulsive disorder and control groups. The serum adiponectin and resistin levels of 29 patients (16 females, 13 males) with obsessive compulsive disorder and weight, age and sex-matched 31 healthy controls (17 fema...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2011.07.029
更新日期:2012-02-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.08.007
更新日期:2020-01-15 00:00:00
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journal_title:Journal of affective disorders
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更新日期:1994-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2010.10.052
更新日期:2011-06-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.01.007
更新日期:2013-07-01 00:00:00
abstract:BACKGROUND:In order to experimentally asses the role of socio-emotional problems in Eating Disorder (ED) psychopathology, we have measured affective states and ED-related attitudes in response to an acute psychosocial stress and their relationships with interpersonal sensitivity in people with Anorexia Nervosa (AN) and...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.05.051
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:In recent years, efforts in suicide prevention in the United States and Europe have been made to change the conversation on suicide to incorporate more preventive aspects. The majority of information-seeking occurs online. Structured analyses assessing qualitative changes in retrieved online material on suic...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.03.063
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:Suicide attempters and suicide completers are two overlapping but distinct suicide populations. This study aims to present a more accurate characterization by comparing populations of suicide attempters and completers from the same geographical area. METHODS:Samples and procedure: All cases of attempted sui...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2013.03.013
更新日期:2013-09-25 00:00:00
abstract:BACKGROUND:Regular physical activity reduces the risk of depression onset and is an effective treatment for mood disorders. Recent studies have reported that sedentary behavior (SB) increases the risk of depression in adults, but relationships of different types of SBs with depression have not been examined systematica...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.08.020
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVES:It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with the increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. METHODS:The 2001-2002 National Epidemiologic Survey ...
journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2007.01.029
更新日期:2007-11-01 00:00:00
abstract::This article reports on the treatment received by 38 adolescents during an episode of major depression which had a median duration of 4 months. The one subject who received any pharmacologic treatment was prescribed an antianxiety agent. Sixteen percent received psychotherapy. These results are consistent with evidenc...
journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
doi:10.1016/0165-0327(91)90037-s
更新日期:1991-03-01 00:00:00