Depression in women with polycystic ovary syndrome: clinical and biochemical correlates.

Abstract:

BACKGROUND:We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS). METHODS:Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed. RESULTS:Sixteen women had CES-D scores indicative of depression. Depression was associated with greater insulin resistance (P=0.02) and higher body mass index (P=0.05). Women receiving oral contraceptives for the treatment of PCOS were less depressed than patients not receiving treatment (P=0.03). LIMITATIONS:Possible selection bias, use of a screening tool alone without further diagnostic evaluation of depression, small samples size and lack of direct comparison with an age matched control group, should be considered in interpretation of these results. CONCLUSION:Findings suggest a high prevalence of depression among women with PCOS, and an association between depression and PCOS markers.

journal_name

J Affect Disord

authors

Rasgon NL,Rao RC,Hwang S,Altshuler LL,Elman S,Zuckerbrow-Miller J,Korenman SG

doi

10.1016/s0165-0327(02)00117-9

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

299-304

issue

3

eissn

0165-0327

issn

1573-2517

pii

S0165032702001179

journal_volume

74

pub_type

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