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Vitamin D and depression.

Abstract：

OBJECTIVE:To examine whether vitamin D deficiency or insufficiency is associated with depression and whether vitamin D supplementation is an effective treatment for depression. METHOD:Empirical papers published in recent years were identified using three search engines and online databases - PubMed, Google Scholar and Cochrane Database. Specific search terms used were 'vitamin D', 'depression' and 'treatment' and articles were selected that examined the association between vitamin D deficiency/insufficiency and depression, vitamin D supplementation and Vitamin D as a treatment for depression. Our review weighted more recent studies (from 2011), although also considered earlier publications. RESULTS:Empirical studies appear to provide increasing evidence for an association between vitamin D insufficiency and depression, and for vitamin D supplementation and augmentation in those with clinical depression who are vitamin D deficient. Methodological limitations associated with many of the studies are detailed. LIMITATIONS:Articles were restricted to those in the English language while publication bias may have weighted studies with positive findings. CONCLUSIONS:There remains a need for empirical studies to move beyond cross-sectional designs to undertake more randomised controlled longitudinal trials so as to clarify the role of vitamin D in the pathogenesis of depression and its management, as well as to establish whether currently suggested associations are clinically significant and distinctive.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Parker GB,Brotchie H,Graham RK

doi

10.1016/j.jad.2016.08.082

subject

Has Abstract

pub_date

2017-01-15 00:00:00

pages

56-61

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(16)30892-8

journal_volume

208

pub_type

杂志文章,评审

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