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A double-blind double-dummy study of citalopram comparing infusion versus oral administration.

Abstract：

BACKGROUND:This study compares antidepressant efficacy and tolerability of citalopram given either orally or as a slow drop infusion. METHODS:Citalopram (40 mg/day) was administered double-blindly as tablets or slow-drop infusion during the first 10 days and then open, orally, up to treatment Day 42. RESULTS:In 60 moderately to severely depressed patients, the Hamilton depression total score (17-items) at baseline was 23.9 and 23.6 in the active infusion (n = 30) and active tablet (n = 30) group, respectively. These scores dropped in both groups to 15.6 and 16.9 on Day 10, and to 10.3 and 10.2 on Day 42. Response rates (delta Hamilton > or = 50%) amounted to 33.3% and 17.9% on Day 10, and 66.2% and 63.3% on Day 42, without a relevant group difference in citalopram plasma concentration. CONCLUSION:Slow-drop infusion with citalopram shows a similar risk/benefit relationship to oral citalopram. The design of this study allowed us to evaluate pharmacological but not psychological factors which may contribute to response to slow-drop infusion.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Baumann P,Nil R,Bertschy G,Jecker A,Brändli H,Morand J,Kasas A,Vuagniaux O,Ramseier F

doi

10.1016/s0165-0327(98)00024-x

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

203-10

issue

3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(98)00024-X

journal_volume

49

pub_type

临床试验,杂志文章,随机对照试验

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