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Effects of glucocorticoids on the regulation of the hypothalamic-pituitary-somatotropic system in depression.

Abstract：

:In order to evaluate the possible effect of glucocorticoids as neuromodulators of the hypothalamic-pituitary-somatotropic system in depression, cortisol, growth hormone (GH), and insulin-like growth factor I (IGF-I) concentrations were studied before and after oral administration of 1 mg dexamethasone at 11 p.m. in 16 patients during depression and after recovery and in 28 healthy controls. While there were no significant differences in GH and IGF-I levels between depressed, recovered and control subjects, GH and IGF-I concentrations of cortisol non-suppressors were significantly elevated compared to suppressors. Moreover, post-dexamethasone cortisol, GH, and IGF-I levels were positively correlated. Dexamethasone had a stimulating effect on GH and IGF-I values in patients during depression and in cortisol non-suppressors only; this effect was absent in recovered and in control subjects and in cortisol suppressors. Thus, hypercortisolemia may be of great importance for the dysregulation of the hypothalamic-pituitary-somatotropic system reported in depression.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Rupprecht R,Rupprecht C,Rupprecht M,Noder M,Lesch KP,Mössner J

doi

10.1016/0165-0327(89)90018-9

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

9-16

issue

1

eissn

0165-0327

issn

1573-2517

pii

0165-0327(89)90018-9

journal_volume

17

pub_type

杂志文章

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