当前位置： SCI文献检索 > JOURNAL OF AFFECTIVE DISORDERS期刊下所有文献 > History of suicide attempts among patients with depression in the GENDEP project.

History of suicide attempts among patients with depression in the GENDEP project.

Abstract：

BACKGROUND:It has been proposed that a history of suicide attempts could be a correlate of severe depressive disorder and that suicide attempters (SA) could represent a particular subtype of subjects suffering from major depressive disorder. We investigated clinical and demographic characteristics associated with SA and tested the hypothesis that a history of suicide attempts predicts poor response to antidepressants. METHODS:One-hundred-and-forty-one SA and 670 non-SA subjects with major depressive disorder (MDD) were treated for twelve weeks with escitalopram or nortriptyline in GENDEP, a part-randomized multi-center clinical and pharmacogenetic study. Baseline characteristics were compared using linear and logistic regression. Linear mixed models were used to analyse continuous outcomes during the twelve weeks of follow-up. RESULTS:At baseline, SA subjects suffered from more severe depression (mean Montgomery-Asberg Depression Rating Scale: 30.29 (7.61) vs 28.43 (6.54), p=0.0002), reported higher level of suicidal ideation (1.21 (0.82) vs 0.73 (0.48), p<0.0001), had a younger age of onset and experienced more depressive episodes, had higher harm avoidance scores and poorer socio-demographic environment than non-SA individuals. However, during the twelve weeks of treatment and after adjustment for baseline severity of depression there was no difference in treatment response between SA and non-SA. LIMITATIONS:Due to its retrospective design, it is possible that more severely depressed subjects might report more suicide attempts than less depressed individuals. CONCLUSIONS:While SA differed from non-SA in several clinical and demographic characteristics, the antidepressants were similarly effective in SA as in comparably severely depressed subjects without a history of suicide attempts.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Perroud N,Uher R,Hauser J,Rietschel M,Henigsberg N,Placentino A,Kozel D,Maier W,Mors O,Souery D,Dmitrzak-Weglarz M,Jorgensen L,Kovacic Z,Giovannini C,Mendlewicz J,Zobel A,Strohmaier J,McGuffin P,Aitchison KJ,Farmer

doi

10.1016/j.jad.2009.09.001

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

131-7

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(09)00419-4

journal_volume

123

pub_type

杂志文章,多中心研究,随机对照试验

在线工具

History of suicide attempts among patients with depression in the GENDEP project.