Abstract：
:Electrodermal hyporeactivity in the anticipation of aversive stimuli is a highly reliable correlate of diagnosed psychopathy and undersocialized aggressive conduct disorder (UACD), and it has been interpreted as reflecting a weak behavioral inhibition system (BIS) as conceptualized in Gray's work (e.g., in: Royce, J.R. (Ed.), Multivariate Analysis and Psychological Theory. Academic Press, New York, NY, p. 409, 1973). This interpretation predicts that electrodermal hyporeactivity should be associated with a single dimension of temperament involving both low anxiety and behavioral disinhibition. However, temperament scales identify separate dimensions of trait anxiety/neuroticism and inhibitory control, and most investigators have assumed that the BIS is associated with the trait anxiety/neuroticism dimension. The present review supports the view that electrodermal hyporeactivity is associated with both low anxiety and disinhibition, as expected, and, possibly, with poor control of emotional expression. Additionally, electrodermal hyporeactivity appears to relate to an impulsivity dimension among psychopaths rather than to the core personality features of psychopathy. Recent findings raise the possibility that psychopaths suffer from a broader deficit (sometimes described as an executive function deficit) than a weak BIS and that electrodermal hyporeactivity might relate to this broader deficit. It is proposed that problems with impulsivity are more strongly documented than the broader concept of executive function deficits and that a primary disinhibition can produce secondary executive function deficits. A disinhibitory deficit is consistent with the weak BIS hypothesis. Overall, the results appear to be consistent with the electrodermal hyporeactivity-weak BIS hypothesis, but many issues remain to be resolved.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Fowles DCdoi
10.1016/s0165-0327(00)00336-0subject
Has Abstractpub_date
2000-12-01 00:00:00pages
177-89issue
3eissn
0165-0327issn
1573-2517pii
S0165032700003360journal_volume
61pub_type
杂志文章,评审abstract：BACKGROUND:Compelling evidence links elevated levels of C-reactive protein (CRP) and other inflammatory markers to poor treatment outcome of antidepressant medication. Little is known about the contribution of low-grade inflammation to treatment response to electroconvulsive therapy (ECT) in severely depressed patients...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.06.040
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family and plays a critical role in growth, differentiation, maintenance and synaptic plasticity of neuronal systems. Previous studies have demonstrated lower serum BDNF concentrations in major depressive disorder (MDD), with con...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.06.041
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Bright artificial light improves non-seasonal depression. Preliminary observations suggest that sunlight could share this effect. METHODS:Length of hospitalization was recorded for a sample of 415 unipolar and 187 bipolar depressed inpatients, assigned to rooms with eastern (E) or western (W) windows. RESU...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(00)00149-x
更新日期：2001-02-01 00:00:00
abstract：BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.12.021
更新日期：2010-08-01 00:00:00
abstract：BACKGROUND:Suicide is the second leading cause of death in adolescents. Screening for persons at risk usually includes asking about suicidal ideation, which is considered inappropriate in some societies and situations. To avoid directly addressing suicide, this paper investigates whether the Health Behaviour in School-...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.08.025
更新日期：2020-01-01 00:00:00
abstract：:The ratio of the plasma of total tryptophan to those amino acids that compete with tryptophan during transport into the brain was determined in 60 control subjects and 87 patients suffering from endogenous depression, all females. The plasma ratio in the control subjects showed a significant negative correlation with ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(80)90021-x
更新日期：1980-03-01 00:00:00
abstract：BACKGROUND:Depression is the most common psychiatric disorder in deliberate self-harm (DSH) patients and in those who commit suicide. The aim of this study was to examine the treatment received by DSH patients with depression and their progress following DSH. METHODS:A representative sample of 106 patients with an ICD...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(01)00317-2
更新日期：2002-06-01 00:00:00
abstract：BACKGROUND:The personality trait of Persistence is highly valued by conscientious overachievers, but it has both psychological costs and benefits. The interactions among multiple personality factors influencing the development of mood and anxiety disorders have been confounded in prior clinical samples, but can be dise...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.09.046
更新日期：2012-02-01 00:00:00
abstract：INTRODUCTION:Depression and anxiety are routinely managed by physicians in Family Medicine (FM) or General Internal Medicine (GIM). Because FM requires more behavioral health training than GIM, we sought to determine if prescribing patterns for patients with anxiety, depression, or both differed between FM vs. GIM prov...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.09.056
更新日期：2015-02-01 00:00:00
abstract：:One explanation for the association between mitral valve prolapse (MVP) and panic attacks in clinic populations is that panic attacks represent a set of symptoms caused by mitral prolapse. Since mitral prolapse is often familial, this hypothesis predicts a higher incidence of panic attacks in relatives of persons with...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(82)90042-8
更新日期：1982-06-01 00:00:00
abstract：OBJECTIVE:To explore the alterations and value of brain entropy (BEN) in major depressive disorder (MDD). METHODS:85 MDD patients and 45 matched normal controls were recruited. MDD was diagnosed based on Diagnostic and Statistical Manual of Mental Disorders, 4th ed (DSM-IV). Symptoms of depression were assessed using ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.09.067
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVE:Ethnic, social and cultural factors contribute to axis I comorbid conditions in bipolar disorder (BPD). Korea has strict laws against illicit drugs and a relatively permissive prevailing attitude toward alcohol. The present study aimed to explore the lifetime axis I comorbidity rate in patients with BPD in Ko...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.05.027
更新日期：2014-09-01 00:00:00
abstract：BACKGROUND:Childhood trauma is an important early social risk factor for the development of the major depressive disorder (MDD). Both childhood trauma and depression are associated with dysfunctional attitudes and dysregulation in stress hormones. We aimed to clarify the path from childhood trauma to depression and ide...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.07.023
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Since its introduction in DSM-III, the validity of dysthymia has been debated. Our objective is to further examine the concept of dysthymia in an outpatient sample, and explore whether its constituents can be meaningfully apportioned. METHODS:318 patients attending the Black Dog Institute Depression Clinic ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.05.051
更新日期：2012-12-20 00:00:00
abstract：BACKGROUND:The successful use of serotonin reuptake inhibitors (SRIs) in obsessive-compulsive disorder (OCD) has led to the hypothesis that serotonin plays a pivotal role in the pathogenesis of OCD. The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B an...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.12.011
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVES:It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with the increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. METHODS:The 2001-2002 National Epidemiologic Survey ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.01.029
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:High levels of public spending, rising costs of treatments and scarcity of mental health resources have intensified the need for information on the cost-effectiveness of interventions for depression. There have been few reviews that consider the cost-effectiveness of all treatments for depression together. ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2004.10.003
更新日期：2005-01-01 00:00:00
abstract：:This study tested the use of a subject-own-control, multiple crossover design for evaluating the clinical effects of an established tricyclic antidepressant drug, imipramine. Although significant physiological and cognitive performance effects were demonstrated, only one clinical measure, target symptom change rated b...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/0165-0327(82)90033-7
更新日期：1982-12-01 00:00:00
abstract：BACKGROUND:The development of a full blown depressive episode may be very rapid, taking less than one hour, or be very slow, taking up to months. In a previous study with outpatients it was found that the majority (58%) of depressive episodes within bipolar affective disorders (BD) develop within one week whereas this ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.05.002
更新日期：2012-12-15 00:00:00
abstract：BACKGROUND:Anecdotal reports of mood disorder following infection with common respiratory viruses with neurotropic potential have been in existence since the last century. Nevertheless, systematic studies on the association between these viruses and mood disorders are lacking. METHODS:Influenza A, B and coronavirus an...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.09.029
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:Central banks set economy-wide interest rates to meet exclusively economic objectives. There is a strong link between indebtedness and psychiatric morbidity at the individual level, with interest rates being an important factor determining ability to repay debt. However, no prior research has explored whethe...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.03.003
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Studies have suggested that psychiatric comorbidities have major effects on antidepressant resistance in adult patients with major depressive disorder (MDD). However, the association between psychiatric comorbidities and antidepressant resistance remains unclear in adolescents with MDD. METHODS:A total of 1...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.038
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:In most settings, generalized anxiety disorder (GAD) is highly comorbid with major depressive disorder (MDD). This raises uncertainty about the clinical relevance of GAD as a distinct diagnostic entity. The demonstration of functional impairment attached to GAD, independent of that attributable to MDD, would...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00457-3
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:The overall suicide rate in China has dropped substantially since the 1990s, with patterns changing significantly. This study aims to further explore the latest changes in suicide rates in China. METHODS:Data on gender-age-specific suicide rates for rural and urban residents aged 15 years and above were ret...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.043
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Despite the high prevalence of bipolar spectrum disorders, most instruments currently available for the assessment of depression do not explore symptoms of 'activation' such as anger, irritability, aggressiveness, hostility, and psychomotor activation. METHODS:Two samples of adults with unipolar depression ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00103-9
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Little is known about long-term outcomes of reading problems in childhood on affective symptoms across the life course. The aim of this research was to test longitudinal associations between reading problems in childhood and affective symptoms from adolescence to early old age. METHODS:Data were from the Na...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.12.054
更新日期：2020-12-24 00:00:00
abstract：BACKGROUND:Few prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research. METHOD:We investigated the association between spectral measur...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.02.040
更新日期：2016-05-15 00:00:00
abstract：OBJECTIVE:Although the offspring of parents with major depressive disorder (MDD) are at increased risk to develop disruptive behavior disorders (DBD) in addition to MDD, it remains unclear whether this heightened risk is due to MDD or to comorbid DBD in the parents. METHOD:In a secondary analysis of longitudinal data ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.02.019
更新日期：2008-12-01 00:00:00
abstract：BACKGROUND:Suicide is a major public health problem and depression is among the most important risk factors for suicide. Treatment of depression might prevent suicide. To study this hypothesis further we conducted an ecological study. METHODS:An ecological study using sales data for antidepressants and numbers of suic...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.12.002
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Post-traumatic stress disorder (PTSD) is associated with disruption of the brain network topology; however, little is known about the topological changes and sex effects in PTSD patients following a unique trauma, the loss of an only child, in China. METHODS:Fifty-one lost-only-child parents with PTSD, 93 l...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.07.004
更新日期：2019-10-01 00:00:00
