Abstract：
BACKGROUND:High levels of public spending, rising costs of treatments and scarcity of mental health resources have intensified the need for information on the cost-effectiveness of interventions for depression. There have been few reviews that consider the cost-effectiveness of all treatments for depression together. METHODS:Systematic review of published economic evaluations of interventions for depression to identify where evidence of cost-effectiveness exists and where ambiguity remains. RESULTS:Fifty-eight papers met the criteria and were included in the review. The quality of the evaluations varied greatly. Evidence establishing the cost-effectiveness of interventions for depression is accumulating; selective serotonin reuptake inhibitors (SSRI) and the newer antidepressants venlafaxine, mirtazepine and nefazodone appear cost-effective compared with older drugs. Despite the availability of high quality economic evaluations of psychological therapies compared to usual care, there is limited evidence of their cost-effectiveness particularly when compared directly to pharmacotherapies. Changes to health systems have been found to be cost-effective in some patient groups, but there is no evidence that screening in primary care populations is a cost-effective strategy. LIMITATIONS:Vastly different interventions, outcome measures and cost perspectives meant a meta-analysis of costs and effects was not considered possible. CONCLUSIONS:On the basis of available evidence, it is not possible to identify the most cost-effective strategy for alleviating the symptoms of depression, although the SSRIs and newer antidepressants consistently appear more cost-effective than tricyclic antidepressants in many patient groups. Better quality economic evidence is needed.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Barrett B,Byford S,Knapp Mdoi
10.1016/j.jad.2004.10.003subject
Has Abstractpub_date
2005-01-01 00:00:00pages
1-13issue
1eissn
0165-0327issn
1573-2517pii
S0165-0327(04)00365-9journal_volume
84pub_type
杂志文章,meta分析,评审abstract：BACKGROUND:The functional outcome of Bipolar Disorder (BD) is highly variable. This variability has been attributed to multiple demographic, clinical and cognitive factors. The critical next step is to identify combinations of predictors that can be used to specify prognostic subtypes, thus providing a basis for a stag...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.06.005
更新日期：2013-01-10 00:00:00
abstract：BACKGROUND:Knowledge on the comparative effectiveness of pharmacological treatments to prevent suicide mortality in bipolar disorder is still lacking. METHODS:We studied the risk of suicide mortality during 1996-2012 among all patients who had been hospitalized due to bipolar disorder in Finland (n = 18,018; mean foll...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.016
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:A previous study which compared euthymic Israeli bipolars in a public hospital clinic to US normative data suggested that low Persistence scores on the Tridimensional Personality Questionnaire (TPQ) may be a temperament marker for manic-depressive illness. The current study attempts to replicate that finding...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00075-5
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Borderline personality disorder (BPD) show different course and treatment compared to major depressive disorder (MDD). Early life stress may increase BPD onset; however, resilience may play a protective role against the development of psychopathology. The goal of this study was to compare the early life stre...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.04.119
更新日期：2018-08-15 00:00:00
abstract：BACKGROUND:The function of the hypothalamo-pituitary-adrenal axis (HPA) has been widely investigated in mood disorders based on its role in regulating stress response. Particularly, Magnetic Resonance Imaging (MRI) reports have explored pituitary gland (PG) in both bipolar disorder (BD) and major depressive disorder (M...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2017.03.066
更新日期：2017-08-15 00:00:00
abstract：BACKGROUND:With the possible exception of cyclothymia in artists, there is a paucity of data in the literature on the temperament in different professions. METHODS:For this exploratory study, we sought to generate preliminary data on temperaments among psychiatric outpatients, including physicians (n=41), lawyers (n=3...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2004.08.003
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cor...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.11.046
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:Valproic acid (VPA) is widely used for treating patients with bipolar disorder; however, it has adverse effects on cognitive function. This study investigated the effect of VPA on the risk of dementia in patients with bipolar disorder. METHODS:We analyzed data from Taiwan's Longitudinal Health Insurance Dat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.05.010
更新日期：2016-09-01 00:00:00
abstract：PURPOSE:A number of studies have underlined a 10-20% prevalence of complicated grief (CG) among caregivers of cancer patients. The study aimed at examining the relationship between pre-loss criteria for CG and post-loss diagnosis of CG and at evaluating the validity and factor structure of a predictive tool, the Invent...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.12.023
更新日期：2014-05-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.10.030
更新日期：2016-01-15 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(96)00002-x
更新日期：1996-06-05 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2015.11.047
更新日期：2016-02-01 00:00:00
abstract：BACKGROUND:Postpartum depression (PPD) reportedly affects between 6.5-19% of all new mothers. Identifying those at greatest risk for PPD has implications for prevention, early detection and intervention. While the relationship between extremes of body mass index (BMI) and depression has been frequently studied, the ass...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.063
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Social Anxiety Disorder (SAD) is the second most prevalent psychiatric condition in the US. Because of the inherent nature of SAD, it may cause impairments in workplace functioning, particularly compared to other anxiety disorders that do not necessarily lead to social impairments. In this study, we compared...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.09.024
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The clinically relevant outcomes in treating depression are persistent recovery, relapse, and treatment resistance. METHOD:175 outpatients treated with antidepressants for 6 months were assessed for major depression. Those who had recovered were prospectively monitored for one year to study rates of relapse...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2008.08.002
更新日期：2009-04-01 00:00:00
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journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2018.11.087
更新日期：2019-02-15 00:00:00
abstract：BACKGROUND:Recent research has shown that a polymorphism in the dopamine D2 receptor gene (DRD2) moderates the association between stressful life events and depression. The present study builds off this literature and examines whether DRD2 moderates the effect of violent victimization on depression. Furthermore, the cu...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.03.027
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Deficits in executive functioning (EF) are implicated in neurobiological and cognitive-processing theories of depression. EF deficits are also associated with Attention-deficit/hyperactivity disorder (ADHD) in adults, who are also at increased risk for depressive disorders. Given debate about the ecological ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.05.064
更新日期：2013-02-20 00:00:00
abstract：:Assortative mating was determined in 170 spouses of patients with major affective illness (bipolar and unipolar). An increase in affective disorders was found in both wives of affected men and husbands of affected women. The data suggest that assortative mating is present in the familial transmission of affective diso...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(81)90041-0
更新日期：1981-06-01 00:00:00
abstract：BACKGROUND:Affective symptoms in Alzheimer's disease (AD) can be rated with both informant- and self-ratings. Information from these two modalities may not converge. We estimated network structures of affective symptoms in AD with both rating modalities and assessed the longitudinal stability of the networks. METHODS:...
journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.02.092
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Depressive disorders are among the most pressing public health challenges worldwide. Yet, not enough is known about their long-term outcomes. This study examines the course and predictors of different outcomes of depressive disorders in an eleven-year follow-up of a general population sample. METHODS:In a n...
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pub_type： 杂志文章
doi：10.1016/j.jad.2015.10.043
更新日期：2016-01-15 00:00:00
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journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.06.028
更新日期：2016-11-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.04.027
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Physical exercise has been extensively researched as a therapeutic option for treatment of major depression. METHODS:In a randomized controlled trial, we analyze the effects of aerobic physical exercise as an add-on strategy for treatment of severe depressed inpatients. The exercise has a "Dose" of 16.5 kca...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2011.04.030
更新日期：2011-10-01 00:00:00
abstract：:The paper reviews briefly and comments in detail on selected events in the history of lithium treatment. The events include Cade's discovery of lithium's antimanic action, the discovery and establishment of its prophylactic action, the ensuing debate, amelioration and prevention of side effects and risks, use during p...
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pub_type： 历史文章,杂志文章,评审
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更新日期：2001-12-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.10.047
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Research showed that the perception of unmet needs may differ between patients, caregivers and professionals. Lacking agreement with regard to unmet needs between raters involved may have a negative impact on treatment of late-life depression. METHODS:As part of the multicenter German study "Late-life depre...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.07.001
更新日期：2016-11-15 00:00:00
abstract：BACKGROUND:Personality assessment may allow reliable measurement of risk of mood disorders. METHODS:A group of adults (804) representative of the general population were assessed by questionnaire. Personality types were measured by the Temperament and Character Inventory (TCI). RESULTS:Specific TCI configurations def...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00153-0
更新日期：1998-10-01 00:00:00
