Abstract：
BACKGROUND:The clinically relevant outcomes in treating depression are persistent recovery, relapse, and treatment resistance. METHOD:175 outpatients treated with antidepressants for 6 months were assessed for major depression. Those who had recovered were prospectively monitored for one year to study rates of relapse (at least two weeks of major depression). Those who were depressed at 6 months were monitored for rates of recovery (at least 8 weeks of no major depression). RESULTS:94% of the sample was monitored for one year. Of the 123 patients who were not depressed at 6 months 57 (46%) relapsed. Patients who relapsed were more likely to have a history of recurrent depression, to have residual depressive symptoms, to have a less sustained response to initial treatment, to have avoidant personality disorder symptoms, schizotypal personality disorder symptoms, higher harm avoidance (HA) scores and lower self directedness (SD) scores. Of the 38 patients who were depressed at 6 months 13 (34%) recovered. There were no patient characteristics associated with recovery. LIMITATIONS:The findings apply to moderately depressed outpatients. There was no placebo control. CONCLUSION:Most patients with depression will recover but many become unwell again within a year. Clinically long term monitoring and sustained efforts to treat patients with major depression seem warranted.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Mulder RT,Frampton CM,Luty SE,Joyce PRdoi
10.1016/j.jad.2008.08.002subject
Has Abstractpub_date
2009-04-01 00:00:00pages
263-70issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(08)00325-Xjournal_volume
114pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Major depression (MD) results from a complex synergy between genetic and environmental factors. The aim of this study is to analyze the interaction of tryptophan hydroxylase 2 gene (TPH2) variation and negative life events in the pathogenesis of MD. Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs1...
journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:The last decade has seen the burgeoning publication of male-specific depression rating scales designed to assess externalising depression symptoms (e.g., substance use, risk-taking, and aggression). These symptoms are theorised to reflect the behavioural manifestation of depression amongst men who rigidly co...
journal_title：Journal of affective disorders
pub_type： 杂志文章
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abstract：BACKGROUND:The aim of this study was to investigate whether a different pattern of HPA axis activity is found between children with social phobia (SP) and healthy control children. METHODS:A total of 50 prepubertal subjects (25 children with SP and 25 healthy control subjects) were studied. The effects of stress were ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
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abstract：BACKGROUND:The β2 subunit of the voltage-gated l-type calcium channel gene(CACNB2) rs11013860 polymorphism is a putative genetic susceptibility marker for bipolar disorder (BD). However, the neural effects of CACNB2 rs11013860 in BD are largely unknown. METHODS:Forty-six bipolar patients with first-episode mania and e...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.02.007
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
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doi：10.1016/j.jad.2014.08.009
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.03.042
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2015.11.043
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
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更新日期：2015-11-15 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.05.002
更新日期：2008-01-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1016/j.jad.2005.12.045
更新日期：2006-05-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Journal of affective disorders
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
pub_type： 评论,信件
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2017-03-15 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2010-12-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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journal_title：Journal of affective disorders
pub_type： 杂志文章
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更新日期：2013-04-25 00:00:00
abstract：INTRODUCTION:Bipolar disorder (BD) often starts in childhood or adolescence. There is considerable scepticism outside the United States over the validity, stability and prevalence of BD in children and adolescents. Persistence of course lends support to the validity of a diagnosis. OBJECTIVES:To describe the longitudi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.01.013
更新日期：2011-07-01 00:00:00
