Abstract：
BACKGROUND:Psychiatric comorbidity of autism spectrum disorder (ASD) has not been well examined. METHODS:Mood disorders in 44 consecutive outpatients with high-functioning ASD were examined at a university hospital according to DSM-IV. Inclusion criteria were an IQ of 70 or higher on the Wechsler Intelligence Scale and age of 12 years or over. RESULTS:Sixteen patients (36.4%) were diagnosed with mood disorder. Of these 16 patients, four were diagnosed as having major depressive disorder, two patients as bipolar I disorder, six patients as bipolar II disorder, and four patients as bipolar disorder not otherwise specified. Bipolar disorder accounted for 75% of cases. Twelve patients had Asperger disorder and four patients had pervasive developmental disorder not otherwise specified. None of the patients had autistic disorder. LIMITATIONS:The sample size was small. We could not use Autism Diagnostic Interview - Revised. Referral bias could not be avoided in this study. CONCLUSIONS:The major comorbid mood disorder in patients with high-functioning ASD is bipolar disorder and not major depressive disorder. The autistic spectrum may share common vulnerability genes with the bipolar spectrum.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Munesue T,Ono Y,Mutoh K,Shimoda K,Nakatani H,Kikuchi Mdoi
10.1016/j.jad.2008.02.015subject
Has Abstractpub_date
2008-12-01 00:00:00pages
170-5issue
2-3eissn
0165-0327issn
1573-2517pii
S0165-0327(08)00098-0journal_volume
111pub_type
杂志文章abstract：BACKGROUND:The validity of a sub-classification of affective psychosis according to the mood congruence of psychotic features has been questioned in the literature. While some authors have found a correlation between such symptoms and outcome, their predictive value was rather limited in these studies. METHOD:Prospect...
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90025-f
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