Reliability and validity of the Hospital Anxiety and Depression Scale and the Beck Depression Inventory (Full and FastScreen scales) in detecting depression in persons with hepatitis C.


BACKGROUND:We examined the performance the Beck Depression Inventory (BDI) and its short form (BDI-FS) and the Hospital Anxiety and Depression Scale depression (HADS-D) and anxiety (HADS-A) subscales in detecting depression in a group of patients with hepatitis C. METHODS:SCID-CV was used to establish DSM-IV diagnosis. Sensitivity, specificity, positive and negative predictive values were used to assess test performance and Cohen's Kappa to measure agreement with DSM diagnosis. RESULTS:Twenty-five of 88 participants had a DSM-IV depressive diagnosis. There was considerable non-overlap between 'caseness' on the BDI and HADS (Kappa=0.44). The HADS depression subscale had poor sensitivity (52%) and poor agreement with clinical diagnosis (Kappa=0.35). The full BDI had a sensitivity of 88% and a Kappa of 0.54 against a sensitivity of 84% and Kappa of 0.42 for the short form. The HADS anxiety subscale predicted depression as well as the depression subscale (sensitivity 88%, Kappa 0.47). CONCLUSIONS:Neither the BDI nor the HADS agrees well with the clinical diagnosis of depressive disorder, nor do they agree well with one another. The anxiety subscale of the HADS appears to measure depression at least as well as the depressive subscale.


J Affect Disord


Golden J,Conroy RM,O'Dwyer AM




Has Abstract


2007-06-01 00:00:00














  • The risk of Bipolar Disorders in Multiple Sclerosis.

    abstract:BACKGROUND:The aim was to determine the risk of Mood Disorders (MD), particularly Bipolar Disorders (BD), in Multiple Sclerosis (MS) using standardized psychiatric diagnostic tools. METHODS:Case-control study. CASES:201 consecutive-patients with MS. CONTROLS:804 sex- and age-matched subjects without MS, randomly sel...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Carta MG,Moro MF,Lorefice L,Trincas G,Cocco E,Del Giudice E,Fenu G,Colom F,Marrosu MG

    更新日期:2014-02-01 00:00:00

  • Personality disorders and suicide attempts in unipolar and bipolar mood disorders.

    abstract:BACKGROUND:Comorbid personality disorders may predispose patients with mood disorders to suicide attempts (SAs), but factors mediating this effect are not well known. METHODS:Altogether 597 patients from three prospective cohort studies (Vantaa Depression Study, Jorvi Bipolar Study, and Vantaa Primary Care Depression ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Jylhä P,Rosenström T,Mantere O,Suominen K,Melartin T,Vuorilehto M,Holma M,Riihimäki K,Oquendo MA,Keltikangas-Järvinen L,Isometsä ET

    更新日期:2016-01-15 00:00:00

  • Proton magnetic resonance spectroscopic imaging of gray and white matter in bipolar-I and schizophrenia.

    abstract:BACKGROUND:Glutamine plus glutamate (Glx), as well as N-acetylaspartate compounds, (NAAc), a marker of neuronal viability, are quantified with proton magnetic resonance spectroscopy (1H-MRS) and have been reported altered in psychotic disorders. However, few studies have compared these neurometabolites in bipolar disor...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Bustillo JR,Jones T,Qualls C,Chavez L,Lin D,Lenroot RK,Gasparovic C

    更新日期:2019-03-01 00:00:00

  • Subcortical structural volumes in recently remitted first episode mania.

    abstract:BACKGROUND:Magnetic resonance imaging (MRI) studies have yielded inconsistent findings with regard to subcortical volumetric abnormalities in patients with bipolar I disorder. Duration of illness and long term medication intake could have confounded the findings. METHOD:Volumes of nine subcortical structures were comp...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Arumugham SS,Torres IJ,Lang DJ,Su W,Lam RW,Honer WG,Yatham LN

    更新日期:2017-11-01 00:00:00

  • Comorbidity of PTSD and depression following myocardial infarction.

    abstract:BACKGROUND:This study examines comorbidity of posttraumatic stress disorder (PTSD) and depression following myocardial infarction (MI). It has two aims: (a) to examine whether this comorbidity is predicted by the objective severity of the MI and the patients' initial appraisal and stress responses; and (b) to determine...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Ginzburg K

    更新日期:2006-08-01 00:00:00

  • Economic costs of full-blown and subthreshold panic disorder.

    abstract:BACKGROUND:Data on the societal costs of mental disorders are necessary to inform health policies. METHODS:This study assessed the costs of panic disorder and subthreshold panic disorder, compared these with costs of other mental disorders, and assessed the effects of (psychiatric and somatic) comorbidity and agorapho...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Batelaan N,Smit F,de Graaf R,van Balkom A,Vollebergh W,Beekman A

    更新日期:2007-12-01 00:00:00

  • Association of marital status with the incidence of suicide: a population-based Cohort Study in Japan (Miyagi cohort study).

    abstract:BACKGROUND:Marital status is one of the most frequently replicated predictors of suicide. The purpose of this study was to examine the effect of marital status on the risk of suicide by gender, using a large population-based cohort in Japan. METHODS:The Miyagi cohort study was a population-based, prospective cohort st...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Fukuchi N,Kakizaki M,Sugawara Y,Tanji F,Watanabe I,Fukao A,Tsuji I

    更新日期:2013-09-25 00:00:00

  • Prevalence and correlates of depression among HIV-infected and -affected older people in rural South Africa.

    abstract:BACKGROUND:Little is known about depression in older people in sub-Saharan Africa, the associated impact of HIV, and the influence on health perceptions. OBJECTIVES:Examine the prevalence and correlates of depression; explore the relationship between depression and health perceptions in HIV-infected and -affected olde...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Nyirenda M,Chatterji S,Rochat T,Mutevedzi P,Newell ML

    更新日期:2013-10-01 00:00:00

  • Single-nucleotide polymorphism in the human TIA1 gene interacts with stressful life events to predict the development of pathological anxiety symptoms in a Swedish population.

    abstract:BACKGROUND:The TIA1 gene encodes a prion-related RNA-binding protein that regulates stress-dependent synaptic plasticity and fear memory in mice. It is unknown whether genetic variation in human TIA1 is associated with differences in stress- and fear-related behavior in people. METHODS:A longitudinal, population-based...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rayman JB,Melas PA,Schalling M,Forsell Y,Kandel ER,Lavebratt C

    更新日期:2020-01-01 00:00:00

  • Excess mortality of bipolar and unipolar manic-depressive patients.

    abstract::To compare mortality in bipolar and unipolar manic-depressive patients, 2168 manic-depressive first admissions reported to the Danish Psychiatric Central Register were divided into a bipolar group (19%), i.e., patients with at least one admission for mania during an average observation period of six years, and a unipo...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Weeke A,Vaeth M

    更新日期:1986-11-01 00:00:00

  • Fluoxetine in tricyclic refractory major depressive disorder.

    abstract::Data regarding open-label treatment with fluoxetine following failure to respond to tricyclic antidepressants (TCAs) or intolerance of TCA side effects, suggest a response rate between 51.4% and 62.1%, depending on the definition of TCA refractoriness employed. Double-blind study of this issue would extend these findi...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章


    authors: Beasley CM Jr,Sayler ME,Cunningham GE,Weiss AM,Masica DN

    更新日期:1990-11-01 00:00:00

  • Different profile of substance abuse in relation to predominant polarity in bipolar disorder: The Vitoria long-term follow-up study.

    abstract:BACKGROUND:There is a need for comparisons of long-term outcomes in bipolar disorder patients with predominantly manic symptoms vs. predominantly depressive symptoms, especially the course of comorbid alcohol/substance abuse. METHOD:A naturalistic sample of bipolar I patients (n=120) was followed prospectively for up ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: González-Pinto A,Alberich S,Barbeito S,Alonso M,Vieta E,Martínez-Arán A,Saenz M,López P

    更新日期:2010-08-01 00:00:00

  • Cognitive styles and future depressed mood in early adulthood: the importance of global attributions.

    abstract:BACKGROUND:Cognitive theories of depression suggest that beliefs of low self-worth and the tendency to attribute negative events to causes that are global (widespread rather than specific) and stable (will persist rather than change in the future) are associated with the development of depressed mood. Such theories are...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Pearson RM,Heron J,Button K,Bentall RP,Fernyhough C,Mahedy L,Bowes L,Lewis G

    更新日期:2015-01-15 00:00:00

  • The association between body mass index and postpartum depression: A population-based study.

    abstract:BACKGROUND:Postpartum depression (PPD) reportedly affects between 6.5-19% of all new mothers. Identifying those at greatest risk for PPD has implications for prevention, early detection and intervention. While the relationship between extremes of body mass index (BMI) and depression has been frequently studied, the ass...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Silverman ME,Smith L,Lichtenstein P,Reichenberg A,Sandin S

    更新日期:2018-11-01 00:00:00

  • Manifestations of overarousal account for the association between cognitive anxiety sensitivity and suicidal ideation.

    abstract:BACKGROUND:Recent evidence suggests an association between cognitive anxiety sensitivity and suicidal ideation. Cognitive anxiety sensitivity has also been implicated as a precursor to various forms of overarousal. These manifestations of overarousal (i.e., agitation, insomnia, nightmares, and anger) may account for th...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Rogers ML,Tucker RP,Law KC,Michaels MS,Anestis MD,Joiner TE

    更新日期:2016-03-01 00:00:00

  • The mental health of frontline and non-frontline medical workers during the coronavirus disease 2019 (COVID-19) outbreak in China: A case-control study.

    abstract:BACKGROUND AND OBJECTIVE:Coronavirus disease 2019 (COVID-19) is a new infectious disease with high transmissibility and morbidity. It has caused substantial mental distress to medical professionals. We aimed to compare the psychological impact of the COVID-19 outbreak between frontline and non-frontline medical workers...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Cai Q,Feng H,Huang J,Wang M,Wang Q,Lu X,Xie Y,Wang X,Liu Z,Hou B,Ouyang K,Pan J,Li Q,Fu B,Deng Y,Liu Y

    更新日期:2020-10-01 00:00:00

  • Modifying a negative interpretation bias for ambiguous social scenarios that depict the risk of rejection in women with anorexia nervosa.

    abstract:BACKGROUND:A heightened sensitivity to social rejection might contribute towards the interpersonal difficulties and symptoms that characterise Anorexia Nervosa (AN). This paper examines the effect of Cognitive Bias Modification for Interpretation biases (CBM-I) training on a negative interpretation bias for ambiguous s...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Turton R,Cardi V,Treasure J,Hirsch CR

    更新日期:2018-02-01 00:00:00

  • Creativity and executive function across manic, mixed and depressive episodes in bipolar I disorder.

    abstract:INTRODUCTION:Creativity is a complex construct involving affective and cognitive components. Bipolar Disorder (BD) has been associated with creativity and is characterized by a wide range of affective and cognitive symptoms. Although studies of creativity in BD have tended to focus on creativity as a trait variable in ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Soeiro-de-Souza MG,Dias VV,Bio DS,Post RM,Moreno RA

    更新日期:2011-12-01 00:00:00

  • Alteration of cardiac autonomic functions in patients with major depression: a study using heart rate variability measures.

    abstract:BACKGROUND:Depression is associated with greater cardiac morbidity and mortality. One of the contributory factors for this may be altered cardiac autonomic activity in depression. However, cardiac autonomic involvement in depression remains controversial because of methodological issues. In this study, alteration of ca...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Udupa K,Sathyaprabha TN,Thirthalli J,Kishore KR,Lavekar GS,Raju TR,Gangadhar BN

    更新日期:2007-06-01 00:00:00

  • Core belief content examined in a large sample of patients using online cognitive behaviour therapy.

    abstract:BACKGROUND:Computerised cognitive behavioural therapy provides a unique opportunity to collect and analyse data regarding the idiosyncratic content of people's core beliefs about the self, others and the world. METHODS:'Beating the Blues' users recorded a core belief derived through the downward arrow technique. Core ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Millings A,Carnelley KB

    更新日期:2015-11-01 00:00:00

  • Neuroendocrine studies in affective disorders. Part 1. Plasma prolactin response to thyrotropin-releasing hormone in affective disorders: effect of ECT.

    abstract::The plasma prolactin response to thyrotropin-releasing hormone, which is thought to be mediated by central 5-HT mechanisms, has been studied in patients with affective disorders. There was no difference between depressive patients (taken as a whole), bipolar patients undergoing a manic phase and controls in the prolac...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Coppen A,Rao VA,Bishop M,Abou-Saleh MT,Wood K

    更新日期:1980-12-01 00:00:00

  • Early experience and depressive disorders: human and non-human primate studies.

    abstract::This paper reviews evidence from both human and non-human primate studies concerning the role of early adverse experiences in the onset and course of adult depressive disorders. Despite accumulating evidence that stressful life events can play a major role in precipitating the onset of depressive episodes in humans, t...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审


    authors: Gilmer WS,McKinney WT

    更新日期:2003-07-01 00:00:00

  • Interaction of tryptophan hydroxylase 2 gene and life events in susceptibility to major depression in a Chinese Han population.

    abstract:BACKGROUND:Major depression (MD) results from a complex synergy between genetic and environmental factors. The aim of this study is to analyze the interaction of tryptophan hydroxylase 2 gene (TPH2) variation and negative life events in the pathogenesis of MD. Three TPH2 polymorphisms, -703G/T (rs4570625), -473T/A (rs1...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Ma J,Xiao H,Yang Y,Cao D,Wang L,Yang X,Qiu X,Qiao Z,Song J,Liu Y,Wang P,Zhou J,Zhu X

    更新日期:2015-12-01 00:00:00

  • Sleep matters: sleep functioning and course of illness in bipolar disorder.

    abstract:BACKGROUND:Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder. METHODS:The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Gruber J,Miklowitz DJ,Harvey AG,Frank E,Kupfer D,Thase ME,Sachs GS,Ketter TA

    更新日期:2011-11-01 00:00:00

  • Maternal depression trajectories and child executive function over 9 years.

    abstract:BACKGROUND:The present study aimed to assess the relationship between maternal depression trajectories from pregnancy to 2 years after childbirth and childhood behavioral problems and executive function at 9 years. METHODS:Data of mother-child pairs (N = 1191) extracted from the Panel Study on Korean Children (a cohor...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Oh Y,Joung YS,Baek JH,Yoo N

    更新日期:2020-11-01 00:00:00

  • Depression and executive functioning deficits predict poor occupational functioning in a large longitudinal sample with bipolar disorder.

    abstract:BACKGROUND:Bipolar Disorder (BD) is characterized by impairments in psychosocial functioning with occupational disability being one of the most significant. Depression and neurocognitive deficits are features of BD most commonly associated with poor occupational functioning (OF). Few studies have examined these feature...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: O'Donnell LA,Deldin PJ,Grogan-Kaylor A,McInnis MG,Weintraub J,Ryan KA,Himle JA

    更新日期:2017-06-01 00:00:00

  • Assessing the role of the amygdala in fear of pain: Neural activation under threat of shock.

    abstract:INTRODUCTION:The DSM-5 explicitly states that the neural system model of specific phobia is centered on the amygdala. However, this hypothesis is predominantly supported by human studies on animal phobia, whereas visual cuing of other specific phobias, such as dental fear, do not consistently show amygdala activation. ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Sambuco N,Costa VD,Lang PJ,Bradley MM

    更新日期:2020-11-01 00:00:00

  • Measuring treatment response in psychotic depression: the Psychotic Depression Assessment Scale (PDAS) takes both depressive and psychotic symptoms into account.

    abstract:BACKGROUND:There is no established psychometric instrument dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to investigate whether a new composite rating scale, the Psychotic Depression Assessment Scale (PDAS), covering both the psychotic and the depressive domains of PD,...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验


    authors: Østergaard SD,Meyers BS,Flint AJ,Mulsant BH,Whyte EM,Ulbricht CM,Bech P,Rothschild AJ,STOP-PD Study Group.

    更新日期:2014-05-01 00:00:00

  • Resting electroencephalographic correlates of the clinical response to repetitive transcranial magnetic stimulation: A preliminary comparison between unipolar and bipolar depression.

    abstract:BACKGROUND:Major depressive disorder (MDD) and bipolar disorder (BP) are two different types of mood disorders, sometimes difficult to distinguish from their depressive symptoms, and for which repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex (DLPFC) has been proposed to treat re...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章


    authors: Woźniak-Kwaśniewska A,Szekely D,Harquel S,Bougerol T,David O

    更新日期:2015-09-01 00:00:00

  • Subsyndromal depression in adolescents after a brief psychotherapy trial: course and outcome.

    abstract:INTRODUCTION:Subsyndromal depression has been associated with an increased risk of the development of major depressive disorder (MDD). Since treatment trials of adolescent MDD often result in subsyndromal depression as the outcome, the long-term course of these youth would be useful to understand. METHODS:107 adolesce...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章


    authors: Brent DA,Birmaher B,Kolko D,Baugher M,Bridge J

    更新日期:2001-03-01 00:00:00