Abstract：
:The DSM-III divides anxiety disorders into two broad categories, Phobic Disorders and Anxiety States. Anxiety states characterised by panic attacks have been separated from generalised anxiety disorders. While this classification may not be generally accepted it is of heuristic value. Delineation of panic disorder as a distinct diagnostic entity has led to renewed efforts to identify a biological cause for the sudden severe somatic and psychological symptoms experienced by these patients. A review of evidence for the involvement of the major neurotransmitter systems is presented. Systematic investigations in DSM-III defined groups of patients are only beginning to be reported. It is difficult as yet to draw any definite conclusions, but some tentative evidence for abnormalities of the noradrenergic system and the GABA-benzodiazepine chloride ionophore receptor complex are emerging. The reliable induction of panic attacks by chemical agents provides the promise of a greater understanding of the possible biological mechanisms involved in this anxiety disorder.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Judd FK,Burrows GD,Norman TRdoi
10.1016/0165-0327(85)90058-8subject
Has Abstractpub_date
1985-11-01 00:00:00pages
271-84issue
3eissn
0165-0327issn
1573-2517pii
0165-0327(85)90058-8journal_volume
9pub_type
杂志文章abstract：BACKGROUND:Accumulating evidence indicates a high prevalence rate of metabolic disturbance in bipolar disorder (BP) patients. However, the prevalence across BP subtypes has been investigated to a lesser degree. In the current study, we surveyed the prevalence of metabolic syndrome among drug-naïve bipolar II patients. ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.08.042
更新日期：2013-03-20 00:00:00
abstract：BACKGROUND:While factors associated with mixed states have been extensively studied, data are scant regarding the clinical heterogeneity of mixed states. The EMBLEM study was a prospective, observational study on patients with manic and mixed states. We describe and compare baseline characteristics and 24-month clinica...
journal_title：Journal of affective disorders
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更新日期：2013-04-25 00:00:00
abstract：BACKGROUND:Panic disorder (PD) occurs at high rates in bipolar disorder and more commonly than in unipolar depression. Reports of PD onset during hypomania and depressive mania (i.e., mixed states) raise questions about whether the affective disturbances of bipolar disorder play a specific role in the exacerbation or o...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.02.004
更新日期：2005-07-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.08.017
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Psychosocial assessment of self-harm patients by mental health service staff is an important aspect of their care. Nevertheless, in England around half of those attending a general hospital following a self-harm episode do not receive such an assessment. We have investigated the reasons for this and the char...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.08.011
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Various studies showed that personality traits and resilience might have impacts on depressive symptoms, separately. However, the relationships among personality traits, resilience and depressive symptoms are still undefined. Thus, this study tried to explore the potential effect of resilience on the associa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.102
更新日期：2020-03-15 00:00:00
abstract：OBJECTIVE:Somatic symptoms have been suggested to negatively affect the course of major depressive disorder (MDD). Mechanisms behind this association, however, remain elusive. This study examines the impact of somatic symptoms on MDD prognosis and aims to determine whether this effect can be explained by psychiatric ch...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.06.030
更新日期：2016-11-15 00:00:00
abstract：BACKGROUND:Though the social functioning of most depressed outpatients improves with effective treatment, a subgroup may remain impaired after recovering from depression. The purpose of this study was to identify predictors of residual social impairment among patients who recovered from depression. METHODS:These data ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00200-6
更新日期：1999-10-01 00:00:00
abstract：BACKGROUND:Bipolar disorder (BPD) is a disabling disease with high morbidity rates. An international (Spain, France) comparative study about hospitalizations and in-patient care costs associated with BPD I was performed. Centers were included if they had access to a database of computerized patient charts exhaustively ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.05.010
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Diminished physical and mental health-related quality of life (HRQoL) is a common consequence of road traffic crash (RTC) injury. This study aimed to (a) determine the probable recovery trajectories in physical and mental HRQoL; (b) examine the impact of posttraumatic stress disorder (PTSD) on HRQoL scores w...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.02.031
更新日期：2017-05-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.05.060
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:Electroconvulsive therapy (ECT) is a highly effective treatment for depression but its use is limited by the risk of cognitive side effects. This study explored the potential of a novel approach, ultrabrief pulsewidth (0.3 ms) right unilateral (RUL-UB) ECT, to minimise cognitive effects while preserving effi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.06.012
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:Bipolar disorder (BD) is burdensome for patients and healthcare systems. This study evaluated changes in concomitant medication patterns, healthcare utilization, and costs after the initiation of risperidone long-acting injection (RLAI) treatment among BD patients. METHOD:287 BD patients receiving regular RL...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.04.074
更新日期：2017-08-15 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.04.024
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Anger attacks, characterized by sudden episodes of intense anger with autonomic arousal, have been described in patients with major depressive disorder (MDD). This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression. METHODS:Using the questionnaire ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00451-2
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:Studying the phenotypic manifestations of increased genetic liability for Bipolar Disorder (BD) can increase understanding of this disorder. AIMS:We assessed whether genetic risk for BD was associated with childhood psychopathology and features of hypomania in young adulthood within a large population-based...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.12.091
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Anxiety is a common mental health problem in youth. The current study aimed to test the effectiveness of an online self-directed anxiety prevention program in a school-based sample and to compare two methods of implementing an anxiety program in schools. METHODS:A three-arm cluster stratified randomised con...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2016.02.049
更新日期：2016-05-15 00:00:00
abstract：:A possible role for somatostatin in affective disorders is suggested by its low concentration in cerebrospinal fluid of patients with depression. Therefore, we studied the regional effects of antidepressant drugs and antimanic agents on somatostatin concentrations in rat brain. Repeated, but not acute, administration ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(92)90078-k
更新日期：1992-08-01 00:00:00
abstract：BACKGROUND:Results from short-term treatment studies have demonstrated the efficacy of antidepressant medications for outpatients with early-onset chronic depression. However, scant data exists regarding the long-term outcome of these patients treated for this disorder. METHODS:The author conducted a one-year naturali...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0165-0327(98)00040-8
更新日期：1999-07-01 00:00:00
abstract：BACKGROUND:Seasonality of suicide has been noted in several studies. A spring peak of suicide was observed, and associations between various climatic parameters and suicide have been suggested. This study sets out to verify seasonal patterns of suicide rates and to explore the association with climate in Taiwan. METHO...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.01.026
更新日期：2006-06-01 00:00:00
abstract：:Linkage between stuttering and manic-depression has been postulated to account for the reported association between these conditions, in three large pedigrees. This finding permits a novel and potentially more productive sampling strategy to be used in future linkage studies. ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90043-j
更新日期：1993-06-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jad.2017.09.046
更新日期：2018-01-15 00:00:00
abstract：BACKGROUND:Agricultural pesticide poisoning is a major contributor to the global burden of suicide. Over the last decade there has been a marked decrease in the incidence of suicide worldwide. It is unclear whether pesticide poisoning still plays a significant role in the global incidence of suicide. METHODS:WHO metho...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2017.05.002
更新日期：2017-09-01 00:00:00
abstract：BACKGROUNDS:Panic disorder is a highly prevalent psychiatric disorder that substantially impairs quality of life and psychosocial function. Panic disorder arises from neurobiological substrates and developmental factors that distinguish it from other anxiety disorders. Differential diagnosis between panic disorder and ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.09.027
更新日期：2021-01-01 00:00:00
abstract：:Eight inpatients with Major Depression were treated with metyrapone and hydrocortisone in a balanced order placebo-controlled single-blind cross-over study. The hydrocortisone dose (30 mg daily) was a physiological replacement dose and the metyrapone dose was titrated against plasma cortisol in order to keep cortisol ...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-0327(94)00082-k
更新日期：1995-02-21 00:00:00
abstract：BACKGROUND:Depression is common in nursing-home patients and is often of chronic nature. AIMS:To examine the prevalence, incidence and the persistence rates of clinically significant depressive symptoms, and their risk factors among nursing-home patients. DESIGN:A 12 months follow-up study. METHODS:A sample of 902 r...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.04.028
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:To examine whether racial/ethnic differences in receipt of MDD treatment could be explained by the specialty of provider diagnosing the adolescent. METHOD:Adolescents (10-20 years-old) with ≥2 MDD diagnoses were identified using 2005-2007 Medicaid data from Texas. Patients were categorized based on the type...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.04.045
更新日期：2018-08-01 00:00:00
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journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2018.04.016
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Genetic factors are important in the development of posttraumatic stress disorder (PTSD) following exposure to traumatic events. However, the molecular genetic underpinnings of this disorder remain largely unresolved. The present study investigated the association between ADCYAP1R1 rs2267735 genotype and PTS...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.01.010
更新日期：2013-08-15 00:00:00
abstract：BACKGROUND:There is a discrepancy in the frequency of non-lethal and lethal suicidal behavior. Given the extensive training in firearms within the military and prior research indicating that military personnel exhibit elevated mean levels of the acquired capability, we hypothesized that the ratio between non-lethal and...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.11.045
更新日期：2013-05-15 00:00:00
