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Repeated administration of antidepressant drugs reduces regional somatostatin concentrations in rat brain.

Abstract：

:A possible role for somatostatin in affective disorders is suggested by its low concentration in cerebrospinal fluid of patients with depression. Therefore, we studied the regional effects of antidepressant drugs and antimanic agents on somatostatin concentrations in rat brain. Repeated, but not acute, administration of clomipramine, a specific serotonin uptake inhibitor, caused a highly significant, widespread reduction in somatostatin levels. Somatostatin content was similarly reduced in the hypothalamus, and midbrain and thalamus following repeated administration of zimelidine, another specific serotonin uptake inhibitor. Repeated administration of either imipramine, maprotiline, mianserin, carbamazepine or zotepine were without effect on somatostatin levels. These results suggest that somatostatin in the brain might be involved in therapeutic effects of some of antidepressant drugs.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Kakigi T,Maeda K,Kaneda H,Chihara K

doi

10.1016/0165-0327(92)90078-k

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

215-20

issue

4

eissn

0165-0327

issn

1573-2517

pii

0165-0327(92)90078-K

journal_volume

25

pub_type

杂志文章

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