Abstract：
BACKGROUND:Impulsivity is a common feature shared by bipolar disorder (BD) and substance use disorder (SUD). SUD and recurrent mood episodes are considered to be risk factors for poor outcome in BD. However, the association between impulsivity, illness chronicity and SUD in BD remains unexplored. METHODS:103 BD patients with and without a lifetime history of SUD (36.82±11.34 years, 40 males) were recruited. Participants completed the SCID interview and were administered measures of impulsivity including the Barratt Impulsivity Scale (BIS) and selected tests of the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hierarchical regression analyses explored the relationship between illness chronicity, SUD, and impulsivity. RESULTS:Variance in the BIS, number of false alarms on the Rapid Visual Processing task and other impulsivity indicators of the Cambridge Gambling Task (CGT) was not explained by the chosen variables. Only an increased number of commission errors in the negative condition of the Affective Go/No Go task was significantly associated with illness chronicity. Furthermore there was a trend suggesting a relationship between a lifetime history of SUD and increased propensity to risk-taking during the CGT. LIMITATIONS:Potential limitations include medication and patients׳ remission status from SUD. CONCLUSIONS:Contrary to our expectations impulsivity was generally not predicted by indicators of illness chronicity or SUD. While impulsivity could still be a marker of BD that is present before the onset of the disorder, the link between the number of mood episodes and specific indicators of impulsivity may be related to mechanisms of neuroprogression.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Bauer IE,Meyer TD,Sanches M,Zunta-Soares G,Soares JCdoi
10.1016/j.jad.2015.03.010subject
Has Abstractpub_date
2015-07-01 00:00:00pages
142-7eissn
0165-0327issn
1573-2517pii
S0165-0327(15)00139-1journal_volume
179pub_type
杂志文章abstract：BACKGROUND:The vascular endothelial growth factor (VEGF) signaling, which modulates angiogenesis and neurogenesis within the neurovascular unit, might play an important role in the neuro-endocrine-immune (NEI) stress-adaptation system. Recent evidence suggests that VEGF is involved in the pathophysiology of a number of...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.06.055
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Serotonin transporter-linked polymorphic region (5-HTTLPR) variants have been extensively studied in psychiatric disorders. Although gender effects have been reported, they have not been comprehensively reviewed. The aim of our study was to summarize literature findings on 5-HTTLPR and gender differences in ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2015.09.027
更新日期：2016-01-15 00:00:00
abstract：BACKGROUND:Depression is associated with greater cardiac morbidity and mortality. One of the contributory factors for this may be altered cardiac autonomic activity in depression. However, cardiac autonomic involvement in depression remains controversial because of methodological issues. In this study, alteration of ca...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.10.007
更新日期：2007-06-01 00:00:00
abstract：BACKGROUND:Default mode network (DMN) has been widely reported to be altered in bipolar disorder during major depressive episode (BDD). Recent studies supported the idea that DMN is not an unitary system, but composed of smaller and distinct functional subsystems. The current study aimed to investigate the abnormal fun...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.11.049
更新日期：2021-02-15 00:00:00
abstract：BACKGROUND:Impulsivity (I) and anxiety (A) were hypothesized to be crucial clinical features in adolescents with at-risk behavior. We therefore classified them into sub-groups according to these two major dimensions. The study examined the relevance of these groups by describing their major diagnoses and behavioral cha...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00455-x
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Depressive disorders affect approximately 18.8 million patients annually. Influenza, a preventable infectious disease, leads to 50 million new cases each year and up to 40,000 deaths annually. It is believed that depressive symptoms somatize and can lead to decreased immune function. This hypothesis has litt...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2011.12.037
更新日期：2012-04-01 00:00:00
abstract：BACKGROUND:The successful use of serotonin reuptake inhibitors (SRIs) in obsessive-compulsive disorder (OCD) has led to the hypothesis that serotonin plays a pivotal role in the pathogenesis of OCD. The purpose of the present study was to investigate the role of the serotonin transporter (5-HTT) and serotonin 5-HT1B an...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.12.011
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Conflicting results in genetic studies of bipolar disorders may be due to the clinical and genetic heterogeneity of the disease. Age at onset of bipolar disorders may be a key indicator for identifying more homogeneous clinical subtypes. We tested whether early onset and late onset bipolar illness represent ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(99)00111-1
更新日期：2000-06-01 00:00:00
abstract：BACKGROUND:Recent studies have suggested that eating and sleep problems during early childhood may pose as risk factors for mood and anxiety disorders in later life. We aim to study the associations between early childhood sleep and eating problems, specifically high motor activity during sleep and irregularities in sl...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.05.025
更新日期：2006-11-01 00:00:00
abstract：OBJECTIVE:To assess the psychometric properties and the usefulness of the General Behavior Inventory (GBI) in the adolescent age range. METHOD:The GBI, the Schedule for Affective Disorders and Schizophrenia for School Age Children, Kiddie-SADS-Present and Lifetime Version (K-SADS-PL) and the Youth Self-Report (YSR) we...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(03)00115-0
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. METHODS:We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 34...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.08.017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:We aimed to examine differential effects of WMH on progression of depressive symptoms according to APOE ε4 status in the elderly. METHODS:We obtained data from elderly Korean subjects (n=707) aged 60 years or older at baseline from the CREDOS study from November 2005 to July 2014. A linear mixed model strat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.08.032
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Recent research has shown that a polymorphism in the dopamine D2 receptor gene (DRD2) moderates the association between stressful life events and depression. The present study builds off this literature and examines whether DRD2 moderates the effect of violent victimization on depression. Furthermore, the cu...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.03.027
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Late-life depression often remains undetected in primary care. However, as there is evidence that GPs do identify those with the most severe and persistent disorders, it is important to know more about the prognosis of depressive disorders that are not detected by GPs. METHODS:A one-year follow-up study of ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.06.006
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND:We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites. METHOD:In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affectiv...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00011-3
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Social anxiety disorder is fairly prevalent among alcohol abusing/dependent subjects. The objective of the present study was to investigate: (a) the incidence of social anxiety symptoms in inpatient alcoholics, (b) the effect of alcohol detoxification on these symptoms, and (c) whether a combined psychothera...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0165-0327(02)00094-0
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Little is known about depression in older people in sub-Saharan Africa, the associated impact of HIV, and the influence on health perceptions. OBJECTIVES:Examine the prevalence and correlates of depression; explore the relationship between depression and health perceptions in HIV-infected and -affected olde...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.005
更新日期：2013-10-01 00:00:00
abstract：BACKGROUND:Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cor...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.11.046
更新日期：2012-04-01 00:00:00
abstract：:Recent advances in our understanding of both short- and long-term therapeutic interventions for depressive disorders have necessitated greater precision in defining appropriate therapeutic interventions. While these remarkable changes in treatment have been based on the introduction of newer antidepressant agents, the...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(00)00357-8
更新日期：2001-01-01 00:00:00
abstract：:The paper reviews briefly and comments in detail on selected events in the history of lithium treatment. The events include Cade's discovery of lithium's antimanic action, the discovery and establishment of its prophylactic action, the ensuing debate, amelioration and prevention of side effects and risks, use during p...
journal_title：Journal of affective disorders
pub_type： 历史文章,杂志文章,评审
doi：10.1016/s0165-0327(01)00380-9
更新日期：2001-12-01 00:00:00
abstract：:The lifetime prevalence of mood disorders in women is approximately twice that of men. The underlying causality of this gender difference is not yet understood. There is increasing scientific attention to the modulation of the neuroendocrine system by fluctuating gonadal hormones. This review attempts to summarize our...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(02)00432-9
更新日期：2003-03-01 00:00:00
abstract：:Depression-related cognitive impairment (DRCI) is a condition which despite its initial treatment response, shows a progressive deterioration. No consistent therapeutic strategies have been proposed to combat this condition. This may be due to a reluctance to treat the cognitively impaired, a failure to recognise the ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/0165-0327(95)00070-4
更新日期：1996-01-22 00:00:00
abstract：OBJECTIVE:This research investigated the impact of adolescent onset bipolar illness on perceived family functioning in stabilized bipolar I (B) and unipolar (U) probands, and normal controls (C). METHOD:Sample N=119: 44 bipolar 1(17 M, 27 F), 30 unipolar (9 M, 21 F), and 45 controls (19 M, 26 F). Mean ages: 19.9, 18.5...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(00)00281-0
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Given the poor prognosis of late-life depression, it is crucial to identify those at risk. Our objective was to construct and validate a prediction rule for an unfavourable course of late-life depression. METHODS:For development and internal validation of the model, we used The Netherlands Study of Depressi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.04.026
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Somatic symptoms are an important adolescent health problem that affects individuals and the society as a whole. Although research focused on somatic symptoms has been very fruitful, studies about their longitudinal predictors are still in their early stages. The present study focuses on the relations betwee...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.03.071
更新日期：2020-06-15 00:00:00
abstract：:The authors compared the presentation and course of major depression in male geriatric inpatients with and without a diagnosis of dementia. Of 326 consecutive admissions to an inpatient geropsychiatry unit, 22 (7%) had a diagnosis of major depression without dementia, 35 (11%) had major depression with dementia. Both ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(97)01430-4
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:With the possible exception of cyclothymia in artists, there is a paucity of data in the literature on the temperament in different professions. METHODS:For this exploratory study, we sought to generate preliminary data on temperaments among psychiatric outpatients, including physicians (n=41), lawyers (n=3...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2004.08.003
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:Gene×environment (G×E) interactions are known to predict susceptibility to disorders such as depression and anxiety. Adverse experiences in childhood and number of stressful life events (SLEs) have been widely studied as environmental risk factors; however, SLE response has not yet been studied. Here we pres...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.09.043
更新日期：2012-02-01 00:00:00
abstract：:Oxcarbazepine, although structurally similar to carbamazepine, is metabolised very differently. As a consequence, oxcarbazepine's pharmacokinetic profile is comparatively less complex, and a more predictable, linear relationship between oxcarbazepine and blood levels is apparent. Furthermore, hepatic enzyme induction ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(02)00338-5
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions. METHODS:Extensive clinical interview and MINI were used to ascertain DSM-IV diagnoses of rapid cycling bipolar I (RCBPDI) or II (RCBPDII) ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.12.229
更新日期：2008-09-01 00:00:00
