Abstract:
BACKGROUND:Depression is associated with greater cardiac morbidity and mortality. One of the contributory factors for this may be altered cardiac autonomic activity in depression. However, cardiac autonomic involvement in depression remains controversial because of methodological issues. In this study, alteration of cardiac autonomic functions was studied in drug-naive patients with major depression without co-morbidity. Heart rate variability, a sensitive measure of neurocardiac autonomic regulation was used in addition to conventional methods of measuring cardiac autonomic functions. METHODS:We recruited 40 patients suffering from major depression, diagnosed based on DSM-IV-TR criteria. Their cardiac autonomic functions were measured using both conventional and heart rate variability measures. These were compared with those of age- and gender-matched healthy controls. RESULTS:Patients with major depression showed significantly lesser Valsalva ratio, maximum/minimum ratio and greater sympathovagal balance than healthy controls indicating decreased parasympathetic and increased sympathetic activity. CONCLUSIONS:Depression is associated with alteration of cardiac autonomic tone towards decreased parasympathetic activity and an increased sympathetic activity. It is possible that a common neurobiological dysfunction contributes to both depression and cardiac autonomic changes in the illness.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Udupa K,Sathyaprabha TN,Thirthalli J,Kishore KR,Lavekar GS,Raju TR,Gangadhar BNdoi
10.1016/j.jad.2006.10.007subject
Has Abstractpub_date
2007-06-01 00:00:00pages
137-41issue
1-3eissn
0165-0327issn
1573-2517pii
S0165-0327(06)00446-0journal_volume
100pub_type
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