Abstract：
BACKGROUND:We tested if duration and intensity of episodes in treatment-resistant affectively ill patients were related to cerebrospinal fluid (CSF) concentrations of monoamine metabolites. METHOD:In retrospective life charts were recorded every previous episode of 37 patients with severe treatment-refractory affective disorders. 'Accumulated burden of mood swings' (ABMS, sum of each episode length x episode depth) was used to estimate the accumulated illness burden. Homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) were analyzed in CSF of all patients and compared with 27 healthy controls. Data were analyzed using multiple regression analysis. RESULTS:CSF MHPG contributed strongly significant and positively to the ABMS. LIMITATIONS:The retrospective nature of the study. CONCLUSION:CSF concentrations of MHPG is positively related to ABMS over life. Thus, a specific involvement of norepinephrine in the long-term burden of affective illness is a likely reality.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Ehnvall A,Sjögren M,Zachrisson OC,Agren Hdoi
10.1016/s0165-0327(02)00011-3subject
Has Abstractpub_date
2003-04-01 00:00:00pages
185-9issue
2eissn
0165-0327issn
1573-2517pii
S0165032702000113journal_volume
74pub_type
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