Abstract：
:The antidepressant/antipanic drug phenelzine (PLZ) is both an inhibitor of, and a substrate for, monoamine oxidase (MAO). PLZ also causes an elevation of brain levels of the amino acid neurotransmitter gamma-aminobutyric acid (GABA); this action can be reversed by pretreatment with the MAO inhibitor tranylcypromine (TCP), suggesting that the GABA-elevating effect is largely the result of a metabolite of PLZ formed by MAO. In the present report, rats were pretreated with the nonselective MAO inhibitor TCP, the MAO-A inhibitor clorgyline and the MAO-B inhibitor (-)-deprenyl: at the doses used, clorgyline and (-)-deprenyl caused selective inhibition of MAO-A and MAO-B, respectively. Both TCP and (-)-deprenyl caused a greater reduction in the GABA-elevating action of PLZ than did clorgyline, suggesting that MAO-B is more important than MAO-A in the formation of the active metabolite of PLZ. The results also suggest that an effect other than, or in addition to, inhibition of GABA transaminase by the metabolite may be important in the GABA-elevating action.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Todd KG,Baker GBdoi
10.1016/0165-0327(95)00056-9subject
Has Abstractpub_date
1995-12-13 00:00:00pages
125-9issue
3eissn
0165-0327issn
1573-2517pii
0165032795000569journal_volume
35pub_type
杂志文章abstract：THEORETICAL BACKGROUND:In older people, anxiety disorders are among the most prevalent mental disorders and a high proportion suffers from clinically relevant anxiety symptoms. Despite studies suggesting an association of anxiety with health care utilization (HCU) and a resulting economic burden to the health care syst...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2018.02.011
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:While depression during pregnancy is one of the strongest risk factors for postnatal depression, it has been comparatively little studied, particularly in sub-Saharan Africa. METHODS:Cohort study nested within 4-weekly surveillance of all women of reproductive age to identify pregnancies and collect data on...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.04.009
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND:Altered reward and punishment function has been suggested as an important vulnerability factor for the development of Major Depressive Disorder (MDD). Prior ERP studies found evidence for neurophysiological dysfunctions in reinforcement processes in adults with MDD. To date, only few ERP studies have examine...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.01.017
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The Patient Health Questionnaire (PHQ-9) and Hospital Anxiety and Depression Scale (HADS) are commonly used measures in clinical practice and research. It is important that such scales measure the trait they purport to measure and that the impact of other measurement artefacts is minimal. Differential item f...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.11.015
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Genetic and physiological studies have implicated the striatum in bipolar disorder (BD). Although Glycogen synthase kinase 3 beta (GSK3β) has been suggested to play a role in the pathophysiology of BD since it is inhibited by lithium, it remains unknown how GSK3β activity might be involved. Therefore we exam...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.10.371
更新日期：2019-02-15 00:00:00
abstract：:Plasma and erythrocyte sodium (Na+), total and free (ultrafiltrable) plasma magnesium (Mg2+) as well as erythrocyte magnesium were measured in patients with affective disorders and in healthy control subjects. Depressed and manic patients had higher total plasma Mg2+ than did hospitalized healthy control subjects, but...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(83)90003-4
更新日期：1983-05-01 00:00:00
abstract：BACKGROUND:The monitoring of patients with an anxiety disorder can benefit from Routine Outcome Monitoring (ROM). As anxiety disorders differ in phenomenology, several anxiety questionnaires are included in ROM: Brief Scale for Anxiety (BSA), PADUA Inventory Revised (PI-R), Panic Appraisal Inventory (PAI), Penn State W...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.031
更新日期：2013-09-25 00:00:00
abstract：:Kraepelin had a modern vision of affective illness. He hypothesized that affective recurrences arose from enduring dispositions of depressive, cyclothymic, irritable, or 'manic' types. These dispositions appeared as 'temperaments' in English translations of his work. In the extreme, such temperamental gloominess or mo...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(00)00347-5
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Anxiety sensitivity (AS), or the fear of anxious arousal, is a transdiagnostic risk factor. Despite the proliferation of self-report research showing AS is related to anxiety, cognitive processes underlying AS are poorly understood. Specifically, AS may reflect processes related to early attentional orientat...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.11.067
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:The aim was to determine the risk of Mood Disorders (MD), particularly Bipolar Disorders (BD), in Multiple Sclerosis (MS) using standardized psychiatric diagnostic tools. METHODS:Case-control study. CASES:201 consecutive-patients with MS. CONTROLS:804 sex- and age-matched subjects without MS, randomly sel...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.11.008
更新日期：2014-02-01 00:00:00
abstract：:We explored the differential effect of some climatic factors such as temperature, atmospheric pressure, sunlight duration and humidity grade on the temporal distribution of violent and non-violent suicides, accidental and undetermined causes of death as well as homicides in Belgium, between 1969 and 1984. Our study in...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(92)90001-m
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:Greater diversity in the experience of negative and positive emotions - emodiversity - is associated with better mental health outcomes in the general population (Quoidbach et al. 2014). However, conceptual accounts of depression suggest this might differ in clinical depression. In this study, the diversity ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.04.060
更新日期：2020-08-01 00:00:00
abstract：:We examined the onsets of comorbid psychiatric disorders in patients with panic disorder (PD) (N = 54). In 42 patients (77.8%), PD was preceded by another psychiatric condition (secondary PD group), while in 12 patients (22.2%), PD occurred first or was the only diagnosed mental disorder (primary PD group). Patients w...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90080-4
更新日期：1993-02-01 00:00:00
abstract：BACKGROUND:Dextromethorphan is an over-the-counter antitussive agent that may be a rapidly acting treatment for bipolar depression. Like ketamine, it is an NMDA receptor antagonist. METHODS:We conducted a retrospective chart review of depressed patients with treatment resistant bipolar II or bipolar NOS disorder who w...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.05.050
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:The hopelessness theory of depression posits that individuals with negative cognitive styles are at risk of developing depression following negative life events. The purpose of this work was to examine whether individuals with cognitive vulnerability to depression (CVD) exhibit similar spontaneous brain acti...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.03.001
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Major depression is characterized by an impaired ability to evaluate and modify emotional responses as well as attention deficits, however the neural origins of these features are unresolved. The aim of the study was to investigate activation and functional connectivity changes during recognition and volunta...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.10.029
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:There is an increasing recognition of the relationship between mental illness and obesity in the pediatric population. Our objective was to explore the individual, biological and family determinants of depressive symptoms and HRQOL in youth with obesity in a clinical setting. METHODS:We studied 244 youth ag...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.09.014
更新日期：2015-02-01 00:00:00
abstract：BACKGROUND:Visits to emergency departments (EDs) for suicidal ideation or a suicide attempt have increased in the past decades. Yet comprehensive models of suicide are scarce, potentially enhancing misunderstandings from health professionals. This study aimed to investigate the applicability of the interpersonal-psycho...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.12.049
更新日期：2017-03-01 00:00:00
abstract：:This paper reviews evidence from both human and non-human primate studies concerning the role of early adverse experiences in the onset and course of adult depressive disorders. Despite accumulating evidence that stressful life events can play a major role in precipitating the onset of depressive episodes in humans, t...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(03)00046-6
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Depression is a frequent comorbidity of COPD and leads to worse clinical COPD-outcomes. PHQ-9 and PHQ-2 are two widely used brief instruments to assess depression. However, psychometric properties in COPD patients are unknown. This study examines factorial validity, measurement invariance and composite relia...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.02.037
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVES:It is of potentially great public health importance to determine whether youth-onset anxiety disorders are associated with the increased prevalence of subsequent bipolar I disorder (BD) among adults, and to identify risk factors for BD in this population. METHODS:The 2001-2002 National Epidemiologic Survey ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.01.029
更新日期：2007-11-01 00:00:00
abstract：BACKGROUND:The high comorbidity rate between bipolar disorder (BP) and anxiety disorder (AD) has been studied in depth. This comorbidity is not as high in Han Chinese in Taiwan. Therefore, we explored the genetic effects BP comorbid with AD. METHODS:We recruited 1316 participants: 286 with BP-I, 681 with BP-II, and 34...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.08.017
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:The introduction of an adult onset Separation Anxiety Disorder in the DSM-V recognises that separation anxiety can occur at any stage across the lifespan. In this paper, we examine whether adult separation anxiety, which is known to occur when people are apart from other people close to them, can also develo...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.03.147
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Studies have suggested that psychiatric comorbidities have major effects on antidepressant resistance in adult patients with major depressive disorder (MDD). However, the association between psychiatric comorbidities and antidepressant resistance remains unclear in adolescents with MDD. METHODS:A total of 1...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.038
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Childhood maltreatment is an established distal risk factor for later emotional problems, although research suggests this relationship is mediated by proximal factors. However, it is unclear if different forms of childhood maltreatment are related to unique emotion regulation strategies. In this study, we ex...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.11.028
更新日期：2015-03-15 00:00:00
abstract：BACKGROUND:Little is known about the early phases of bipolar disorders (BPAD) and most of current knowledge derives from putative "high-risk" studies conducted in populations of bipolar off-spring; such information may therefore be relevant only to a sub-group of at-risk subjects. METHODS:Retrospective assessment of t...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.12.021
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:Because of the relationship between childhood behavior disorders and adult substance abuse, we hypothesized that substance abusing adult bipolars were more likely to have had behavior disorders as children than nonabusing bipolar adults. METHODS:Conduct disorder (CD) symptoms in 132 bipolar adults were compa...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(97)00176-6
更新日期：1998-03-01 00:00:00
abstract：INTRODUCTION:Empirical evidence has suggested an association between mood and color sensitivity. The purpose of this study is to report on the psychometric properties of a new postpartum depression rating scale while at the same time showing a correlation between depression severity and impaired color sensitivity. MET...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.03.039
更新日期：2012-12-10 00:00:00
abstract：BACKGROUND:Cognitive compromise is a common experience for patients with depression and other mood disorders. Depressed patients sustain deficits in working memory and attentional distortions in emotional processing and negative attention biases, which may contribute to maintaining their depressive state. METHODS:The ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.08.080
更新日期：2018-01-01 00:00:00
abstract：:The advisability of continuing breastfeeding is an important issue for women with postpartum depression or psychosis. A review of the literature on psychotropic drugs in breast milk is presented. All of the major classes of psychotropic drugs (antidepressants, antipsychotics, antianxiety agents, lithium, hypnotics) ha...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/0165-0327(90)90092-m
更新日期：1990-07-01 00:00:00
