Abstract:
BACKGROUND:Many neuroimaging studies of patients with bipolar disorder have demonstrated functional hypofrontality (reduced activation of the frontal cortex), although this finding is still controversial. We previously found hypoactivation of the left prefrontal region in remitted subjects with bipolar disorder measured by one-channel near-infrared spectroscopy (NIRS). The aim of the present study was to clarify whether or not this finding was due to altered cerebral lateralization or caused by reduced cerebrovascular reactivity. METHODS:We enrolled nine remitted patients with bipolar disorder and nine normal controls. Hemodynamic responses in the prefrontal cortex during the verbal-fluency and hyperventilation tasks were monitored by 24-channel NIRS, which can measure oxygenated hemoglobin (OxyHb), deoxygenated hemoglobin, and total hemoglobin (TotalHb). RESULTS:The increases of OxyHb and TotalHb in the bipolar group were significantly smaller than that in the controls during the verbal-fluency task. The response of TotalHb during hyperventilation in the bipolar group was weaker than that in the controls. LIMITATIONS:The sample size was small. CONCLUSIONS:These findings suggest that the bilateral hypofrontality to a cognitive task is seen in remitted subjects with bipolar disorder, which may be related to vascular function as measured by the response to hyperventilation.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Matsuo K,Watanabe A,Onodera Y,Kato N,Kato Tdoi
10.1016/j.jad.2003.10.004subject
Has Abstractpub_date
2004-10-01 00:00:00pages
85-92issue
1eissn
0165-0327issn
1573-2517pii
S0165032703002659journal_volume
82pub_type
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