Abstract：
BACKGROUND:Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear. OBJECTIVES:This study aimed to assess the comparative efficacy and tolerability of racemic and esketamine for the treatment of unipolar and bipolar major depression. DESIGN:Systematic review and meta-analysis. DATA SOURCES:We searched PubMed, MEDLINE, Embase, PsycINFO, the Cochrane Central Register of Controlled Clinical Trials, and the Cochrane Database of Systematic Reviews for relevant studies published since database inception and December 17, 2019. STUDY ELIGIBILITY CRITERIA:We considered randomized controlled trials examining racemic or esketamine for the treatment of unipolar or bipolar major depression. OUTCOMES:Primary outcomes were response and remission from depression, change in depression severity, suicidality, retention in treatment, drop-outs, and drop-outs due to adverse events. ANALYSIS:Evidence from randomized controlled trials was synthesized as rate ratios (RRs) for treatment response, disorder remission, adverse events, and withdrawals and as standardized mean differences (SMDs) for change in symptoms, via random-effects meta-analyses. FINDINGS:24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater overall response (RR = 3.01 vs. RR = 1.38) and remission rates (RR = 3.70 vs. RR = 1.47), as well as lower dropouts (RR = 0.76 vs. RR = 1.37). CONCLUSIONS:Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Bahji A,Vazquez GH,Zarate CA Jrdoi
10.1016/j.jad.2020.09.071subject
Has Abstractpub_date
2021-01-01 00:00:00pages
542-555eissn
0165-0327issn
1573-2517pii
S0165-0327(20)32766-Xjournal_volume
278pub_type
杂志文章,评审abstract：BACKGROUND:Brain-derived neurotrophic factor (BDNF) has been hypothesized to be involved in the neurobiology of major depression. The aim of this study was to assess the possible relationships between depressive symptoms and serum and/or plasma BDNF levels during 1 year of antidepressant treatment. METHODS:Plasma and ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.05.005
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:In China, rural-to-urban migrant workers (MWs) are a large and vulnerable population that may be at high risk for depression, but previous studies focused on depressive symptoms of MWs and no study has investigated the epidemiology of major depressive disorder (MDD). The objective of this study was to determ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.04.031
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Marital status is one of the most frequently replicated predictors of suicide. The purpose of this study was to examine the effect of marital status on the risk of suicide by gender, using a large population-based cohort in Japan. METHODS:The Miyagi cohort study was a population-based, prospective cohort st...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2013.05.006
更新日期：2013-09-25 00:00:00
abstract：INTRODUCTION:The ubiquity and hazards posed by abnormal body composition and metabolic parameters in the bipolar population are a priority research and clinical issue. Herein, we summarize and synthesize international studies describing the rate of US National Cholesterol Education Program (NCEP) Expert Panel on Detect...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2010.04.012
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:Electroconvulsive therapy (ECT) is a highly effective treatment for depression but its use is limited by the risk of cognitive side effects. This study explored the potential of a novel approach, ultrabrief pulsewidth (0.3 ms) right unilateral (RUL-UB) ECT, to minimise cognitive effects while preserving effi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2007.06.012
更新日期：2007-11-01 00:00:00
abstract：:The pretreatment plasma ratio of tryptophan (Trp) to other large neutral amino acids (LNAA), thought to reflect brain serotonin formation, was determined in 44 inpatients with major depression, who were subsequently treated double-blind on a fixed-dose schedule for 4 weeks with the selective serotonin uptake inhibitor...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/0165-0327(90)90117-q
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Emerging evidence implicates the gut microbiota in central nervous system functioning via its effects on inflammation, the hypothalamic-pituitary axis, and/or neurotransmission. Our understanding of the cellular underpinnings of the brain-gut relationship is based almost exclusively on animal models with som...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.12.020
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Though the social functioning of most depressed outpatients improves with effective treatment, a subgroup may remain impaired after recovering from depression. The purpose of this study was to identify predictors of residual social impairment among patients who recovered from depression. METHODS:These data ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(98)00200-6
更新日期：1999-10-01 00:00:00
abstract：:The circannual results of the dexamethasone suppression test (DST) were compared in depressed and schizophrenic patients for the periods November-February and March-October. During the winter months, female depressive and schizophrenic patients had lower rates of DST nonsuppression as well as lower concentrations of p...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(92)90022-x
更新日期：1992-02-01 00:00:00
abstract：OBJECTIVE:Many studies report high prevalence rates for co-morbid alcohol problems in bipolar disorder (BP). Some hypothesize that individuals use alcohol to self-medicate, but few studies examine the range of possible reasons and none explicitly explores the role of mood state. We examined drinking motives in BP depre...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2011.09.005
更新日期：2012-02-01 00:00:00
abstract：BACKGROUND:Somatic symptoms are an important adolescent health problem that affects individuals and the society as a whole. Although research focused on somatic symptoms has been very fruitful, studies about their longitudinal predictors are still in their early stages. The present study focuses on the relations betwee...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.03.071
更新日期：2020-06-15 00:00:00
abstract：BACKGROUND:Higher depressive symptoms have been associated with lower future income. However, studies examining this issue have had limited follow-up times and have used self-reported measures of income. Also, possible confounders or mediators have not been accounted. METHODS:971 women and 738 men were selected from t...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.06.028
更新日期：2016-11-01 00:00:00
abstract：:The frequency of occurrence of prepubertal mania is contingent on how much adherence to episodic disorder with separate periods of mania and depression is required. While manic symptoms superimposed on other psychiatric disorders is not uncommon, non-comorbid bipolar disorder is rare. A number of developmental, phenom...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(98)00179-7
更新日期：1998-11-01 00:00:00
abstract：:The lifetime prevalence of mood disorders in women is approximately twice that of men. The underlying causality of this gender difference is not yet understood. There is increasing scientific attention to the modulation of the neuroendocrine system by fluctuating gonadal hormones. This review attempts to summarize our...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/s0165-0327(02)00432-9
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Depression is a seriously disabling public health problem with very high world-wide prevalence. This study examined cross-sectional association between depression and both inflammatory markers and laboratory data involved in metabolic disturbance among Japanese subjects. METHODS:This cross-sectional study i...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.09.014
更新日期：2019-01-15 00:00:00
abstract：OBJECTIVES:Disturbances in sleep and waking patterns are highly prevalent during mood episodes in bipolar disorder. The question remains whether these disturbances persist during phases of euthymia and whether they are heritable traits of bipolar disorder. The current study investigates objective sleep measures in a la...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2016.08.076
更新日期：2017-01-15 00:00:00
abstract：BACKGROUND:Two recent studies conducted in the US and in France found an unexpectedly high prevalence of a positive screen for bipolar disorder (BD) in primary care (PC). There are few studies of the prevalence of BD in PC and no information exists on the epidemiology of BD in Brazilian PC services. This study investig...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.05.040
更新日期：2012-12-20 00:00:00
abstract：BACKGROUND:The aim of this study was to characterize at the population level how innate features of temperament relate to experience of depressive mood and anxiety, and whether these symptoms have separable temperamental backgrounds. METHODS:The study subjects were 4773 members of the population-based Northern Finland...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2010.12.008
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND:Antidepressant treatment is associated with a high rate of poor response, and thus, biomarker development is warranted. METHODS:We aimed to synthesize studies investigating gene expression, small RNAs, and epigenomic biomarkers of antidepressant response. We conducted a narrative review of the literature. ...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2017.08.087
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Suicidal ideation is the most stable symptom of depression across episodes. This relative stability may be brought about by increased cognitive reactivity to sad mood (CR) during periods of remission. The idea is that a network of depressive cognitions, which include suicidal ideation, becomes strengthened w...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.06.013
更新日期：2010-04-01 00:00:00
abstract：:Thirty-eight patients with seasonal affective disorder (SAD) were compared with 33 non-seasonal recurrent major depressives (non-SAD) who presented during the winter months for differences in the prevalence of concurrent anxiety disorders and the impact of anxiety on treatment response. SAD patients received light the...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90076-v
更新日期：1993-05-01 00:00:00
abstract：BACKGROUND:Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear. METHODS:We assessed sleep disturbance rep...
journal_title：Journal of affective disorders
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jad.2019.10.033
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Comorbid personality disorders may predispose patients with mood disorders to suicide attempts (SAs), but factors mediating this effect are not well known. METHODS:Altogether 597 patients from three prospective cohort studies (Vantaa Depression Study, Jorvi Bipolar Study, and Vantaa Primary Care Depression ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.11.006
更新日期：2016-01-15 00:00:00
abstract：BACKGROUND:Perinatal distress is a significant public health problem that adversely impacts the individual and their family. The primary objective of this systematic review and meta-analysis was to identify factors that partners can modify to protect each other from developing perinatal depression and anxiety. METHOD:...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2015.02.023
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The aim of this naturalistic study was to compare the effectiveness of quetiapine and classical mood stabilizers, as mono- or combination therapy, in the long-term treatment of Bipolar Disorder (BD). METHODS:232 DSM-IV BD I (n=91) or BD II (n=141) patients, treated and followed up for four years, were studi...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2008.01.017
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Obesity, metabolic syndrome (MetS) and low adherence to Mediterranean diet are frequent in major depression patients and have been separately related with prognosis. The aim of this study is to analyse their predictive power on major depression outcome, at 6 and 12 months. METHODS:273 Major depressive patien...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.12.064
更新日期：2016-04-01 00:00:00
abstract：OBJECTIVE:To examine sex-specific time patterns of suicidal behaviour on railway tracks as basis of suicide preventive strategies. METHOD:Cases were derived from the National Central Registry of all person accidents on the German railway net (STABAG) between 1997 and 2002 satisfying the operational definition of suici...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2004.04.012
更新日期：2004-11-15 00:00:00
abstract：BACKGROUND:This review aimed to evaluate whether patients with panic disorder (PD) exhibit different heart rate variability (HRV) compared to healthy controls and to determine whether HRV is different in patients with PD after treatment. METHODS:Literature databases were searched for studies comparing resting-state HR...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/j.jad.2020.01.132
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND:Bipolar disorder (BD) broadly affects brain structure, in particular areas involved in emotion processing and cognition. In the last years, the psychiatric field's interest in machine learning approaches has been steadily growing, thanks to the potentiality of automatically discriminating patients from healt...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.06.019
更新日期：2019-09-01 00:00:00
abstract：BACKGROUND:Self-poisoning and self-injury have widely differing incidences in hospitals and in the community, which has led to confusion about the concept of self-harm. Categorising self-harm simply by a method may be clinically misleading because many hospital-attending patients switch from one method of harm to anoth...
journal_title：Journal of affective disorders
pub_type： 杂志文章,多中心研究
doi：10.1016/j.jad.2015.03.051
更新日期：2015-07-15 00:00:00
