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One year clinical and psychosocial outcomes of early-onset chronic depression.

Abstract：

BACKGROUND:Results from short-term treatment studies have demonstrated the efficacy of antidepressant medications for outpatients with early-onset chronic depression. However, scant data exists regarding the long-term outcome of these patients treated for this disorder. METHODS:The author conducted a one-year naturalistic follow-up study of 50 outpatients with early-onset, chronic depression, who were treated in a university-based psychopharmacology research clinic. Assessments were conducted blind to the patients' histories. RESULTS:Forty-eight percent of the total sample reported 9-12 months of sustained euthymia (Months Well). Among the patients who recovered, 50% relapsed. LIMITATIONS:The major limitations of this study were its small sample size and lack of a comparison group. CONCLUSIONS:These results data demonstrate that despite initial response, many outpatients with chronic depression seem to relapse after leaving university-based psychopharmacology centers.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Agosti V

doi

10.1016/s0165-0327(98)00040-8

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

171-5

issue

1-2

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(98)00040-8

journal_volume

54

pub_type

临床试验,杂志文章,随机对照试验

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