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Residual memory dysfunction in recurrent major depressive disorder--a longitudinal study from Juntendo University Mood Disorder Project.

Abstract：

BACKGROUND:Depression may increase the risk of developing Alzheimer's disease. Large cohort studies have shown that recurrent depression is associated with a risk of developing dementia. Other studies have documented smaller hippocampal volume in patients with recurrent depression. It is speculative that a greater risk of developing dementia may result from a higher number of previous depressive episodes. This study compared patients with recurrent and single-episode depression in the remitted stage, and healthy controls to elucidate the impact of the number of depressive episodes on memory. METHODS:Logical memory and visual reproduction subtests of the Wechsler Memory Scale-Revised were given to 68 patients with major depressive disorder (MDD) (30 patients with a single episode and residual 38 patients with recurrent multiple episodes) and 57 healthy controls. The patients with MDD received memory assessment at the time of initial remission and at the follow-up period 3 years after remission. RESULTS:At the time of initial remission, scores of both logical memory and visual reproduction subtests were significantly lower in both patient groups compared with healthy controls. At follow-up, memory dysfunction of the single-episode group disappeared, whereas scores in the recurrent group remained significantly lower than those of the single-episode group and controls. LIMITATIONS:All patients in the present study were on antidepressant medications. CONCLUSIONS:Patients with recurrent MDD with multiple depressive episodes showed residual memory dysfunction even after 3 years of remission. Persistence of memory deficits in the recurrent depression may be a risk factor for developing dementia.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Maeshima H,Baba H,Nakano Y,Satomura E,Namekawa Y,Takebayashi N,Suzuki T,Mimura M,Arai H

doi

10.1016/j.jad.2012.05.033

subject

Has Abstract

pub_date

2012-12-20 00:00:00

pages

84-8

issue

1-3

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(12)00387-4

journal_volume

143

pub_type

杂志文章

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Residual memory dysfunction in recurrent major depressive disorder--a longitudinal study from Juntendo University Mood Disorder Project.