The association of HTR2A polymorphisms with obsessive-compulsive disorder and its subtypes: A meta-analysis.

Abstract:

BACKGROUND:Genetic risk factors that contribute to obsessive-compulsive disorder (OCD) have yet to be elucidated. Historically, serotonergic dysfunction has been implicated. Evidence from the literature points towards the serotonin receptor 2A gene (HTR2A) as a primary candidate. Our meta-analysis investigated whether polymorphisms in HTR2A are associated with OCD or its subtypes, based on sex and age of onset. METHODS:Studies employing case-control or family-based designs were systematically searched, and those meeting eligibility underwent quality assessment, resulting in 18 studies. A random-effects meta-analysis using standard inverse-variance weighting to compute odds ratio (OR) was conducted. To examine sensitivity, results were also obtained using a more conservative statistical method. RESULTS:Three HTR2A variants were identified: T102C, G-1438A, and C516T. T102C and G-1438A were analyzed together due to strong linkage disequilibrium, where the 102T allele co-occurs with -1438A allele. Results reported as OR [95%CI] showed that the T/A allele were significantly associated with OCD, 1.14 [1.01, 1.29]. After stratification, results remained significant for females, 1.20 [1.00, 1.45], and early-onset OCD, 1.27 [1.02, 1.58], but not males, 1.06 [0.91, 1.23]. No associations were found for late-onset OCD, 0.98 [0.70, 1.37], or C516T, 1.22 [0.14, 10.37], but conclusions cannot be drawn from two studies. LIMITATIONS:Associations no longer reached significance with the conservative statistical approach. HTR2A alone cannot explain OCD complexity and limited samples reporting genetic data according to subtypes. CONCLUSIONS:These results suggest a possible association of HTR2A polymorphisms with OCD, but further investigations considering sex and age of onset with larger samples is needed.

journal_name

J Affect Disord

authors

Mattina GF,Samaan Z,Hall GB,Steiner M

doi

10.1016/j.jad.2020.06.016

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

278-289

eissn

0165-0327

issn

1573-2517

pii

S0165-0327(20)32374-0

journal_volume

275

pub_type

杂志文章,评审
  • The sick role, illness cognitions and outcomes in bipolar disorder.

    abstract:OBJECTIVE:In some individuals, recovery from episodes of mental illness may be impeded by maladaptive illness beliefs and behaviors. For individuals with chronic illness, acceptance of its presence and consequences is necessary to seek appropriate treatment, adjust their lifestyle, and adhere to recommended management ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.07.003

    authors: Berk M,Berk L,Dodd S,Fitzgerald PB,de Castella AR,Filia S,Filia K,Brnabic AJ,Kelin K,Montgomery W,Kulkarni J,Stafford L

    更新日期:2013-03-20 00:00:00

  • Reduced integrity of the uncinate fasciculus and cingulum in depression: A stem-by-stem analysis.

    abstract:INTRODUCTION:The subgenual cingulate gyrus (Brodmann's Area 25: BA25) is hypermetabolic in depression and has been targeted successfully with deep brain stimulation. Two of the white matter tracts that play a role in treatment response are the uncinate fasciculus (UF) and the cingulum bundle. The UF has three prefronta...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2018.04.055

    authors: Bhatia KD,Henderson LA,Hsu E,Yim M

    更新日期:2018-08-01 00:00:00

  • Investigating the potential role of BDNF and PRL genotypes on antidepressant response in depression patients: A prospective inception cohort study in treatment-free patients.

    abstract:BACKGROUND:Brain-derived neurotrophic factor (BDNF) is associated with response to antidepressant drugs in mood and anxiety disorders. Prolactin (PRL) is a pituitary hormone with behavioural effects, acting as a neurotrophic factor within the brain and may be involved in antidepressant response. OBJECTIVES:To investig...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.08.058

    authors: Ochi T,Vyalova NM,Losenkov IS,Levchuk LA,Osmanova DZ,Mikhalitskaya EV,Loonen AJM,Bosker FJ,Simutkin GG,Bokhan NA,Wilffert B,Ivanova SA

    更新日期:2019-12-01 00:00:00

  • Women with polycystic ovary syndrome associated with increased anxiety risk: A population-based cohort study in Taiwan.

    abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) has been associated with developing mental disorders in Western populations, but this association is poorly studied in Asians. Hence, using insurance claims data, this study evaluated the anxiety risk in women with PCOS. METHODS:Using Taiwan's National Health Insurance Resea...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.04.032

    authors: Harnod T,Tsai IJ,Wang JH,Lin SZ,Ding DD

    更新日期:2020-08-01 00:00:00

  • Antenatal depression: Prevalence and risk factor patterns across the gestational period.

    abstract:BACKGROUND:The prevalence of antenatal depression (AD) among pregnant women varies according to the populations under study and the periods of evaluation. This paper investigated patterns of AD prevalence and risk factors in a Brazilian sample. METHODS:Using semi-structured interviews as well as the Edinburgh Postnata...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2015.12.017

    authors: Castro e Couto T,Cardoso MN,Brancaglion MY,Faria GC,Garcia FD,Nicolato R,de Miranda DM,Corrêa H

    更新日期:2016-03-01 00:00:00

  • Spouse concordance for depressive disorders in a community sample.

    abstract::This article describes an analysis of spouse concordance for major depression and for other depressive experiences. Respondents to a community survey of married men and women (N = 586 couples) completed a modified version of the Diagnostic Interview Schedule from which diagnoses of major depression and dysthymia were ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(93)90096-3

    authors: McLeod JD

    更新日期:1993-01-01 00:00:00

  • Determinants of (non-)recognition of depression by general practitioners: results of the Netherlands Study of Depression and Anxiety.

    abstract:BACKGROUND:Although most depressed patients are treated in primary care, not all are recognized as such. This study explores the determinants of (non-)recognition of depression by general practitioners (GPs), with a focus on specific depression symptoms as possible determinants. METHODS:Recognition of depression by GP...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.01.006

    authors: Piek E,Nolen WA,van der Meer K,Joling KJ,Kollen BJ,Penninx BW,van Marwijk HW,van Hout HP

    更新日期:2012-05-01 00:00:00

  • Is sleep disturbance linked to short- and long-term outcomes following treatments for recurrent depression?

    abstract:BACKGROUND:Pre-treatment sleep disturbance has been shown to predict antidepressant treatment outcomes. How changes in sleep disturbance during acute treatment affect longitudinal outcomes, or whether continuation-phase treatment further improves sleep disturbance, is unclear. METHODS:We assessed sleep disturbance rep...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2019.10.033

    authors: Boland EM,Vittengl JR,Clark LA,Thase ME,Jarrett RB

    更新日期:2020-02-01 00:00:00

  • Clinical symptoms and platelet monoamine oxidase in subgroups and different states of affective disorders.

    abstract::Platelet monoamine oxidase activity (MAO) and clinical symptoms were examined in 116 individuals, 32 acute depressed patients and 84 healthy controls. The enzyme activity was lower in depressed women than controls. MAO activity correlated positively with rated clinical state in depressed women but not in depressed men...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/0165-0327(95)00043-m

    authors: Wahlund B,Sääf J,Wetterberg L

    更新日期:1995-10-09 00:00:00

  • Effects of vitamin D supplementation on depression and some involved neurotransmitters.

    abstract:BACKGROUND:Low vitamin D levels are associated with a dysregulated hypothalamic-pituitary-adrenal (HPA) axis and depression but a causal relationship has not been established. This study aimed to evaluate the effects of vitamin D supplementation on depression severity, serum 25(OH)D, and some neurotransmitters in patie...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.03.029

    authors: Kaviani M,Nikooyeh B,Zand H,Yaghmaei P,Neyestani TR

    更新日期:2020-05-15 00:00:00

  • Attempted suicide short intervention program influences coping among patients with a history of attempted suicide.

    abstract:BACKGROUND:The development of individual coping strategies for suicidal crises is essential for suicide prevention. However, the influence of a brief intervention and the effect on coping strategies is largely unknown. This study aimed to investigate the influence of the Attempted Suicide Short Intervention Program on ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.11.059

    authors: Gysin-Maillart A,Soravia L,Schwab S

    更新日期:2020-03-01 00:00:00

  • Psychological well-being and dual-use of cigarettes and e-cigarettes among high school students in Canada.

    abstract:BACKGROUND:Cigarette and e-cigarette use are prevalent among Canadian adolescents. Evidence shows psychiatric comorbidity with adolescent cigarette smoking, but little is known about psychological well-being among dual users of e-cigarettes and cigarettes. This study examined the association between dual-use status and...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.01.085

    authors: Shan L,Manzione LC,Azagba S

    更新日期:2020-03-15 00:00:00

  • The utility of NIRS technology for exploring emotional processing in children.

    abstract:BACKGROUND:Deficits in emotional processing and, in particular, in emotional self-regulation represent non-specific risk factors for transdiagnostic poor outcomes. Researches have been focusing on the investigation of possible emotional processing and regulation biomarkers. The present brief review of the literature ai...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,评审

    doi:10.1016/j.jad.2020.06.004

    authors: Mauri M,Crippa A,Bacchetta A,Grazioli S,Rosi E,Gazzola E,Gallace A,Nobile M

    更新日期:2020-09-01 00:00:00

  • A personality-based latent class typology of outpatients with major depressive disorder: association with symptomatology, prescription pattern and social function.

    abstract:BACKGROUND:While major depressive disorder (MDD) is considered to be a heterogeneous disorder, the nature of the heterogeneity remains unclear. Studies have attempted to classify patients with MDD using latent variable techniques, yet the empirical approaches to symptom-based subtyping of MDD have not provided conclusi...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2017.03.053

    authors: Hori H,Teraishi T,Nagashima A,Koga N,Ota M,Hattori K,Kim Y,Higuchi T,Kunugi H

    更新日期:2017-08-01 00:00:00

  • Treatment and prevention of depression after surgery for hip fracture in older people: cost-effectiveness analysis.

    abstract:OBJECTIVE:For older people who have had hip fracture surgery, to evaluate the cost-effectiveness of a nurse-led intervention in treating depression compared to treatment as usual (TAU), and to evaluate the cost-effectiveness of a psychological treatment for the prevention of depression. DESIGN:Two linked cost-effectiv...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2010.07.026

    authors: Romeo R,Knapp M,Banerjee S,Morris J,Baldwin R,Tarrier N,Pendleton N,Horan M,Burns A

    更新日期:2011-02-01 00:00:00

  • Depression with and without a history of psychotic symptoms in the general population: sociodemographic and clinical characteristics.

    abstract:BACKGROUND:The aim of this study was to find the sociodemographic and clinical characteristics of major depressive episode (MDE) with (MDE-HPS+) and without a history of psychotic symptoms (MDE-HPS) in the general population. METHODS:The Mental Health in the General Population survey interviewed 38,694 individuals in ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2020.04.048

    authors: Benard V,Pignon B,Geoffroy PA,Benradia I,Roelandt JL,Rolland B,Fovet T,D'Hondt F,Thomas P,Vaiva G,Amad A

    更新日期:2020-08-01 00:00:00

  • High frequency heart-rate variability predicts adolescent depressive symptoms, particularly anhedonia, across one year.

    abstract:BACKGROUND:Few prospective studies examine the link between lower heart rate variability (HRV) and depression symptoms in adolescents. A recent animal model specifically links HRV to anhedonia, suggesting a potential translational model for human research. METHOD:We investigated the association between spectral measur...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2016.02.040

    authors: Vazquez L,Blood JD,Wu J,Chaplin TM,Hommer RE,Rutherford HJ,Potenza MN,Mayes LC,Crowley MJ

    更新日期:2016-05-15 00:00:00

  • One year clinical and psychosocial outcomes of early-onset chronic depression.

    abstract:BACKGROUND:Results from short-term treatment studies have demonstrated the efficacy of antidepressant medications for outpatients with early-onset chronic depression. However, scant data exists regarding the long-term outcome of these patients treated for this disorder. METHODS:The author conducted a one-year naturali...

    journal_title:Journal of affective disorders

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0165-0327(98)00040-8

    authors: Agosti V

    更新日期:1999-07-01 00:00:00

  • A trajectory-based approach to understand the factors associated with persistent depressive symptoms in primary care.

    abstract:BACKGROUND:Depression screening in primary care yields high numbers. Knowledge of how depressive symptoms change over time is limited, making decisions about type, intensity, frequency and length of treatment and follow-up difficult. This study is aimed to identify depressive symptom trajectories and associated socio-d...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2012.12.021

    authors: Gunn J,Elliott P,Densley K,Middleton A,Ambresin G,Dowrick C,Herrman H,Hegarty K,Gilchrist G,Griffiths F

    更新日期:2013-06-01 00:00:00

  • Cluster randomised controlled trial of the e-couch Anxiety and Worry program in schools.

    abstract:BACKGROUND:Anxiety is a common mental health problem in youth. The current study aimed to test the effectiveness of an online self-directed anxiety prevention program in a school-based sample and to compare two methods of implementing an anxiety program in schools. METHODS:A three-arm cluster stratified randomised con...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.jad.2016.02.049

    authors: Calear AL,Batterham PJ,Poyser CT,Mackinnon AJ,Griffiths KM,Christensen H

    更新日期:2016-05-15 00:00:00

  • Reliability and validity of the Hospital Anxiety and Depression Scale and the Beck Depression Inventory (Full and FastScreen scales) in detecting depression in persons with hepatitis C.

    abstract:BACKGROUND:We examined the performance the Beck Depression Inventory (BDI) and its short form (BDI-FS) and the Hospital Anxiety and Depression Scale depression (HADS-D) and anxiety (HADS-A) subscales in detecting depression in a group of patients with hepatitis C. METHODS:SCID-CV was used to establish DSM-IV diagnosis...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2006.10.020

    authors: Golden J,Conroy RM,O'Dwyer AM

    更新日期:2007-06-01 00:00:00

  • Bulimia nervosa in atypical depression: the mediating role of cyclothymic temperament.

    abstract:OBJECTIVE:Recent data indicate significant clinical, biological, and treatment response overlap between eating and bipolar disorders, especially when soft symptoms of either spectrum disorders are considered. The aim of the present analyses is to evaluate the lifetime prevalence of bulimia nervosa (BN) in patients with...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2005.12.038

    authors: Perugi G,Toni C,Passino MC,Akiskal KK,Kaprinis S,Akiskal HS

    更新日期:2006-05-01 00:00:00

  • The direction of the relationship between symptoms of insomnia and psychiatric disorders in adolescents.

    abstract:BACKGROUND:This study assessed the direction of the relationship between symptoms of insomnia disorder, depression, various anxiety disorders and obsessive compulsive disorder (OCD) in adolescents after controlling for age, gender, chronotype, and outcome variable at baseline. METHODS:Data was collected in eight high ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2016.08.032

    authors: Alvaro PK,Roberts RM,Harris JK,Bruni O

    更新日期:2017-01-01 00:00:00

  • Cross-national difference in the prevalence of depression caused by the diagnostic threshold.

    abstract:BACKGROUND:According to published reports, the prevalence rates of major depressive disorder (MDD) in East-Asian countries are lower than in the West, but the reasons for this difference have not been fully investigated. METHODS:This study compared the Korean Epidemiologic Catchment Area study (KECAS) sample with the ...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2007.07.023

    authors: Chang SM,Hahm BJ,Lee JY,Shin MS,Jeon HJ,Hong JP,Lee HB,Lee DW,Cho MJ

    更新日期:2008-02-01 00:00:00

  • Single-nucleotide polymorphism in the human TIA1 gene interacts with stressful life events to predict the development of pathological anxiety symptoms in a Swedish population.

    abstract:BACKGROUND:The TIA1 gene encodes a prion-related RNA-binding protein that regulates stress-dependent synaptic plasticity and fear memory in mice. It is unknown whether genetic variation in human TIA1 is associated with differences in stress- and fear-related behavior in people. METHODS:A longitudinal, population-based...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2019.09.018

    authors: Rayman JB,Melas PA,Schalling M,Forsell Y,Kandel ER,Lavebratt C

    更新日期:2020-01-01 00:00:00

  • Prediction of treatment response in major depression: integration of concepts.

    abstract:BACKGROUND:Two promising approaches have been introduced for the prediction of treatment response in major depression: one concept is based on the activity in the rostral anterior cingulate cortex (rACC). Subjects with higher metabolic rates respond better to sleep deprivation or antidepressive medication. Another appr...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2006.07.021

    authors: Mulert C,Juckel G,Brunnmeier M,Karch S,Leicht G,Mergl R,Möller HJ,Hegerl U,Pogarell O

    更新日期:2007-03-01 00:00:00

  • Micro-scale environment and mental health in later life: Results from the Cognitive Function and Ageing Study II (CFAS II).

    abstract:BACKGROUND:Poor micro-scale environmental features, such as graffiti and broken windows, have been associated with crime and signs of social disorder with a potential impact on mental health. The aim of this study is to investigate the association between micro-scale environment and mental health problems in later life...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2017.05.001

    authors: Wu YT,Prina AM,Jones A,Barnes LE,Matthews FE,Brayne C,MRC CFAS.

    更新日期:2017-08-15 00:00:00

  • Relationship of anhedonia and anxiety to social rank, defeat and entrapment.

    abstract::There is good evidence to suggest that depression is highly correlated with perceptions of low rank and subordinate status (i.e. feeling inferior, low-self esteem, feeling that others look down on the self, and submissive behaviour). However, it is possible for people to feel inferior and anxious, and behave submissiv...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/s0165-0327(01)00392-5

    authors: Gilbert P,Allan S,Brough S,Melley S,Miles JN

    更新日期:2002-09-01 00:00:00

  • High prevalence of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: a preliminary study of 44 outpatients.

    abstract:BACKGROUND:Psychiatric comorbidity of autism spectrum disorder (ASD) has not been well examined. METHODS:Mood disorders in 44 consecutive outpatients with high-functioning ASD were examined at a university hospital according to DSM-IV. Inclusion criteria were an IQ of 70 or higher on the Wechsler Intelligence Scale an...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章

    doi:10.1016/j.jad.2008.02.015

    authors: Munesue T,Ono Y,Mutoh K,Shimoda K,Nakatani H,Kikuchi M

    更新日期:2008-12-01 00:00:00

  • Posttraumatic stress disorder, depression, and health-related quality of life in patients with bipolar disorder: review and new data from a multi-site community clinic sample.

    abstract:BACKGROUND:Evidence suggests that patients with bipolar disorder have an elevated risk for comorbid posttraumatic stress disorder (PTSD) compared to those without a bipolar diagnosis. Although bipolar disorder is associated with decreased health-related quality of life (HRQOL), it is unclear whether comorbid PTSD inter...

    journal_title:Journal of affective disorders

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1016/j.jad.2012.08.005

    authors: Bajor LA,Lai Z,Goodrich DE,Miller CJ,Penfold RB,Myra Kim H,Bauer MS,Kilbourne AM

    更新日期:2013-02-20 00:00:00