Abstract：
:In an attempt to elucidate the chemical pathology of mania one has to consider the pharmacology of the two most effective treatments for this illness: lithium and the neuroleptics. Some of the possible mechanisms of action of these drugs on catecholamine and indoleamine mechanisms are discussed. The majority of this article is based on my and my colleagues' work which has been carried out in this MRC Laboratory on the effect of lithium on biological variates in bipolar patients and the effects of the administration of antidepressant treatments in these patients. It is concluded that lithium has a similar action on these mechanisms in both unipolar and bipolar patients which might suggest a common pathology in both unipolar and bipolar illness. It is suggested that in order to maintain an euthymic state in a bipolar patient one should maintain a certain degree of sensitivity of 5-HT2 receptors. This sensitivity may be related to the activity of calcium channels and to the polyphosphoinositide system. The former system can be regulated by the administration of calcium channel antagonists which have been shown to be effective in the treatment of mania. The polyphosphoinositide system is one that can be regulated by therapeutic concentrations of lithium. It is concluded that co-administration of a calcium channel antagonist and lithium may be a very effective treatment for mania.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Wood Kdoi
10.1016/0165-0327(85)90019-9subject
Has Abstractpub_date
1985-05-01 00:00:00pages
215-23issue
3eissn
0165-0327issn
1573-2517pii
0165-0327(85)90019-9journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Regular physical activity reduces the risk of depression onset and is an effective treatment for mood disorders. Recent studies have reported that sedentary behavior (SB) increases the risk of depression in adults, but relationships of different types of SBs with depression have not been examined systematica...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.08.020
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Studies investigating how suicide attempting refugees and non-refugee migrants differ from Swedish-born individuals in terms of re-attempts and suicide are missing. It remains unknown how mental disorders and labour market marginalization (LMM) impact on these associations. METHODS:This longitudinal cohort ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.01.013
更新日期：2020-03-15 00:00:00
abstract：BACKGROUND:The population of older prisoners (age ≥50), a group with high suicide rates, is growing. We sought to explore the associations among functional disability, depression, and suicidal ideation (SI) among older prisoners, focusing on the mediating role of depression. METHODS:Study participants were 220 sentenc...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.01.156
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Research in paternal prenatal and postpartum depression has nearly doubled since prevalence rates were last meta-estimated in October 2009. An updated meta-analysis allows additional questions to be answered about moderators that influence risk. METHODS:Studies reporting paternal depression between the firs...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2016.07.044
更新日期：2016-12-01 00:00:00
abstract：:This study used a matched clinician and self-rating scale, the Inventory for Depressive Symptomatology (IDS; Rush et al., 1986), in the assessment of 48 patients meeting DSM-III-R criteria for non-psychotic major depressive disorder. Patients generally rated their symptoms as more severe than the clinician, but differ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(94)90101-5
更新日期：1994-08-01 00:00:00
abstract：INTRODUCTION:Recent studies suggest that Predominant Polarity (PP) may be an important specifier of Bipolar Disorder (BD), establishing distinct groups of patients and providing a potential tool for tailored treatment. PP has been associated to various clinical variables present in the course of the disorder, including...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.07.086
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Postnatal depression affects a significant number of parents; however, its co-occurrence in mothers and fathers has not been studied extensively. Identifying predictors and correlates of postnatal depressive symptoms can help develop effective interventions. METHODS:Questionnaires on several socio-demograph...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.10.033
更新日期：2016-01-15 00:00:00
abstract：BACKGROUND:Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant treatment for depression. Many patients with depression have comorbid anxiety symptoms. However, previous rTMS studies have focused on patients with depression, and often excluded comorbid anxiety. This real-world study aimed to inv...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.05.151
更新日期：2020-11-01 00:00:00
abstract：BACKGROUND:Sleep disturbance in bipolar disorder (BD) is common and is associated with a risk for mood episode recurrence. Thus, it is important to identify factors that are related to sleep disturbance in BD. This cross-sectional study investigated the association between exposure to light at night (LAN) and sleep par...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.07.031
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Abnormalities in the glucose metabolism cause nervous and organic damage and are a cardiovascular risk factor. They could be a main cause for the increased morbidity and mortality rates found in patients with bipolar disorders. The exact prevalence of diabetes and pre-diabetic abnormalities, however, is not ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.09.041
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:We examined seasonality and winter seasonal affective disorder (SAD) in the Old Order Amish of Lancaster County, Pennsylvania, a unique population that prohibits use of network electric light in their homes. METHODS:We estimated SAD using the seasonal pattern assessment questionnaire (SPAQ) in 130...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2012.10.019
更新日期：2013-05-01 00:00:00
abstract：BACKGROUND:Asylum seekers show high prevalence of depressive disorders compared to native populations. For the assessment of depression, the Patient Health Questionnaire-9 (PHQ-9) is a widely used instrument that has shown high validity and reliability. However, it is largely unknown whether PHQ-9 scores are comparable...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2019.11.055
更新日期：2020-02-01 00:00:00
abstract：OBJECTIVE:To examine the efficacy and tolerability of aripiprazole treatment for acute bipolar depression. METHODS:A six-week prospective, nonrandomized, open label study was conducted in depressed bipolar outpatients (types I, II, and NOS), as diagnosed by DSM-IV criteria. Previous treatments were continued unchanged...
journal_title：Journal of affective disorders
pub_type： 临床试验,杂志文章
doi：10.1016/j.jad.2008.01.004
更新日期：2008-09-01 00:00:00
abstract：:This article reports on the treatment received by 38 adolescents during an episode of major depression which had a median duration of 4 months. The one subject who received any pharmacologic treatment was prescribed an antianxiety agent. Sixteen percent received psychotherapy. These results are consistent with evidenc...
journal_title：Journal of affective disorders
pub_type： 杂志文章,评审
doi：10.1016/0165-0327(91)90037-s
更新日期：1991-03-01 00:00:00
abstract：BACKGROUND:Anger attacks, characterized by sudden episodes of intense anger with autonomic arousal, have been described in patients with major depressive disorder (MDD). This study compared the prevalence and clinical significance of anger attacks in unipolar versus bipolar depression. METHODS:Using the questionnaire ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/S0165-0327(02)00451-2
更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:The possibility of using biological measures to predict the trajectory of symptoms among adolescent psychiatric inpatients has important implications. This study aimed to examine emotion regulation ability (measured via self-report) and a hypothesized proxy in resting-state functional connectivity [RSFC] bet...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2017.08.064
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Patients with bipolar disorder, even euthymic, could suffer an impairment in their quality of life compared to healthy controls. Since no previous systematic review and meta-analysis has been conducted, the aim of the current study is to conduct a systematic review and meta-analysis of cross-sectional case-c...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析
doi：10.1016/j.jad.2019.05.032
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Lithium has been found to be effective in reducing suicide rates during long term treatment of patients with bipolar disorders. Data on the efficacy of anticonvulsant mood stabilizers in reducing suicide risk are sparse. METHOD:Charts of 140 bipolar patients treated continuously for a minimum of 6 months du...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00302-6
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:Service presentation may offer an opportunity for intervention prior to suicide. The study aimed to examine the characteristics, disorders and service use profiles of those who had died by suicide in Northern Ireland (NI) from 2005 to 2011. METHODS:An analysis of a database of deaths by suicide and undeterm...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.07.028
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:Cloninger's psychobiological model of personality has been extensively applied to subjects affected by mood disorders (MOOD). However, most studies are widely heterogeneous in terms of sample size, methods of assessment, and selection of participants. METHODS:We conducted a systematic review of literature a...
journal_title：Journal of affective disorders
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.jad.2015.12.077
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Various factors have been reported to be associated with the development of postpartum mood disorders. The relationship between postpartum mood disorders and putatively hormone-related phenomena such as premenstrual dysphoric disorder (PMDD) is unclear. This study attempts to determine whether such mood phen...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2005.04.007
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Depression is characterized by gender-specific distinctions, with women being affected more often than men. The Patient Health Questionnaire-9 (PHQ-9) is frequently used to assess depression in primary healthcare. Previous research has yielded heterogeneous findings on the factor structure, and little is kno...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2014.08.053
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:According to cognitive vulnerability stress models of depression, negative cognitions are supposed to be stable characteristics of depressed individuals even between depressive episodes. Depressed people also interpret social information more negatively than healthy people, perhaps even between depressive ep...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.02.017
更新日期：2006-07-01 00:00:00
abstract：:Rates of depression are compared by sex in epidemiologic surveys conducted in the United States, Canada, Germany and New Zealand. These surveys used similar sampling and diagnostic techniques and the data were standardized to the age and sex distribution of the USA to facilitate comparisons. Data show that the rates o...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/0165-0327(93)90025-f
更新日期：1993-10-01 00:00:00
abstract：BACKGROUND:Glycogen synthease kinase-3B is a key gene encoding a protein kinase which is abundant in brain, and is involved in signal transduction cascades of neuronal cell development and energy metabolism. Previous researches proposed GSK3B as a potential region for schizophrenia. METHOD:To validate the susceptibili...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2015.06.040
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Deficits in social cognition, e.g. theory of mind (ToM) represent core characteristics involved in the etiology of psychopathological symptoms and an important predictor of social competence. In bipolar affective disorder, evidence for ToM deficits is scant, although brain imaging studies and impairments in ...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2009.08.017
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:We assessed the prevalence of mood disturbance among women with prospectively documented polycystic ovary syndrome (PCOS). METHODS:Thirty-two women with PCOS completed the Center for Epidemiological Studies-Depression Rating Scale (CES-D). Clinical and biochemical characteristics were assessed. RESULTS:Six...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/s0165-0327(02)00117-9
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:It has been proposed that the broad major depressive disorder (MDD) construct is heterogenous. Koukopoulos has provided diagnostic criteria for an important subtype within that construct, "mixed depression" (MxD), which encompasses clinical pictures characterized by marked psychomotor or inner excitation and...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2018.01.025
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Relatively few studies test the interpersonal psychological theory's monotonicity hypothesis. The monotonicity hypothesis proposes that suicide capability (i.e., fearlessness about death and pain tolerance) is stable or increases linearly with exposure to painful and provocative events. Research is conflicte...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2020.12.169
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:Clinical studies suggest that olfactory sensitivity is reduced in major depression. Nevertheless, only little is known about the relationship between depressive symptoms and olfactory functions in healthy subjects. METHODS:The present study investigated the association between depressive symptoms and olfact...
journal_title：Journal of affective disorders
pub_type： 杂志文章
doi：10.1016/j.jad.2006.12.012
更新日期：2007-09-01 00:00:00
